Summary | |
---|---|
Symbol | TDP1 |
Name | tyrosyl-DNA phosphodiesterase 1 |
Aliases | FLJ11090; tyr-DNA phosphodiesterase 1 |
Chromosomal Location | 14q32.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Cytoplasm |
Domain |
PF06087 Tyrosyl-DNA phosphodiesterase |
Function |
DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate. |
Biological Process |
GO:0000012 single strand break repair GO:0006302 double-strand break repair GO:0090305 nucleic acid phosphodiester bond hydrolysis |
Molecular Function |
GO:0003697 single-stranded DNA binding GO:0004518 nuclease activity GO:0004527 exonuclease activity GO:0008081 phosphoric diester hydrolase activity GO:0017005 3'-tyrosyl-DNA phosphodiesterase activity GO:0042578 phosphoric ester hydrolase activity GO:0070259 tyrosyl-DNA phosphodiesterase activity |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-5693532: DNA Double-Strand Break Repair R-HSA-73894: DNA Repair R-HSA-5693571: Nonhomologous End-Joining (NHEJ) |
Summary | |
---|---|
Symbol | TDP1 |
Name | tyrosyl-DNA phosphodiesterase 1 |
Aliases | FLJ11090; tyr-DNA phosphodiesterase 1 |
Chromosomal Location | 14q32.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TDP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TDP1 |
Name | tyrosyl-DNA phosphodiesterase 1 |
Aliases | FLJ11090; tyr-DNA phosphodiesterase 1 |
Chromosomal Location | 14q32.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TDP1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | TDP1 |
Name | tyrosyl-DNA phosphodiesterase 1 |
Aliases | FLJ11090; tyr-DNA phosphodiesterase 1 |
Chromosomal Location | 14q32.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TDP1 in various data sets.
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Points in the above scatter plot represent the mutation difference of TDP1 in various data sets.
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Summary | |
---|---|
Symbol | TDP1 |
Name | tyrosyl-DNA phosphodiesterase 1 |
Aliases | FLJ11090; tyr-DNA phosphodiesterase 1 |
Chromosomal Location | 14q32.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TDP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TDP1 |
Name | tyrosyl-DNA phosphodiesterase 1 |
Aliases | FLJ11090; tyr-DNA phosphodiesterase 1 |
Chromosomal Location | 14q32.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TDP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TDP1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | TDP1 |
Name | tyrosyl-DNA phosphodiesterase 1 |
Aliases | FLJ11090; tyr-DNA phosphodiesterase 1 |
Chromosomal Location | 14q32.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TDP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TDP1 |
Name | tyrosyl-DNA phosphodiesterase 1 |
Aliases | FLJ11090; tyr-DNA phosphodiesterase 1 |
Chromosomal Location | 14q32.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TDP1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TDP1 |
Name | tyrosyl-DNA phosphodiesterase 1 |
Aliases | FLJ11090; tyr-DNA phosphodiesterase 1 |
Chromosomal Location | 14q32.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TDP1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |