Summary | |
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Symbol | TGFBR2 |
Name | transforming growth factor, beta receptor II (70/80kDa) |
Aliases | MFS2; transforming growth factor, beta receptor II (70-80kD); AAT3; FAA3; LDS1B; LDS2; LDS2B; RIIC; TAAD2; T ...... |
Chromosomal Location | 3p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type I membrane protein Membrane raft |
Domain |
PF08917 Transforming growth factor beta receptor 2 ectodomain PF07714 Protein tyrosine kinase |
Function |
Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. |
Biological Process |
GO:0001501 skeletal system development GO:0001525 angiogenesis GO:0001569 patterning of blood vessels GO:0001570 vasculogenesis GO:0001654 eye development GO:0001666 response to hypoxia GO:0001667 ameboidal-type cell migration GO:0001701 in utero embryonic development GO:0001763 morphogenesis of a branching structure GO:0001773 myeloid dendritic cell activation GO:0001837 epithelial to mesenchymal transition GO:0001865 NK T cell differentiation GO:0001947 heart looping GO:0002053 positive regulation of mesenchymal cell proliferation GO:0002062 chondrocyte differentiation GO:0002063 chondrocyte development GO:0002088 lens development in camera-type eye GO:0002274 myeloid leukocyte activation GO:0002507 tolerance induction GO:0002513 tolerance induction to self antigen GO:0002514 B cell tolerance induction GO:0002517 T cell tolerance induction GO:0002521 leukocyte differentiation GO:0002573 myeloid leukocyte differentiation GO:0002643 regulation of tolerance induction GO:0002645 positive regulation of tolerance induction GO:0002649 regulation of tolerance induction to self antigen GO:0002651 positive regulation of tolerance induction to self antigen GO:0002661 regulation of B cell tolerance induction GO:0002663 positive regulation of B cell tolerance induction GO:0002664 regulation of T cell tolerance induction GO:0002666 positive regulation of T cell tolerance induction GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0003007 heart morphogenesis GO:0003143 embryonic heart tube morphogenesis GO:0003148 outflow tract septum morphogenesis GO:0003149 membranous septum morphogenesis GO:0003151 outflow tract morphogenesis GO:0003170 heart valve development GO:0003171 atrioventricular valve development GO:0003175 tricuspid valve development GO:0003179 heart valve morphogenesis GO:0003181 atrioventricular valve morphogenesis GO:0003186 tricuspid valve morphogenesis GO:0003197 endocardial cushion development GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003203 endocardial cushion morphogenesis GO:0003205 cardiac chamber development GO:0003206 cardiac chamber morphogenesis GO:0003208 cardiac ventricle morphogenesis GO:0003214 cardiac left ventricle morphogenesis GO:0003231 cardiac ventricle development GO:0003272 endocardial cushion formation GO:0003274 endocardial cushion fusion GO:0003279 cardiac septum development GO:0003281 ventricular septum development GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis GO:0003415 chondrocyte hypertrophy GO:0003416 endochondral bone growth GO:0003417 growth plate cartilage development GO:0003418 growth plate cartilage chondrocyte differentiation GO:0003430 growth plate cartilage chondrocyte growth GO:0003431 growth plate cartilage chondrocyte development GO:0003433 chondrocyte development involved in endochondral bone morphogenesis GO:0006898 receptor-mediated endocytosis GO:0007159 leukocyte cell-cell adhesion GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007179 transforming growth factor beta receptor signaling pathway GO:0007182 common-partner SMAD protein phosphorylation GO:0007219 Notch signaling pathway GO:0007224 smoothened signaling pathway GO:0007368 determination of left/right symmetry GO:0007369 gastrulation GO:0007389 pattern specification process GO:0007423 sensory organ development GO:0007507 heart development GO:0007517 muscle organ development GO:0007565 female pregnancy GO:0007566 embryo implantation GO:0007568 aging GO:0007584 response to nutrient GO:0009612 response to mechanical stimulus GO:0009743 response to carbohydrate GO:0009746 response to hexose GO:0009749 response to glucose GO:0009799 specification of symmetry GO:0009855 determination of bilateral symmetry GO:0009991 response to extracellular stimulus GO:0010463 mesenchymal cell proliferation GO:0010464 regulation of mesenchymal cell proliferation GO:0010631 epithelial cell migration GO:0010632 regulation of epithelial cell migration GO:0010634 positive regulation of epithelial cell migration GO:0010717 regulation of epithelial to mesenchymal transition GO:0010718 positive regulation of epithelial to mesenchymal transition GO:0014706 striated muscle tissue development GO:0014855 striated muscle