Summary | |
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Symbol | TFPI2 |
Name | tissue factor pathway inhibitor 2 |
Aliases | TFPI-2; placental protein 5; retinal pigment epithelium cell factor 1 |
Chromosomal Location | 7q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted. |
Domain |
PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain |
Function |
May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin. |
Biological Process |
GO:0007596 blood coagulation GO:0007599 hemostasis GO:0010466 negative regulation of peptidase activity GO:0010951 negative regulation of endopeptidase activity GO:0034405 response to fluid shear stress GO:0045861 negative regulation of proteolysis GO:0050817 coagulation GO:0050878 regulation of body fluid levels GO:0051346 negative regulation of hydrolase activity GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0071498 cellular response to fluid shear stress |
Molecular Function |
GO:0004857 enzyme inhibitor activity GO:0004866 endopeptidase inhibitor activity GO:0004867 serine-type endopeptidase inhibitor activity GO:0005201 extracellular matrix structural constituent GO:0030414 peptidase inhibitor activity GO:0061134 peptidase regulator activity GO:0061135 endopeptidase regulator activity |
Cellular Component |
GO:0005578 proteinaceous extracellular matrix |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | TFPI2 |
Name | tissue factor pathway inhibitor 2 |
Aliases | TFPI-2; placental protein 5; retinal pigment epithelium cell factor 1 |
Chromosomal Location | 7q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TFPI2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TFPI2 |
Name | tissue factor pathway inhibitor 2 |
Aliases | TFPI-2; placental protein 5; retinal pigment epithelium cell factor 1 |
Chromosomal Location | 7q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TFPI2 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | TFPI2 |
Name | tissue factor pathway inhibitor 2 |
Aliases | TFPI-2; placental protein 5; retinal pigment epithelium cell factor 1 |
Chromosomal Location | 7q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TFPI2 in various data sets.
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Points in the above scatter plot represent the mutation difference of TFPI2 in various data sets.
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Summary | |
---|---|
Symbol | TFPI2 |
Name | tissue factor pathway inhibitor 2 |
Aliases | TFPI-2; placental protein 5; retinal pigment epithelium cell factor 1 |
Chromosomal Location | 7q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TFPI2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TFPI2 |
Name | tissue factor pathway inhibitor 2 |
Aliases | TFPI-2; placental protein 5; retinal pigment epithelium cell factor 1 |
Chromosomal Location | 7q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TFPI2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TFPI2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | TFPI2 |
Name | tissue factor pathway inhibitor 2 |
Aliases | TFPI-2; placental protein 5; retinal pigment epithelium cell factor 1 |
Chromosomal Location | 7q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TFPI2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TFPI2 |
Name | tissue factor pathway inhibitor 2 |
Aliases | TFPI-2; placental protein 5; retinal pigment epithelium cell factor 1 |
Chromosomal Location | 7q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TFPI2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TFPI2 |
Name | tissue factor pathway inhibitor 2 |
Aliases | TFPI-2; placental protein 5; retinal pigment epithelium cell factor 1 |
Chromosomal Location | 7q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TFPI2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |