Summary | |
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Symbol | TENM2 |
Name | teneurin transmembrane protein 2 |
Aliases | KIAA1127; Ten-M2; ODZ2; odz, odd Oz/ten-m homolog 2 (Drosophila); TNM2; neurestin alpha; odd Oz/ten-m homolo ...... |
Chromosomal Location | 5q35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass membrane protein Endoplasmic reticulum Golgi apparatus Cell junction, synapse Cell projection, dendritic spine Cell projection, filopodium Cell projection, growth cone Cell junction, synapse, postsynaptic cell membrane Single-pass membrane protein Cell junction, synapse, synaptosome Note=Colocalizes with ADGRL1 across intercellular junctions. ; SUBCELLULAR LOCATION: Isoform 2: Cell membrane. Note=Colocalizes with ADGRL1 across intercellular junctions.; SUBCELLULAR LOCATION: Ten-2 intracellular domain: Nucleus, PML body |
Domain |
PF06484 Teneurin Intracellular Region PF15636 GHH signature containing HNH/Endo VII superfamily nuclease toxin |
Function |
Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion (By similarity). May function as a cellular signal transducer. ; FUNCTION: Isoform 2: Acts as a ligand of the ADGRL1 receptor. Mediates axon guidance and heterophilic cell-cell adhesion. ; FUNCTION: Ten-2 intracellular domain: Induces gene transcription inhibition. |
Biological Process |
GO:0030031 cell projection assembly GO:0031346 positive regulation of cell projection organization GO:0044089 positive regulation of cellular component biogenesis GO:0046847 filopodium assembly GO:0051489 regulation of filopodium assembly GO:0051491 positive regulation of filopodium assembly GO:0060491 regulation of cell projection assembly GO:0097264 self proteolysis |
Molecular Function |
GO:0046982 protein heterodimerization activity |
Cellular Component |
GO:0016604 nuclear body GO:0016605 PML body GO:0030175 filopodium GO:0030425 dendrite GO:0030426 growth cone GO:0030427 site of polarized growth GO:0043197 dendritic spine GO:0044309 neuron spine GO:0045211 postsynaptic membrane GO:0097060 synaptic membrane GO:0098794 postsynapse GO:0098858 actin-based cell projection |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | TENM2 |
Name | teneurin transmembrane protein 2 |
Aliases | KIAA1127; Ten-M2; ODZ2; odz, odd Oz/ten-m homolog 2 (Drosophila); TNM2; neurestin alpha; odd Oz/ten-m homolo ...... |
Chromosomal Location | 5q35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TENM2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TENM2 |
Name | teneurin transmembrane protein 2 |
Aliases | KIAA1127; Ten-M2; ODZ2; odz, odd Oz/ten-m homolog 2 (Drosophila); TNM2; neurestin alpha; odd Oz/ten-m homolo ...... |
Chromosomal Location | 5q35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TENM2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TENM2 |
Name | teneurin transmembrane protein 2 |
Aliases | KIAA1127; Ten-M2; ODZ2; odz, odd Oz/ten-m homolog 2 (Drosophila); TNM2; neurestin alpha; odd Oz/ten-m homolo ...... |
Chromosomal Location | 5q35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TENM2 in various data sets.
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Points in the above scatter plot represent the mutation difference of TENM2 in various data sets.
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Summary | |
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Symbol | TENM2 |
Name | teneurin transmembrane protein 2 |
Aliases | KIAA1127; Ten-M2; ODZ2; odz, odd Oz/ten-m homolog 2 (Drosophila); TNM2; neurestin alpha; odd Oz/ten-m homolo ...... |
Chromosomal Location | 5q35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TENM2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | TENM2 |
Name | teneurin transmembrane protein 2 |
Aliases | KIAA1127; Ten-M2; ODZ2; odz, odd Oz/ten-m homolog 2 (Drosophila); TNM2; neurestin alpha; odd Oz/ten-m homolo ...... |
Chromosomal Location | 5q35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TENM2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TENM2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TENM2 |
Name | teneurin transmembrane protein 2 |
Aliases | KIAA1127; Ten-M2; ODZ2; odz, odd Oz/ten-m homolog 2 (Drosophila); TNM2; neurestin alpha; odd Oz/ten-m homolo ...... |
Chromosomal Location | 5q35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TENM2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | TENM2 |
Name | teneurin transmembrane protein 2 |
Aliases | KIAA1127; Ten-M2; ODZ2; odz, odd Oz/ten-m homolog 2 (Drosophila); TNM2; neurestin alpha; odd Oz/ten-m homolo ...... |
Chromosomal Location | 5q35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TENM2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TENM2 |
Name | teneurin transmembrane protein 2 |
Aliases | KIAA1127; Ten-M2; ODZ2; odz, odd Oz/ten-m homolog 2 (Drosophila); TNM2; neurestin alpha; odd Oz/ten-m homolo ...... |
Chromosomal Location | 5q35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TENM2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TENM2 |
Name | teneurin transmembrane protein 2 |
Aliases | KIAA1127; Ten-M2; ODZ2; odz, odd Oz/ten-m homolog 2 (Drosophila); TNM2; neurestin alpha; odd Oz/ten-m homolo ...... |
Chromosomal Location | 5q35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TENM2 collected from DrugBank database. |
There is no record. |