Browse TGIF1

Summary
SymbolTGIF1
NameTGFB-induced factor homeobox 1
Aliases HPE4; TGFB-induced factor (TALE family homeobox); 5'-TG-3'-interacting factor 1; TALE homeobox TG-interactin ......
Chromosomal Location18p11.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus.
Domain PF05920 Homeobox KN domain
Function

Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities.

> Gene Ontology
 
Biological Process GO:0042493 response to drug
Molecular Function GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001159 core promoter proximal region DNA binding
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003714 transcription corepressor activity
GO:0046332 SMAD binding
GO:0070410 co-SMAD binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04350 TGF-beta signaling pathway
Reactome R-HSA-2173795: Downregulation of SMAD2/3
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-2173796: SMAD2/SMAD3
R-HSA-162582: Signal Transduction
R-HSA-170834: Signaling by TGF-beta Receptor Complex
R-HSA-2173793: Transcriptional activity of SMAD2/SMAD3
Summary
SymbolTGIF1
NameTGFB-induced factor homeobox 1
Aliases HPE4; TGFB-induced factor (TALE family homeobox); 5'-TG-3'-interacting factor 1; TALE homeobox TG-interactin ......
Chromosomal Location18p11.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between TGIF1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolTGIF1
NameTGFB-induced factor homeobox 1
Aliases HPE4; TGFB-induced factor (TALE family homeobox); 5'-TG-3'-interacting factor 1; TALE homeobox TG-interactin ......
Chromosomal Location18p11.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of TGIF1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell logFC: -2.97; FDR: 0.02000 Resistant to T cell-mediated killing
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolTGIF1
NameTGFB-induced factor homeobox 1
Aliases HPE4; TGFB-induced factor (TALE family homeobox); 5'-TG-3'-interacting factor 1; TALE homeobox TG-interactin ......
Chromosomal Location18p11.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of TGIF1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1630.552
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.4640.854
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0590.974
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.3610.27
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.330.883
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.4090.894
729033130MelanomaallAnti-PD-1 (nivolumab) 262300.999
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0850.958
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.1140.95
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0260.989
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.0350.99
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.060.468
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of TGIF1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59200200.357
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolTGIF1
NameTGFB-induced factor homeobox 1
Aliases HPE4; TGFB-induced factor (TALE family homeobox); 5'-TG-3'-interacting factor 1; TALE homeobox TG-interactin ......
Chromosomal Location18p11.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TGIF1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolTGIF1
NameTGFB-induced factor homeobox 1
Aliases HPE4; TGFB-induced factor (TALE family homeobox); 5'-TG-3'-interacting factor 1; TALE homeobox TG-interactin ......
Chromosomal Location18p11.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TGIF1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TGIF1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolTGIF1
NameTGFB-induced factor homeobox 1
Aliases HPE4; TGFB-induced factor (TALE family homeobox); 5'-TG-3'-interacting factor 1; TALE homeobox TG-interactin ......
Chromosomal Location18p11.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TGIF1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolTGIF1
NameTGFB-induced factor homeobox 1
Aliases HPE4; TGFB-induced factor (TALE family homeobox); 5'-TG-3'-interacting factor 1; TALE homeobox TG-interactin ......
Chromosomal Location18p11.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of TGIF1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolTGIF1
NameTGFB-induced factor homeobox 1
Aliases HPE4; TGFB-induced factor (TALE family homeobox); 5'-TG-3'-interacting factor 1; TALE homeobox TG-interactin ......
Chromosomal Location18p11.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between TGIF1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolTGIF1
NameTGFB-induced factor homeobox 1
Aliases HPE4; TGFB-induced factor (TALE family homeobox); 5'-TG-3'-interacting factor 1; TALE homeobox TG-interactin ......
Chromosomal Location18p11.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting TGIF1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.