Summary | |
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Symbol | TDGF1 |
Name | teratocarcinoma-derived growth factor 1 |
Aliases | Cripto-1; CRGF; cripto-1 growth factor; epidermal growth factor-like cripto protein CR1 |
Chromosomal Location | 3p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Lipid-anchor, GPI-anchor Secreted Note=Released from the cell membrane by GPI cleavage. |
Domain |
PF09443 Cripto_Frl-1_Cryptic (CFC) |
Function |
GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated TDGF1 acts as a Nodal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells (PubMed:27881714). Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm (PubMed:11909953). |
Biological Process |
GO:0000187 activation of MAPK activity GO:0000578 embryonic axis specification GO:0001525 angiogenesis GO:0001667 ameboidal-type cell migration GO:0001763 morphogenesis of a branching structure GO:0002040 sprouting angiogenesis GO:0002042 cell migration involved in sprouting angiogenesis GO:0003002 regionalization GO:0007350 blastoderm segmentation GO:0007351 tripartite regional subdivision GO:0007389 pattern specification process GO:0007507 heart development GO:0008595 anterior/posterior axis specification, embryo GO:0009798 axis specification GO:0009880 embryonic pattern specification GO:0009948 anterior/posterior axis specification GO:0009952 anterior/posterior pattern specification GO:0010594 regulation of endothelial cell migration GO:0010595 positive regulation of endothelial cell migration GO:0010631 epithelial cell migration GO:0010632 regulation of epithelial cell migration GO:0010634 positive regulation of epithelial cell migration GO:0018105 peptidyl-serine phosphorylation GO:0018108 peptidyl-tyrosine phosphorylation GO:0018209 peptidyl-serine modification GO:0018212 peptidyl-tyrosine modification GO:0019827 stem cell population maintenance GO:0030335 positive regulation of cell migration GO:0030879 mammary gland development GO:0032147 activation of protein kinase activity GO:0033674 positive regulation of kinase activity GO:0034341 response to interferon-gamma GO:0034612 response to tumor necrosis factor GO:0035019 somatic stem cell population maintenance GO:0035282 segmentation GO:0035728 response to hepatocyte growth factor GO:0035729 cellular response to hepatocyte growth factor stimulus GO:0040017 positive regulation of locomotion GO:0043405 regulation of MAP kinase activity GO:0043406 positive regulation of MAP kinase activity GO:0043410 positive regulation of MAPK cascade GO:0043534 blood vessel endothelial cell migration GO:0043542 endothelial cell migration GO:0044344 cellular response to fibroblast growth factor stimulus GO:0045860 positive regulation of protein kinase activity GO:0048514 blood vessel morphogenesis GO:0048732 gland development GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0051272 positive regulation of cellular component movement GO:0070741 response to interleukin-6 GO:0070849 response to epidermal growth factor GO:0071346 cellular response to interferon-gamma GO:0071354 cellular response to interleukin-6 GO:0071356 cellular response to tumor necrosis factor GO:0071364 cellular response to epidermal growth factor stimulus GO:0071774 response to fibroblast growth factor GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:0090130 tissue migration GO:0090132 epithelium migration GO:0098727 maintenance of cell number GO:2000147 positive regulation of cell motility |
Molecular Function |
GO:0008083 growth factor activity |
Cellular Component |
GO:0016324 apical plasma membrane GO:0019897 extrinsic component of plasma membrane GO:0019898 extrinsic component of membrane GO:0031225 anchored component of membrane GO:0045121 membrane raft GO:0045177 apical part of cell GO:0098589 membrane region GO:0098857 membrane microdomain |
KEGG | - |
Reactome |
R-HSA-1266738: Developmental Biology R-HSA-2892247: POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-1433617: Regulation of signaling by NODAL R-HSA-1181150: Signaling by NODAL R-HSA-452723: Transcriptional regulation of pluripotent stem cells |
Summary | |
---|---|
Symbol | TDGF1 |
Name | teratocarcinoma-derived growth factor 1 |
Aliases | Cripto-1; CRGF; cripto-1 growth factor; epidermal growth factor-like cripto protein CR1 |
Chromosomal Location | 3p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TDGF1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TDGF1 |
Name | teratocarcinoma-derived growth factor 1 |
Aliases | Cripto-1; CRGF; cripto-1 growth factor; epidermal growth factor-like cripto protein CR1 |
Chromosomal Location | 3p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TDGF1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | TDGF1 |
Name | teratocarcinoma-derived growth factor 1 |
Aliases | Cripto-1; CRGF; cripto-1 growth factor; epidermal growth factor-like cripto protein CR1 |
Chromosomal Location | 3p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TDGF1 in various data sets.
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Points in the above scatter plot represent the mutation difference of TDGF1 in various data sets.
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Summary | |
---|---|
Symbol | TDGF1 |
Name | teratocarcinoma-derived growth factor 1 |
Aliases | Cripto-1; CRGF; cripto-1 growth factor; epidermal growth factor-like cripto protein CR1 |
Chromosomal Location | 3p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TDGF1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TDGF1 |
Name | teratocarcinoma-derived growth factor 1 |
Aliases | Cripto-1; CRGF; cripto-1 growth factor; epidermal growth factor-like cripto protein CR1 |
Chromosomal Location | 3p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TDGF1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TDGF1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | TDGF1 |
Name | teratocarcinoma-derived growth factor 1 |
Aliases | Cripto-1; CRGF; cripto-1 growth factor; epidermal growth factor-like cripto protein CR1 |
Chromosomal Location | 3p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TDGF1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TDGF1 |
Name | teratocarcinoma-derived growth factor 1 |
Aliases | Cripto-1; CRGF; cripto-1 growth factor; epidermal growth factor-like cripto protein CR1 |
Chromosomal Location | 3p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TDGF1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TDGF1 |
Name | teratocarcinoma-derived growth factor 1 |
Aliases | Cripto-1; CRGF; cripto-1 growth factor; epidermal growth factor-like cripto protein CR1 |
Chromosomal Location | 3p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TDGF1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TDGF1 |
Name | teratocarcinoma-derived growth factor 1 |
Aliases | Cripto-1; CRGF; cripto-1 growth factor; epidermal growth factor-like cripto protein CR1 |
Chromosomal Location | 3p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TDGF1 collected from DrugBank database. |
There is no record. |