Browse TENM2

Summary
SymbolTENM2
Nameteneurin transmembrane protein 2
Aliases KIAA1127; Ten-M2; ODZ2; odz, odd Oz/ten-m homolog 2 (Drosophila); TNM2; neurestin alpha; odd Oz/ten-m homolo ......
Chromosomal Location5q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Single-pass membrane protein Endoplasmic reticulum Golgi apparatus Cell junction, synapse Cell projection, dendritic spine Cell projection, filopodium Cell projection, growth cone Cell junction, synapse, postsynaptic cell membrane Single-pass membrane protein Cell junction, synapse, synaptosome Note=Colocalizes with ADGRL1 across intercellular junctions. ; SUBCELLULAR LOCATION: Isoform 2: Cell membrane. Note=Colocalizes with ADGRL1 across intercellular junctions.; SUBCELLULAR LOCATION: Ten-2 intracellular domain: Nucleus, PML body
Domain PF06484 Teneurin Intracellular Region
PF15636 GHH signature containing HNH/Endo VII superfamily nuclease toxin
Function

Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion (By similarity). May function as a cellular signal transducer. ; FUNCTION: Isoform 2: Acts as a ligand of the ADGRL1 receptor. Mediates axon guidance and heterophilic cell-cell adhesion. ; FUNCTION: Ten-2 intracellular domain: Induces gene transcription inhibition.

> Gene Ontology
 
Biological Process GO:0030031 cell projection assembly
GO:0031346 positive regulation of cell projection organization
GO:0044089 positive regulation of cellular component biogenesis
GO:0046847 filopodium assembly
GO:0051489 regulation of filopodium assembly
GO:0051491 positive regulation of filopodium assembly
GO:0060491 regulation of cell projection assembly
GO:0097264 self proteolysis
Molecular Function GO:0046982 protein heterodimerization activity
Cellular Component GO:0016604 nuclear body
GO:0016605 PML body
GO:0030175 filopodium
GO:0030425 dendrite
GO:0030426 growth cone
GO:0030427 site of polarized growth
GO:0043197 dendritic spine
GO:0044309 neuron spine
GO:0045211 postsynaptic membrane
GO:0097060 synaptic membrane
GO:0098794 postsynapse
GO:0098858 actin-based cell projection
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolTENM2
Nameteneurin transmembrane protein 2
Aliases KIAA1127; Ten-M2; ODZ2; odz, odd Oz/ten-m homolog 2 (Drosophila); TNM2; neurestin alpha; odd Oz/ten-m homolo ......
Chromosomal Location5q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between TENM2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolTENM2
Nameteneurin transmembrane protein 2
Aliases KIAA1127; Ten-M2; ODZ2; odz, odd Oz/ten-m homolog 2 (Drosophila); TNM2; neurestin alpha; odd Oz/ten-m homolo ......
Chromosomal Location5q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of TENM2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolTENM2
Nameteneurin transmembrane protein 2
Aliases KIAA1127; Ten-M2; ODZ2; odz, odd Oz/ten-m homolog 2 (Drosophila); TNM2; neurestin alpha; odd Oz/ten-m homolo ......
Chromosomal Location5q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of TENM2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.0350.917
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.530.383
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.4490.386
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1470.74
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.1410.934
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.5090.807
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-1.2510.149
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-1.2970.313
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-1.20.382
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.0060.989
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.2720.659
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-1.0490.00532
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of TENM2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141714.3014.30.196
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 414250250.222
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277322.212.39.90.224
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275922.215.36.90.542
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211728.617.6110.476
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86250250.473
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131130.827.33.51
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.112.5-1.41
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59022.2-22.20.505
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 382723.73.7200.037
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221318.2018.20.274
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161431.27.124.10.175
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 111307.7-7.71
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 51208.3-8.31
Summary
SymbolTENM2
Nameteneurin transmembrane protein 2
Aliases KIAA1127; Ten-M2; ODZ2; odz, odd Oz/ten-m homolog 2 (Drosophila); TNM2; neurestin alpha; odd Oz/ten-m homolo ......
Chromosomal Location5q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TENM2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolTENM2
Nameteneurin transmembrane protein 2
Aliases KIAA1127; Ten-M2; ODZ2; odz, odd Oz/ten-m homolog 2 (Drosophila); TNM2; neurestin alpha; odd Oz/ten-m homolo ......
Chromosomal Location5q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TENM2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TENM2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolTENM2
Nameteneurin transmembrane protein 2
Aliases KIAA1127; Ten-M2; ODZ2; odz, odd Oz/ten-m homolog 2 (Drosophila); TNM2; neurestin alpha; odd Oz/ten-m homolo ......
Chromosomal Location5q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TENM2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolTENM2
Nameteneurin transmembrane protein 2
Aliases KIAA1127; Ten-M2; ODZ2; odz, odd Oz/ten-m homolog 2 (Drosophila); TNM2; neurestin alpha; odd Oz/ten-m homolo ......
Chromosomal Location5q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of TENM2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolTENM2
Nameteneurin transmembrane protein 2
Aliases KIAA1127; Ten-M2; ODZ2; odz, odd Oz/ten-m homolog 2 (Drosophila); TNM2; neurestin alpha; odd Oz/ten-m homolo ......
Chromosomal Location5q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between TENM2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolTENM2
Nameteneurin transmembrane protein 2
Aliases KIAA1127; Ten-M2; ODZ2; odz, odd Oz/ten-m homolog 2 (Drosophila); TNM2; neurestin alpha; odd Oz/ten-m homolo ......
Chromosomal Location5q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting TENM2 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.