Summary | |
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Symbol | TFAP2A |
Name | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) |
Aliases | AP-2; TFAP2; AP2TF; transcription factor AP-2 alpha (activating enhancer-binding protein 2 alpha); AP-2alpha ...... |
Chromosomal Location | 6p24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF03299 Transcription factor AP-2 |
Function |
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. |
Biological Process |
GO:0001501 skeletal system development GO:0001503 ossification GO:0001654 eye development GO:0001655 urogenital system development GO:0001822 kidney development GO:0002072 optic cup morphogenesis involved in camera-type eye development GO:0003404 optic vesicle morphogenesis GO:0003407 neural retina development GO:0003409 optic cup structural organization GO:0007423 sensory organ development GO:0007605 sensory perception of sound GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0010039 response to iron ion GO:0010842 retina layer formation GO:0010944 negative regulation of transcription by competitive promoter binding GO:0016331 morphogenesis of embryonic epithelium GO:0021545 cranial nerve development GO:0021557 oculomotor nerve development GO:0021559 trigeminal nerve development GO:0021602 cranial nerve morphogenesis GO:0021603 cranial nerve formation GO:0021622 oculomotor nerve morphogenesis GO:0021623 oculomotor nerve formation GO:0021675 nerve development GO:0021783 preganglionic parasympathetic fiber development GO:0030278 regulation of ossification GO:0030282 bone mineralization GO:0030326 embryonic limb morphogenesis GO:0030500 regulation of bone mineralization GO:0030501 positive regulation of bone mineralization GO:0031076 embryonic camera-type eye development GO:0031214 biomineral tissue development GO:0034505 tooth mineralization GO:0035107 appendage morphogenesis GO:0035108 limb morphogenesis GO:0035113 embryonic appendage morphogenesis GO:0035115 embryonic forelimb morphogenesis GO:0035136 forelimb morphogenesis GO:0042471 ear morphogenesis GO:0042472 inner ear morphogenesis GO:0042476 odontogenesis GO:0042481 regulation of odontogenesis GO:0042482 positive regulation of odontogenesis GO:0043010 camera-type eye development GO:0043523 regulation of neuron apoptotic process GO:0043525 positive regulation of neuron apoptotic process GO:0043583 ear development GO:0045778 positive regulation of ossification GO:0048048 embryonic eye morphogenesis GO:0048483 autonomic nervous system development GO:0048486 parasympathetic nervous system development GO:0048532 anatomical structure arrangement GO:0048562 embryonic organ morphogenesis GO:0048568 embryonic organ development GO:0048592 eye morphogenesis GO:0048593 camera-type eye morphogenesis GO:0048596 embryonic camera-type eye morphogenesis GO:0048701 embryonic cranial skeleton morphogenesis GO:0048704 embryonic skeletal system morphogenesis GO:0048705 skeletal system morphogenesis GO:0048706 embryonic skeletal system development GO:0048736 appendage development GO:0048839 inner ear development GO:0050954 sensory perception of mechanical stimulus GO:0051402 neuron apoptotic process GO:0060021 palate development GO:0060041 retina development in camera-type eye GO:0060042 retina morphogenesis in camera-type eye GO:0060173 limb development GO:0060348 bone development GO:0060349 bone morphogenesis GO:0060900 embryonic camera-type eye formation GO:0061029 eyelid development in camera-type eye GO:0070167 regulation of biomineral tissue development GO:0070169 positive regulation of biomineral tissue development GO:0070170 regulation of tooth mineralization GO:0070172 positive regulation of tooth mineralization GO:0070997 neuron death GO:0071241 cellular response to inorganic substance GO:0071248 cellular response to metal ion GO:0071281 cellular response to iron ion GO:0072001 renal system development GO:0072593 reactive oxygen species metabolic process GO:0090596 sensory organ morphogenesis GO:1901214 regulation of neuron death GO:1901216 positive regulation of neuron death GO:1904888 cranial skeletal system development GO:1990267 response to transition metal nanoparticle GO:2000027 regulation of organ morphogenesis GO:2000377 regulation of reactive oxygen species metabolic process GO:2000378 negative regulation of reactive oxygen species metabolic process |
Molecular Function |
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001046 core promoter sequence-specific DNA binding GO:0001047 core promoter binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001159 core promoter proximal region DNA binding GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003682 chromatin binding GO:0003713 transcription coactivator activity |
Cellular Component |
GO:0005813 centrosome |
KEGG | - |
Reactome |
R-HSA-8866907: Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-392499: Metabolism of proteins R-HSA-8866904: Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-597592: Post-translational protein modification R-HSA-3108232: SUMO E3 ligases SUMOylate target proteins R-HSA-2990846: SUMOylation R-HSA-3232118: SUMOylation of transcription factors R-HSA-8866911: TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866910: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866906: TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8869496: TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8864260: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors |
Summary | |
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Symbol | TFAP2A |
Name | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) |
Aliases | AP-2; TFAP2; AP2TF; transcription factor AP-2 alpha (activating enhancer-binding protein 2 alpha); AP-2alpha ...... |
Chromosomal Location | 6p24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TFAP2A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TFAP2A |
Name | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) |
Aliases | AP-2; TFAP2; AP2TF; transcription factor AP-2 alpha (activating enhancer-binding protein 2 alpha); AP-2alpha ...... |
Chromosomal Location | 6p24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TFAP2A in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TFAP2A |
Name | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) |
Aliases | AP-2; TFAP2; AP2TF; transcription factor AP-2 alpha (activating enhancer-binding protein 2 alpha); AP-2alpha ...... |
Chromosomal Location | 6p24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TFAP2A in various data sets.
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Points in the above scatter plot represent the mutation difference of TFAP2A in various data sets.
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Summary | |
---|---|
Symbol | TFAP2A |
Name | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) |
Aliases | AP-2; TFAP2; AP2TF; transcription factor AP-2 alpha (activating enhancer-binding protein 2 alpha); AP-2alpha ...... |
Chromosomal Location | 6p24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TFAP2A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TFAP2A |
Name | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) |
Aliases | AP-2; TFAP2; AP2TF; transcription factor AP-2 alpha (activating enhancer-binding protein 2 alpha); AP-2alpha ...... |
Chromosomal Location | 6p24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TFAP2A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TFAP2A. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | TFAP2A |
Name | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) |
Aliases | AP-2; TFAP2; AP2TF; transcription factor AP-2 alpha (activating enhancer-binding protein 2 alpha); AP-2alpha ...... |
Chromosomal Location | 6p24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TFAP2A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TFAP2A |
Name | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) |
Aliases | AP-2; TFAP2; AP2TF; transcription factor AP-2 alpha (activating enhancer-binding protein 2 alpha); AP-2alpha ...... |
Chromosomal Location | 6p24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TFAP2A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TFAP2A |
Name | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) |
Aliases | AP-2; TFAP2; AP2TF; transcription factor AP-2 alpha (activating enhancer-binding protein 2 alpha); AP-2alpha ...... |
Chromosomal Location | 6p24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TFAP2A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TFAP2A |
Name | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) |
Aliases | AP-2; TFAP2; AP2TF; transcription factor AP-2 alpha (activating enhancer-binding protein 2 alpha); AP-2alpha ...... |
Chromosomal Location | 6p24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TFAP2A collected from DrugBank database. |
There is no record. |