Summary | |
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Symbol | TFAM |
Name | transcription factor A, mitochondrial |
Aliases | TCF6; TCF6L2; MTTFA; mitochondrial transcription factor 1; mitochondrial transcription factor A; transcripti ...... |
Chromosomal Location | 10q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Mitochondrion Mitochondrion matrix, mitochondrion nucleoid |
Domain |
PF00505 HMG (high mobility group) box PF09011 HMG-box domain |
Function |
Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation (PubMed:29445193). Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA. |
Biological Process |
GO:0000959 mitochondrial RNA metabolic process GO:0006260 DNA replication GO:0006261 DNA-dependent DNA replication GO:0006352 DNA-templated transcription, initiation GO:0006356 regulation of transcription from RNA polymerase I promoter GO:0006360 transcription from RNA polymerase I promoter GO:0006390 transcription from mitochondrial promoter GO:0006391 transcription initiation from mitochondrial promoter GO:0033108 mitochondrial respiratory chain complex assembly |
Molecular Function |
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001159 core promoter proximal region DNA binding GO:0001221 transcription cofactor binding GO:0001223 transcription coactivator binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003682 chromatin binding GO:0008134 transcription factor binding GO:0008301 DNA binding, bending GO:0031072 heat shock protein binding GO:0070363 mitochondrial light strand promoter sense binding |
Cellular Component |
GO:0005759 mitochondrial matrix GO:0009295 nucleoid GO:0042645 mitochondrial nucleoid |
KEGG | - |
Reactome |
R-HSA-74160: Gene Expression R-HSA-1592230: Mitochondrial biogenesis R-HSA-163282: Mitochondrial transcription initiation R-HSA-1852241: Organelle biogenesis and maintenance R-HSA-504046: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription R-HSA-75944: Transcription from mitochondrial promoters R-HSA-2151201: Transcriptional activation of mitochondrial biogenesis |
Summary | |
---|---|
Symbol | TFAM |
Name | transcription factor A, mitochondrial |
Aliases | TCF6; TCF6L2; MTTFA; mitochondrial transcription factor 1; mitochondrial transcription factor A; transcripti ...... |
Chromosomal Location | 10q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TFAM and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between TFAM and anti-tumor immunity in human cancer.
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Summary | |
---|---|
Symbol | TFAM |
Name | transcription factor A, mitochondrial |
Aliases | TCF6; TCF6L2; MTTFA; mitochondrial transcription factor 1; mitochondrial transcription factor A; transcripti ...... |
Chromosomal Location | 10q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TFAM in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TFAM |
Name | transcription factor A, mitochondrial |
Aliases | TCF6; TCF6L2; MTTFA; mitochondrial transcription factor 1; mitochondrial transcription factor A; transcripti ...... |
Chromosomal Location | 10q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TFAM in various data sets.
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There is no record. |
Summary | |
---|---|
Symbol | TFAM |
Name | transcription factor A, mitochondrial |
Aliases | TCF6; TCF6L2; MTTFA; mitochondrial transcription factor 1; mitochondrial transcription factor A; transcripti ...... |
Chromosomal Location | 10q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TFAM. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TFAM |
Name | transcription factor A, mitochondrial |
Aliases | TCF6; TCF6L2; MTTFA; mitochondrial transcription factor 1; mitochondrial transcription factor A; transcripti ...... |
Chromosomal Location | 10q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TFAM. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TFAM. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TFAM |
Name | transcription factor A, mitochondrial |
Aliases | TCF6; TCF6L2; MTTFA; mitochondrial transcription factor 1; mitochondrial transcription factor A; transcripti ...... |
Chromosomal Location | 10q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TFAM. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TFAM |
Name | transcription factor A, mitochondrial |
Aliases | TCF6; TCF6L2; MTTFA; mitochondrial transcription factor 1; mitochondrial transcription factor A; transcripti ...... |
Chromosomal Location | 10q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TFAM expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TFAM |
Name | transcription factor A, mitochondrial |
Aliases | TCF6; TCF6L2; MTTFA; mitochondrial transcription factor 1; mitochondrial transcription factor A; transcripti ...... |
Chromosomal Location | 10q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TFAM and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TFAM |
Name | transcription factor A, mitochondrial |
Aliases | TCF6; TCF6L2; MTTFA; mitochondrial transcription factor 1; mitochondrial transcription factor A; transcripti ...... |
Chromosomal Location | 10q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TFAM collected from DrugBank database. |
There is no record. |