Summary | |
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Symbol | TEX40 |
Name | testis expressed 40 |
Aliases | DKFZP566E164; C11orf20; chromosome 11 open reading frame 20; Testis-expressed sequence 40 protein |
Chromosomal Location | 11q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell projection, cilium, flagellum membrane Peripheral membrane protein Note=Specifically located in the principal piece of sperm tail (PubMed:28226241). Although it does not contain a transmembrane domain, localizes with the CatSper complex at the flagellum membrane (PubMed:28226241). |
Domain | - |
Function |
Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for a distribution of the CatSper complex in linear quadrilateral nanodomains along the flagellum, maximizing fertilization inside the mammalian female reproductive tract. |
Biological Process |
GO:0007126 meiotic nuclear division GO:0007140 male meiosis GO:0007283 spermatogenesis GO:0048232 male gamete generation GO:0051321 meiotic cell cycle GO:1903046 meiotic cell cycle process |
Molecular Function | - |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | TEX40 |
Name | testis expressed 40 |
Aliases | DKFZP566E164; C11orf20; chromosome 11 open reading frame 20; Testis-expressed sequence 40 protein |
Chromosomal Location | 11q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TEX40 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TEX40 |
Name | testis expressed 40 |
Aliases | DKFZP566E164; C11orf20; chromosome 11 open reading frame 20; Testis-expressed sequence 40 protein |
Chromosomal Location | 11q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TEX40 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | TEX40 |
Name | testis expressed 40 |
Aliases | DKFZP566E164; C11orf20; chromosome 11 open reading frame 20; Testis-expressed sequence 40 protein |
Chromosomal Location | 11q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TEX40 in various data sets.
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Points in the above scatter plot represent the mutation difference of TEX40 in various data sets.
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Summary | |
---|---|
Symbol | TEX40 |
Name | testis expressed 40 |
Aliases | DKFZP566E164; C11orf20; chromosome 11 open reading frame 20; Testis-expressed sequence 40 protein |
Chromosomal Location | 11q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TEX40. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TEX40 |
Name | testis expressed 40 |
Aliases | DKFZP566E164; C11orf20; chromosome 11 open reading frame 20; Testis-expressed sequence 40 protein |
Chromosomal Location | 11q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TEX40. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TEX40. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TEX40 |
Name | testis expressed 40 |
Aliases | DKFZP566E164; C11orf20; chromosome 11 open reading frame 20; Testis-expressed sequence 40 protein |
Chromosomal Location | 11q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TEX40. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TEX40 |
Name | testis expressed 40 |
Aliases | DKFZP566E164; C11orf20; chromosome 11 open reading frame 20; Testis-expressed sequence 40 protein |
Chromosomal Location | 11q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TEX40 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TEX40 |
Name | testis expressed 40 |
Aliases | DKFZP566E164; C11orf20; chromosome 11 open reading frame 20; Testis-expressed sequence 40 protein |
Chromosomal Location | 11q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TEX40 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TEX40 |
Name | testis expressed 40 |
Aliases | DKFZP566E164; C11orf20; chromosome 11 open reading frame 20; Testis-expressed sequence 40 protein |
Chromosomal Location | 11q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TEX40 collected from DrugBank database. |
There is no record. |