Summary | |
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Symbol | TGIF2 |
Name | TGFB-induced factor homeobox 2 |
Aliases | TGFB-induced factor 2 (TALE family homeobox); 5'-TG-3' interacting factor 2; TGF(beta)-induced transcription ...... |
Chromosomal Location | 20q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. Note=Excluded from nucleoli. |
Domain |
PF05920 Homeobox KN domain |
Function |
Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins. |
Biological Process |
GO:0001654 eye development GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007369 gastrulation GO:0007423 sensory organ development GO:0010470 regulation of gastrulation GO:0010720 positive regulation of cell development GO:0032924 activin receptor signaling pathway GO:0038092 nodal signaling pathway GO:0043010 camera-type eye development GO:0045666 positive regulation of neuron differentiation GO:0045995 regulation of embryonic development GO:0050769 positive regulation of neurogenesis GO:0051962 positive regulation of nervous system development GO:0060041 retina development in camera-type eye |
Molecular Function | - |
Cellular Component | - |
KEGG |
hsa04350 TGF-beta signaling pathway |
Reactome |
R-HSA-2173795: Downregulation of SMAD2/3 R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-2173796: SMAD2/SMAD3 R-HSA-162582: Signal Transduction R-HSA-170834: Signaling by TGF-beta Receptor Complex R-HSA-2173793: Transcriptional activity of SMAD2/SMAD3 |
Summary | |
---|---|
Symbol | TGIF2 |
Name | TGFB-induced factor homeobox 2 |
Aliases | TGFB-induced factor 2 (TALE family homeobox); 5'-TG-3' interacting factor 2; TGF(beta)-induced transcription ...... |
Chromosomal Location | 20q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TGIF2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TGIF2 |
Name | TGFB-induced factor homeobox 2 |
Aliases | TGFB-induced factor 2 (TALE family homeobox); 5'-TG-3' interacting factor 2; TGF(beta)-induced transcription ...... |
Chromosomal Location | 20q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TGIF2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TGIF2 |
Name | TGFB-induced factor homeobox 2 |
Aliases | TGFB-induced factor 2 (TALE family homeobox); 5'-TG-3' interacting factor 2; TGF(beta)-induced transcription ...... |
Chromosomal Location | 20q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TGIF2 in various data sets.
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Points in the above scatter plot represent the mutation difference of TGIF2 in various data sets.
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Summary | |
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Symbol | TGIF2 |
Name | TGFB-induced factor homeobox 2 |
Aliases | TGFB-induced factor 2 (TALE family homeobox); 5'-TG-3' interacting factor 2; TGF(beta)-induced transcription ...... |
Chromosomal Location | 20q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TGIF2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TGIF2 |
Name | TGFB-induced factor homeobox 2 |
Aliases | TGFB-induced factor 2 (TALE family homeobox); 5'-TG-3' interacting factor 2; TGF(beta)-induced transcription ...... |
Chromosomal Location | 20q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TGIF2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TGIF2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TGIF2 |
Name | TGFB-induced factor homeobox 2 |
Aliases | TGFB-induced factor 2 (TALE family homeobox); 5'-TG-3' interacting factor 2; TGF(beta)-induced transcription ...... |
Chromosomal Location | 20q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TGIF2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TGIF2 |
Name | TGFB-induced factor homeobox 2 |
Aliases | TGFB-induced factor 2 (TALE family homeobox); 5'-TG-3' interacting factor 2; TGF(beta)-induced transcription ...... |
Chromosomal Location | 20q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TGIF2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TGIF2 |
Name | TGFB-induced factor homeobox 2 |
Aliases | TGFB-induced factor 2 (TALE family homeobox); 5'-TG-3' interacting factor 2; TGF(beta)-induced transcription ...... |
Chromosomal Location | 20q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TGIF2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TGIF2 |
Name | TGFB-induced factor homeobox 2 |
Aliases | TGFB-induced factor 2 (TALE family homeobox); 5'-TG-3' interacting factor 2; TGF(beta)-induced transcription ...... |
Chromosomal Location | 20q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TGIF2 collected from DrugBank database. |
There is no record. |