cell proliferation GO:0016049 cell growth GO:0016202 regulation of striated muscle tissue development GO:0017015 regulation of transforming growth factor beta receptor signaling pathway GO:0018105 peptidyl-serine phosphorylation GO:0018107 peptidyl-threonine phosphorylation GO:0018209 peptidyl-serine modification GO:0018210 peptidyl-threonine modification GO:0022407 regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0022612 gland morphogenesis GO:0030098 lymphocyte differentiation GO:0030099 myeloid cell differentiation GO:0030217 T cell differentiation GO:0030323 respiratory tube development GO:0030324 lung development GO:0030335 positive regulation of cell migration GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030879 mammary gland development GO:0031099 regeneration GO:0031100 animal organ regeneration GO:0031667 response to nutrient levels GO:0032147 activation of protein kinase activity GO:0033002 muscle cell proliferation GO:0033674 positive regulation of kinase activity GO:0034284 response to monosaccharide GO:0035050 embryonic heart tube development GO:0035162 embryonic hemopoiesis GO:0035239 tube morphogenesis GO:0035265 organ growth GO:0036293 response to decreased oxygen levels GO:0036314 response to sterol GO:0040017 positive regulation of locomotion GO:0042110 T cell activation GO:0042246 tissue regeneration GO:0042493 response to drug GO:0043010 camera-type eye development GO:0043011 myeloid dendritic cell differentiation GO:0043403 skeletal muscle tissue regeneration GO:0043415 positive regulation of skeletal muscle tissue regeneration GO:0043416 regulation of skeletal muscle tissue regeneration GO:0043627 response to estrogen GO:0044706 multi-multicellular organism process GO:0045580 regulation of T cell differentiation GO:0045582 positive regulation of T cell differentiation GO:0045619 regulation of lymphocyte differentiation GO:0045621 positive regulation of lymphocyte differentiation GO:0045765 regulation of angiogenesis GO:0045766 positive regulation of angiogenesis GO:0045785 positive regulation of cell adhesion GO:0045843 negative regulation of striated muscle tissue development GO:0045860 positive regulation of protein kinase activity GO:0045926 negative regulation of growth GO:0045927 positive regulation of growth GO:0046620 regulation of organ growth GO:0046621 negative regulation of organ growth GO:0046631 alpha-beta T cell activation GO:0046632 alpha-beta T cell differentiation GO:0046634 regulation of alpha-beta T cell activation GO:0046635 positive regulation of alpha-beta T cell activation GO:0046637 regulation of alpha-beta T cell differentiation GO:0046638 positive regulation of alpha-beta T cell differentiation GO:0048514 blood vessel morphogenesis GO:0048545 response to steroid hormone GO:0048562 embryonic organ morphogenesis GO:0048565 digestive tract development GO:0048568 embryonic organ development GO:0048588 developmental cell growth GO:0048634 regulation of muscle organ development GO:0048635 negative regulation of muscle organ development GO:0048638 regulation of developmental growth GO:0048639 positive regulation of developmental growth GO:0048640 negative regulation of developmental growth GO:0048645 animal organ formation GO:0048659 smooth muscle cell proliferation GO:0048660 regulation of smooth muscle cell proliferation GO:0048661 positive regulation of smooth muscle cell proliferation GO:0048701 embryonic cranial skeleton morphogenesis GO:0048704 embryonic skeletal system morphogenesis GO:0048705 skeletal system morphogenesis GO:0048706 embryonic skeletal system development GO:0048732 gland development GO:0048738 cardiac muscle tissue development GO:0048754 branching morphogenesis of an epithelial tube GO:0048762 mesenchymal cell differentiation GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050870 positive regulation of T cell activation GO:0051136 regulation of NK T cell differentiation GO:0051138 positive regulation of NK T cell differentiation GO:0051216 cartilage development GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051272 positive regulation of cellular component movement GO:0055017 cardiac muscle tissue growth GO:0055021 regulation of cardiac muscle tissue growth GO:0055022 negative regulation of cardiac muscle tissue growth GO:0055024 regulation of cardiac muscle tissue development GO:0055026 negative regulation of cardiac muscle tissue development GO:0055123 digestive system development GO:0060021 palate development GO:0060038 cardiac muscle cell proliferation GO:0060043 regulation of cardiac muscle cell proliferation GO:0060044 negative regulation of cardiac muscle cell proliferation GO:0060317 cardiac epithelial to mesenchymal transition GO:0060348 bone development GO:0060349 bone morphogenesis GO:0060350 endochondral bone morphogenesis GO:0060351 cartilage development involved in endochondral bone morphogenesis GO:0060389 pathway-restricted SMAD protein phosphorylation GO:0060411 cardiac septum morphogenesis GO:0060412 ventricular septum morphogenesis GO:0060419 heart growth GO:0060420 regulation of heart growth GO:0060425 lung morphogenesis GO:0060433 bronchus development GO:0060434 bronchus morphogenesis GO:0060438 trachea development GO:0060439 trachea morphogenesis GO:0060440 trachea formation GO:0060443 mammary gland morphogenesis GO:0060462 lung lobe development GO:0060463 lung lobe morphogenesis GO:0060485 mesenchyme development GO:0060537 muscle tissue development GO:0060541 respiratory system development GO:0060560 developmental growth involved in morphogenesis GO:0060562 epithelial tube morphogenesis GO:0061041 regulation of wound healing GO:0061117 negative regulation of heart growth GO:0061138 morphogenesis of a branching epithelium GO:0061343 cell adhesion involved in heart morphogenesis GO:0061371 determination of heart left/right asymmetry GO:0061448 connective tissue development GO:0070482 response to oxygen levels GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070723 response to cholesterol GO:0071559 response to transforming growth factor beta GO:0071560 cellular response to transforming growth factor beta stimulus GO:0071593 lymphocyte aggregation GO:0072132 mesenchyme morphogenesis GO:0072593 reactive oxygen species metabolic process GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0090130 tissue migration GO:0090132 epithelium migration GO:0090287 regulation of cellular response to growth factor stimulus GO:0090288 negative regulation of cellular response to growth factor stimulus GO:0090303 positive regulation of wound healing GO:0097028 dendritic cell differentiation GO:0097305 response to alcohol GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules GO:0098868 bone growth GO:1901342 regulation of vasculature development GO:1901861 regulation of muscle tissue development GO:1901862 negative regulation of muscle tissue development GO:1902105 regulation of leukocyte differentiation GO:1902107 positive regulation of leukocyte differentiation GO:1903034 regulation of response to wounding GO:1903036 positive regulation of response to wounding GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903706 regulation of hemopoiesis GO:1903708 positive regulation of hemopoiesis GO:1903844 regulation of cellular response to transforming growth factor beta stimulus GO:1903845 negative regulation of cellular response to transforming growth factor beta stimulus GO:1904018 positive regulation of vasculature development GO:1904019 epithelial cell apoptotic process GO:1904888 cranial skeletal system development GO:1905005 regulation of epithelial to mesenchymal transition involved in endocardial cushion formation GO:1905007 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation GO:1990086 lens fiber cell apoptotic process GO:2000027 regulation of organ morphogenesis GO:2000147 positive regulation of cell motility GO:2000377 regulation of reactive oxygen species metabolic process GO:2000379 positive regulation of reactive oxygen species metabolic process GO:2000826 regulation of heart morphogenesis |
Molecular Function |
GO:0004674 protein serine/threonine kinase activity GO:0004675 transmembrane receptor protein serine/threonine kinase activity GO:0004702 receptor signaling protein serine/threonine kinase activity GO:0005024 transforming growth factor beta-activated receptor activity GO:0005026 transforming growth factor beta receptor activity, type II GO:0005057 receptor signaling protein activity GO:0005126 cytokine receptor binding GO:0005160 transforming growth factor beta receptor binding GO:0005539 glycosaminoglycan binding GO:0019199 transmembrane receptor protein kinase activity GO:0019838 growth factor binding GO:0019955 cytokine binding GO:0031435 mitogen-activated protein kinase kinase kinase binding GO:0034713 type I transforming growth factor beta receptor binding GO:0046332 SMAD binding GO:0050431 transforming growth factor beta binding |
Cellular Component |
GO:0005901 caveola GO:0009897 external side of plasma membrane GO:0043235 receptor complex GO:0044853 plasma membrane raft GO:0045121 membrane raft GO:0061695 transferase complex, transferring phosphorus-containing groups GO:0070022 transforming growth factor beta receptor homodimeric complex GO:0098552 side of membrane GO:0098589 membrane region GO:0098802 plasma membrane receptor complex GO:0098857 membrane microdomain GO:1902554 serine/threonine protein kinase complex GO:1902911 protein kinase complex |
KEGG |
hsa04010 MAPK signaling pathway hsa04060 Cytokine-cytokine receptor interaction hsa04068 FoxO signaling pathway hsa04144 Endocytosis hsa04350 TGF-beta signaling pathway hsa04380 Osteoclast differentiation hsa04390 Hippo signaling pathway hsa04520 Adherens junction |
Reactome |
R-HSA-5688426: Deubiquitination R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-2173788: Downregulation of TGF-beta receptor signaling R-HSA-3304349: Loss of Function of SMAD2/3 in Cancer R-HSA-3656534: Loss of Function of TGFBR1 in Cancer R-HSA-3642278: Loss of Function of TGFBR2 in Cancer R-HSA-392499: Metabolism of proteins R-HSA-597592: Post-translational protein modification R-HSA-3315487: SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3304356: SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-162582: Signal Transduction R-HSA-170834: Signaling by TGF-beta Receptor Complex R-HSA-3304351: Signaling by TGF-beta Receptor Complex in Cancer R-HSA-2173789: TGF-beta receptor signaling activates SMADs R-HSA-2173791: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-3656532: TGFBR1 KD Mutants in Cancer R-HSA-3656535: TGFBR1 LBD Mutants in Cancer R-HSA-3645790: TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3642279: TGFBR2 MSI Frameshift Mutants in Cancer R-HSA-5689603: UCH proteinases |
Summary | |
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Symbol | TGFBR2 |
Name | transforming growth factor, beta receptor II (70/80kDa) |
Aliases | MFS2; transforming growth factor, beta receptor II (70-80kD); AAT3; FAA3; LDS1B; LDS2; LDS2B; RIIC; TAAD2; T ...... |
Chromosomal Location | 3p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TGFBR2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between TGFBR2 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | TGFBR2 |
Name | transforming growth factor, beta receptor II (70/80kDa) |
Aliases | MFS2; transforming growth factor, beta receptor II (70-80kD); AAT3; FAA3; LDS1B; LDS2; LDS2B; RIIC; TAAD2; T ...... |
Chromosomal Location | 3p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TGFBR2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TGFBR2 |
Name | transforming growth factor, beta receptor II (70/80kDa) |
Aliases | MFS2; transforming growth factor, beta receptor II (70-80kD); AAT3; FAA3; LDS1B; LDS2; LDS2B; RIIC; TAAD2; T ...... |
Chromosomal Location | 3p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TGFBR2 in various data sets.
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Points in the above scatter plot represent the mutation difference of TGFBR2 in various data sets.
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Summary | |
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Symbol | TGFBR2 |
Name | transforming growth factor, beta receptor II (70/80kDa) |
Aliases | MFS2; transforming growth factor, beta receptor II (70-80kD); AAT3; FAA3; LDS1B; LDS2; LDS2B; RIIC; TAAD2; T ...... |
Chromosomal Location | 3p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TGFBR2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | TGFBR2 |
Name | transforming growth factor, beta receptor II (70/80kDa) |
Aliases | MFS2; transforming growth factor, beta receptor II (70-80kD); AAT3; FAA3; LDS1B; LDS2; LDS2B; RIIC; TAAD2; T ...... |
Chromosomal Location | 3p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TGFBR2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TGFBR2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TGFBR2 |
Name | transforming growth factor, beta receptor II (70/80kDa) |
Aliases | MFS2; transforming growth factor, beta receptor II (70-80kD); AAT3; FAA3; LDS1B; LDS2; LDS2B; RIIC; TAAD2; T ...... |
Chromosomal Location | 3p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TGFBR2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | TGFBR2 |
Name | transforming growth factor, beta receptor II (70/80kDa) |
Aliases | MFS2; transforming growth factor, beta receptor II (70-80kD); AAT3; FAA3; LDS1B; LDS2; LDS2B; RIIC; TAAD2; T ...... |
Chromosomal Location | 3p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TGFBR2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | TGFBR2 |
Name | transforming growth factor, beta receptor II (70/80kDa) |
Aliases | MFS2; transforming growth factor, beta receptor II (70-80kD); AAT3; FAA3; LDS1B; LDS2; LDS2B; RIIC; TAAD2; T ...... |
Chromosomal Location | 3p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TGFBR2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | TGFBR2 |
Name | transforming growth factor, beta receptor II (70/80kDa) |
Aliases | MFS2; transforming growth factor, beta receptor II (70-80kD); AAT3; FAA3; LDS1B; LDS2; LDS2B; RIIC; TAAD2; T ...... |
Chromosomal Location | 3p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TGFBR2 collected from DrugBank database. |
Details on drugs targeting TGFBR2.
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