Browse TFAM

Summary
SymbolTFAM
Nametranscription factor A, mitochondrial
Aliases TCF6; TCF6L2; MTTFA; mitochondrial transcription factor 1; mitochondrial transcription factor A; transcripti ......
Chromosomal Location10q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Mitochondrion Mitochondrion matrix, mitochondrion nucleoid
Domain PF00505 HMG (high mobility group) box
PF09011 HMG-box domain
Function

Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation (PubMed:29445193). Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA.

> Gene Ontology
 
Biological Process GO:0000959 mitochondrial RNA metabolic process
GO:0006260 DNA replication
GO:0006261 DNA-dependent DNA replication
GO:0006352 DNA-templated transcription, initiation
GO:0006356 regulation of transcription from RNA polymerase I promoter
GO:0006360 transcription from RNA polymerase I promoter
GO:0006390 transcription from mitochondrial promoter
GO:0006391 transcription initiation from mitochondrial promoter
GO:0033108 mitochondrial respiratory chain complex assembly
Molecular Function GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001159 core promoter proximal region DNA binding
GO:0001221 transcription cofactor binding
GO:0001223 transcription coactivator binding
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003682 chromatin binding
GO:0008134 transcription factor binding
GO:0008301 DNA binding, bending
GO:0031072 heat shock protein binding
GO:0070363 mitochondrial light strand promoter sense binding
Cellular Component GO:0005759 mitochondrial matrix
GO:0009295 nucleoid
GO:0042645 mitochondrial nucleoid
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-74160: Gene Expression
R-HSA-1592230: Mitochondrial biogenesis
R-HSA-163282: Mitochondrial transcription initiation
R-HSA-1852241: Organelle biogenesis and maintenance
R-HSA-504046: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
R-HSA-75944: Transcription from mitochondrial promoters
R-HSA-2151201: Transcriptional activation of mitochondrial biogenesis
Summary
SymbolTFAM
Nametranscription factor A, mitochondrial
Aliases TCF6; TCF6L2; MTTFA; mitochondrial transcription factor 1; mitochondrial transcription factor A; transcripti ......
Chromosomal Location10q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between TFAM and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between TFAM and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
29872558Colon CarcinomaPromote immunityTFAM is a novel mediator of immunogenic cancer cell death. Importantly, the release of TFAM, a mitochondrial DAMP, by apoptotic cells may contribute to spautin-1-induced ICD via its action on the receptor AGER. This immunogenic effect of spautin-1-treated cancer cells was lost when TFAM or AGER were neutralized by specific antibodies.
Summary
SymbolTFAM
Nametranscription factor A, mitochondrial
Aliases TCF6; TCF6L2; MTTFA; mitochondrial transcription factor 1; mitochondrial transcription factor A; transcripti ......
Chromosomal Location10q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of TFAM in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolTFAM
Nametranscription factor A, mitochondrial
Aliases TCF6; TCF6L2; MTTFA; mitochondrial transcription factor 1; mitochondrial transcription factor A; transcripti ......
Chromosomal Location10q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of TFAM in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.3450.218
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.5710.706
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.1760.881
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1290.587
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.1020.943
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.1650.928
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0280.942
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.1640.921
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.1130.95
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.3430.777
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.0170.569
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0230.748
> Mutation difference between responders and non-responders
 

There is no record.

Summary
SymbolTFAM
Nametranscription factor A, mitochondrial
Aliases TCF6; TCF6L2; MTTFA; mitochondrial transcription factor 1; mitochondrial transcription factor A; transcripti ......
Chromosomal Location10q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TFAM. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolTFAM
Nametranscription factor A, mitochondrial
Aliases TCF6; TCF6L2; MTTFA; mitochondrial transcription factor 1; mitochondrial transcription factor A; transcripti ......
Chromosomal Location10q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TFAM. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TFAM.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolTFAM
Nametranscription factor A, mitochondrial
Aliases TCF6; TCF6L2; MTTFA; mitochondrial transcription factor 1; mitochondrial transcription factor A; transcripti ......
Chromosomal Location10q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TFAM. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolTFAM
Nametranscription factor A, mitochondrial
Aliases TCF6; TCF6L2; MTTFA; mitochondrial transcription factor 1; mitochondrial transcription factor A; transcripti ......
Chromosomal Location10q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of TFAM expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolTFAM
Nametranscription factor A, mitochondrial
Aliases TCF6; TCF6L2; MTTFA; mitochondrial transcription factor 1; mitochondrial transcription factor A; transcripti ......
Chromosomal Location10q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between TFAM and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolTFAM
Nametranscription factor A, mitochondrial
Aliases TCF6; TCF6L2; MTTFA; mitochondrial transcription factor 1; mitochondrial transcription factor A; transcripti ......
Chromosomal Location10q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting TFAM collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.