Summary | |
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Symbol | TGIF1 |
Name | TGFB-induced factor homeobox 1 |
Aliases | HPE4; TGFB-induced factor (TALE family homeobox); 5'-TG-3'-interacting factor 1; TALE homeobox TG-interactin ...... |
Chromosomal Location | 18p11.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. |
Domain |
PF05920 Homeobox KN domain |
Function |
Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities. |
Biological Process |
GO:0042493 response to drug |
Molecular Function |
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001159 core promoter proximal region DNA binding GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003714 transcription corepressor activity GO:0046332 SMAD binding GO:0070410 co-SMAD binding |
Cellular Component | - |
KEGG |
hsa04350 TGF-beta signaling pathway |
Reactome |
R-HSA-2173795: Downregulation of SMAD2/3 R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-2173796: SMAD2/SMAD3 R-HSA-162582: Signal Transduction R-HSA-170834: Signaling by TGF-beta Receptor Complex R-HSA-2173793: Transcriptional activity of SMAD2/SMAD3 |
Summary | |
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Symbol | TGIF1 |
Name | TGFB-induced factor homeobox 1 |
Aliases | HPE4; TGFB-induced factor (TALE family homeobox); 5'-TG-3'-interacting factor 1; TALE homeobox TG-interactin ...... |
Chromosomal Location | 18p11.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TGIF1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TGIF1 |
Name | TGFB-induced factor homeobox 1 |
Aliases | HPE4; TGFB-induced factor (TALE family homeobox); 5'-TG-3'-interacting factor 1; TALE homeobox TG-interactin ...... |
Chromosomal Location | 18p11.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TGIF1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TGIF1 |
Name | TGFB-induced factor homeobox 1 |
Aliases | HPE4; TGFB-induced factor (TALE family homeobox); 5'-TG-3'-interacting factor 1; TALE homeobox TG-interactin ...... |
Chromosomal Location | 18p11.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TGIF1 in various data sets.
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Points in the above scatter plot represent the mutation difference of TGIF1 in various data sets.
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Summary | |
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Symbol | TGIF1 |
Name | TGFB-induced factor homeobox 1 |
Aliases | HPE4; TGFB-induced factor (TALE family homeobox); 5'-TG-3'-interacting factor 1; TALE homeobox TG-interactin ...... |
Chromosomal Location | 18p11.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TGIF1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TGIF1 |
Name | TGFB-induced factor homeobox 1 |
Aliases | HPE4; TGFB-induced factor (TALE family homeobox); 5'-TG-3'-interacting factor 1; TALE homeobox TG-interactin ...... |
Chromosomal Location | 18p11.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TGIF1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TGIF1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TGIF1 |
Name | TGFB-induced factor homeobox 1 |
Aliases | HPE4; TGFB-induced factor (TALE family homeobox); 5'-TG-3'-interacting factor 1; TALE homeobox TG-interactin ...... |
Chromosomal Location | 18p11.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TGIF1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | TGIF1 |
Name | TGFB-induced factor homeobox 1 |
Aliases | HPE4; TGFB-induced factor (TALE family homeobox); 5'-TG-3'-interacting factor 1; TALE homeobox TG-interactin ...... |
Chromosomal Location | 18p11.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TGIF1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | TGIF1 |
Name | TGFB-induced factor homeobox 1 |
Aliases | HPE4; TGFB-induced factor (TALE family homeobox); 5'-TG-3'-interacting factor 1; TALE homeobox TG-interactin ...... |
Chromosomal Location | 18p11.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TGIF1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | TGIF1 |
Name | TGFB-induced factor homeobox 1 |
Aliases | HPE4; TGFB-induced factor (TALE family homeobox); 5'-TG-3'-interacting factor 1; TALE homeobox TG-interactin ...... |
Chromosomal Location | 18p11.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TGIF1 collected from DrugBank database. |
There is no record. |