Summary | |
---|---|
Symbol | TDG |
Name | thymine DNA glycosylase |
Aliases | G/T mismatch-specific thymine DNA glycosylase; hTDG; thymine-DNA glycosylase |
Chromosomal Location | 12q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF03167 Uracil DNA glycosylase superfamily |
Function |
DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine. Cannot remove 5-hydroxymethylcytosine (5hmC). According to an alternative model, involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil (5hmU) produced by deamination of 5hmC. Also involved in DNA repair by acting as a thymine-DNA glycosylase that mediates correction of G/T mispairs to G/C pairs: in the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. Its role in the repair of canonical base damage is however minor compared to its role in DNA demethylation. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine. |
Biological Process |
GO:0006220 pyrimidine nucleotide metabolic process GO:0006244 pyrimidine nucleotide catabolic process GO:0006284 base-excision repair GO:0006285 base-excision repair, AP site formation GO:0006298 mismatch repair GO:0006304 DNA modification GO:0009166 nucleotide catabolic process GO:0009219 pyrimidine deoxyribonucleotide metabolic process GO:0009223 pyrimidine deoxyribonucleotide catabolic process GO:0009262 deoxyribonucleotide metabolic process GO:0009264 deoxyribonucleotide catabolic process GO:0009394 2'-deoxyribonucleotide metabolic process GO:0016925 protein sumoylation GO:0018205 peptidyl-lysine modification GO:0019439 aromatic compound catabolic process GO:0019692 deoxyribose phosphate metabolic process GO:0032091 negative regulation of protein binding GO:0034655 nucleobase-containing compound catabolic process GO:0035510 DNA dealkylation GO:0035511 oxidative DNA demethylation GO:0035561 regulation of chromatin binding GO:0035562 negative regulation of chromatin binding GO:0040029 regulation of gene expression, epigenetic GO:0043393 regulation of protein binding GO:0044270 cellular nitrogen compound catabolic process GO:0044728 DNA methylation or demethylation GO:0045008 depyrimidination GO:0046386 deoxyribose phosphate catabolic process GO:0046434 organophosphate catabolic process GO:0046700 heterocycle catabolic process GO:0051098 regulation of binding GO:0051100 negative regulation of binding GO:0070988 demethylation GO:0070989 oxidative demethylation GO:0072527 pyrimidine-containing compound metabolic process GO:0072529 pyrimidine-containing compound catabolic process GO:0080111 DNA demethylation GO:1901136 carbohydrate derivative catabolic process GO:1901292 nucleoside phosphate catabolic process GO:1901361 organic cyclic compound catabolic process GO:1901565 organonitrogen compound catabolic process |
Molecular Function |
GO:0000700 mismatch base pair DNA N-glycosylase activity GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding GO:0001104 RNA polymerase II transcription cofactor activity GO:0003684 damaged DNA binding GO:0004844 uracil DNA N-glycosylase activity GO:0005080 protein kinase C binding GO:0008134 transcription factor binding GO:0008263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity GO:0016798 hydrolase activity, acting on glycosyl bonds GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds GO:0019104 DNA N-glycosylase activity GO:0030983 mismatched DNA binding GO:0032182 ubiquitin-like protein binding GO:0032183 SUMO binding GO:0043566 structure-specific DNA binding GO:0097506 deaminated base DNA N-glycosylase activity |
Cellular Component |
GO:0016604 nuclear body GO:0016605 PML body |
KEGG |
hsa03410 Base excision repair |
Reactome |
R-HSA-73884: Base Excision Repair R-HSA-73929: Base-Excision Repair, AP Site Formation R-HSA-110329: Cleavage of the damaged pyrimidine R-HSA-73894: DNA Repair R-HSA-73928: Depyrimidination R-HSA-110357: Displacement of DNA glycosylase by APEX1 R-HSA-212165: Epigenetic regulation of gene expression R-HSA-74160: Gene Expression R-HSA-392499: Metabolism of proteins R-HSA-597592: Post-translational protein modification R-HSA-110328: Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-73933: Resolution of Abasic Sites (AP sites) R-HSA-3108232: SUMO E3 ligases SUMOylate target proteins R-HSA-2990846: SUMOylation R-HSA-3108214: SUMOylation of DNA damage response and repair proteins R-HSA-5221030: TET1,2,3 and TDG demethylate DNA |
Summary | |
---|---|
Symbol | TDG |
Name | thymine DNA glycosylase |
Aliases | G/T mismatch-specific thymine DNA glycosylase; hTDG; thymine-DNA glycosylase |
Chromosomal Location | 12q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TDG and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TDG |
Name | thymine DNA glycosylase |
Aliases | G/T mismatch-specific thymine DNA glycosylase; hTDG; thymine-DNA glycosylase |
Chromosomal Location | 12q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of TDG in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | TDG |
Name | thymine DNA glycosylase |
Aliases | G/T mismatch-specific thymine DNA glycosylase; hTDG; thymine-DNA glycosylase |
Chromosomal Location | 12q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TDG in various data sets.
|
Points in the above scatter plot represent the mutation difference of TDG in various data sets.
|
Summary | |
---|---|
Symbol | TDG |
Name | thymine DNA glycosylase |
Aliases | G/T mismatch-specific thymine DNA glycosylase; hTDG; thymine-DNA glycosylase |
Chromosomal Location | 12q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TDG. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TDG |
Name | thymine DNA glycosylase |
Aliases | G/T mismatch-specific thymine DNA glycosylase; hTDG; thymine-DNA glycosylase |
Chromosomal Location | 12q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TDG. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TDG. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | TDG |
Name | thymine DNA glycosylase |
Aliases | G/T mismatch-specific thymine DNA glycosylase; hTDG; thymine-DNA glycosylase |
Chromosomal Location | 12q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TDG. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TDG |
Name | thymine DNA glycosylase |
Aliases | G/T mismatch-specific thymine DNA glycosylase; hTDG; thymine-DNA glycosylase |
Chromosomal Location | 12q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TDG expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TDG |
Name | thymine DNA glycosylase |
Aliases | G/T mismatch-specific thymine DNA glycosylase; hTDG; thymine-DNA glycosylase |
Chromosomal Location | 12q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TDG and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |