Summary | |
---|---|
Symbol | TH |
Name | tyrosine hydroxylase |
Aliases | DYT5b; tyrosine 3-monooxygenase; TYH; tyrosine 3-hydroxylase |
Chromosomal Location | 11p15.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF00351 Biopterin-dependent aromatic amino acid hydroxylase PF12549 Tyrosine hydroxylase N terminal |
Function |
Plays an important role in the physiology of adrenergic neurons. |
Biological Process |
GO:0001101 response to acid chemical GO:0001505 regulation of neurotransmitter levels GO:0001654 eye development GO:0001666 response to hypoxia GO:0001678 cellular glucose homeostasis GO:0001754 eye photoreceptor cell differentiation GO:0001963 synaptic transmission, dopaminergic GO:0001975 response to amphetamine GO:0002237 response to molecule of bacterial origin GO:0003007 heart morphogenesis GO:0003013 circulatory system process GO:0003015 heart process GO:0006570 tyrosine metabolic process GO:0006584 catecholamine metabolic process GO:0006585 dopamine biosynthetic process from tyrosine GO:0006631 fatty acid metabolic process GO:0006643 membrane lipid metabolic process GO:0006665 sphingolipid metabolic process GO:0006720 isoprenoid metabolic process GO:0006836 neurotransmitter transport GO:0006970 response to osmotic stress GO:0007270 neuron-neuron synaptic transmission GO:0007423 sensory organ development GO:0007507 heart development GO:0007568 aging GO:0007601 visual perception GO:0007605 sensory perception of sound GO:0007611 learning or memory GO:0007612 learning GO:0007613 memory GO:0007617 mating behavior GO:0007618 mating GO:0007622 rhythmic behavior GO:0007623 circadian rhythm GO:0007626 locomotory behavior GO:0007631 feeding behavior GO:0008015 blood circulation GO:0008016 regulation of heart contraction GO:0009072 aromatic amino acid family metabolic process GO:0009314 response to radiation GO:0009404 toxin metabolic process GO:0009414 response to water deprivation GO:0009415 response to water GO:0009416 response to light stimulus GO:0009635 response to herbicide GO:0009636 response to toxic substance GO:0009651 response to salt stress GO:0009712 catechol-containing compound metabolic process GO:0009713 catechol-containing compound biosynthetic process GO:0009743 response to carbohydrate GO:0009746 response to hexose GO:0009749 response to glucose GO:0009820 alkaloid metabolic process GO:0009991 response to extracellular stimulus GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0010042 response to manganese ion GO:0010043 response to zinc ion GO:0010259 multicellular organism aging GO:0014075 response to amine GO:0014823 response to activity GO:0015837 amine transport GO:0015842 aminergic neurotransmitter loading into synaptic vesicle GO:0016137 glycoside metabolic process GO:0017085 response to insecticide GO:0018958 phenol-containing compound metabolic process GO:0018963 phthalate metabolic process GO:0019098 reproductive behavior GO:0019748 secondary metabolic process GO:0021537 telencephalon development GO:0021543 pallium development GO:0021987 cerebral cortex development GO:0030900 forebrain development GO:0031076 embryonic camera-type eye development GO:0031667 response to nutrient levels GO:0031960 response to corticosteroid GO:0032355 response to estradiol GO:0032496 response to lipopolysaccharide GO:0033076 isoquinoline alkaloid metabolic process GO:0033500 carbohydrate homeostasis GO:0034284 response to monosaccharide GO:0035094 response to nicotine GO:0035176 social behavior GO:0035690 cellular response to drug GO:0035900 response to isolation stress GO:0035902 response to immobilization stress GO:0036293 response to decreased oxygen levels GO:0042133 neurotransmitter metabolic process GO:0042136 neurotransmitter biosynthetic process GO:0042214 terpene metabolic process GO:0042414 epinephrine metabolic process GO:0042415 norepinephrine metabolic process GO:0042416 dopamine biosynthetic process GO:0042417 dopamine metabolic process GO:0042418 epinephrine biosynthetic process GO:0042421 norepinephrine biosynthetic process GO:0042423 catecholamine biosynthetic process GO:0042461 photoreceptor cell development GO:0042462 eye photoreceptor cell development GO:0042493 response to drug GO:0042537 benzene-containing compound metabolic process GO:0042593 glucose homeostasis GO:0042745 circadian sleep/wake cycle GO:0042755 eating behavior GO:0043010 camera-type eye development GO:0043279 response to alkaloid GO:0043434 response to peptide hormone GO:0043473 pigmentation GO:0043648 dicarboxylic acid metabolic process GO:0044057 regulation of system process GO:0044708 single-organism behavior GO:0045471 response to ethanol GO:0045472 response to ether GO:0046189 phenol-containing compound biosynthetic process GO:0046530 photoreceptor cell differentiation GO:0046684 response to pyrethroid GO:0048048 embryonic eye morphogenesis GO:0048511 rhythmic process GO:0048512 circadian behavior GO:0048545 response to steroid hormone GO:0048562 embryonic organ morphogenesis GO:0048568 embryonic organ development GO:0048592 eye morphogenesis GO:0048593 camera-type eye morphogenesis GO:0048596 embryonic camera-type eye morphogenesis GO:0050890 cognition GO:0050953 sensory perception of light stimulus GO:0050954 sensory perception of mechanical stimulus GO:0051384 response to glucocorticoid GO:0051385 response to mineralocorticoid GO:0051412 response to corticosterone GO:0051602 response to electrical stimulus GO:0051703 intraspecies interaction between organisms GO:0051705 multi-organism behavior GO:0052314 phytoalexin metabolic process GO:0060047 heart contraction GO:0070482 response to oxygen levels GO:0071241 cellular response to inorganic substance GO:0071248 cellular response to metal ion GO:0071287 cellular response to manganese ion GO:0071312 cellular response to alkaloid GO:0071316 cellular response to nicotine GO:0071322 cellular response to carbohydrate stimulus GO:0071326 cellular response to monosaccharide stimulus GO:0071331 cellular response to hexose stimulus GO:0071333 cellular response to glucose stimulus GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0090596 sensory organ morphogenesis GO:0097305 response to alcohol GO:0098700 neurotransmitter loading into synaptic vesicle GO:0099504 synaptic vesicle cycle GO:1901605 alpha-amino acid metabolic process GO:1901615 organic hydroxy compound metabolic process GO:1901617 organic hydroxy compound biosynthetic process GO:1901652 response to peptide GO:1901654 response to ketone GO:1901657 glycosyl compound metabolic process GO:1903522 regulation of blood circulation GO:1990267 response to transition metal nanoparticle |
Molecular Function |
GO:0004497 monooxygenase activity GO:0004511 tyrosine 3-monooxygenase activity GO:0005506 iron ion binding GO:0008198 ferrous iron binding GO:0008199 ferric iron binding GO:0016597 amino acid binding GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen GO:0019825 oxygen binding GO:0031406 carboxylic acid binding GO:0034617 tetrahydrobiopterin binding GO:0035240 dopamine binding GO:0043168 anion binding GO:0048037 cofactor binding GO:0050662 coenzyme binding GO:1901338 catecholamine binding |
Cellular Component |
GO:0005790 smooth endoplasmic reticulum GO:0008021 synaptic vesicle GO:0009898 cytoplasmic side of plasma membrane GO:0030133 transport vesicle GO:0030424 axon GO:0030425 dendrite GO:0030659 cytoplasmic vesicle membrane GO:0033162 melanosome membrane GO:0033267 axon part GO:0042470 melanosome GO:0043025 neuronal cell body GO:0043195 terminal bouton GO:0043204 perikaryon GO:0043679 axon terminus GO:0044297 cell body GO:0044306 neuron projection terminus GO:0045009 chitosome GO:0048770 pigment granule GO:0070382 exocytic vesicle GO:0098552 side of membrane GO:0098562 cytoplasmic side of membrane GO:0098793 presynapse GO:0099503 secretory vesicle |
KEGG |
hsa04728 Dopaminergic synapse hsa04917 Prolactin signaling pathway hsa00350 Tyrosine metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-209776: Amine-derived hormones R-HSA-209905: Catecholamine biosynthesis R-HSA-1430728: Metabolism R-HSA-71291: Metabolism of amino acids and derivatives |
Summary | |
---|---|
Symbol | TH |
Name | tyrosine hydroxylase |
Aliases | DYT5b; tyrosine 3-monooxygenase; TYH; tyrosine 3-hydroxylase |
Chromosomal Location | 11p15.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TH and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TH |
Name | tyrosine hydroxylase |
Aliases | DYT5b; tyrosine 3-monooxygenase; TYH; tyrosine 3-hydroxylase |
Chromosomal Location | 11p15.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of TH in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | TH |
Name | tyrosine hydroxylase |
Aliases | DYT5b; tyrosine 3-monooxygenase; TYH; tyrosine 3-hydroxylase |
Chromosomal Location | 11p15.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TH in various data sets.
|
Points in the above scatter plot represent the mutation difference of TH in various data sets.
|
Summary | |
---|---|
Symbol | TH |
Name | tyrosine hydroxylase |
Aliases | DYT5b; tyrosine 3-monooxygenase; TYH; tyrosine 3-hydroxylase |
Chromosomal Location | 11p15.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TH. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TH |
Name | tyrosine hydroxylase |
Aliases | DYT5b; tyrosine 3-monooxygenase; TYH; tyrosine 3-hydroxylase |
Chromosomal Location | 11p15.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TH. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TH. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | TH |
Name | tyrosine hydroxylase |
Aliases | DYT5b; tyrosine 3-monooxygenase; TYH; tyrosine 3-hydroxylase |
Chromosomal Location | 11p15.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TH. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TH |
Name | tyrosine hydroxylase |
Aliases | DYT5b; tyrosine 3-monooxygenase; TYH; tyrosine 3-hydroxylase |
Chromosomal Location | 11p15.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TH expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TH |
Name | tyrosine hydroxylase |
Aliases | DYT5b; tyrosine 3-monooxygenase; TYH; tyrosine 3-hydroxylase |
Chromosomal Location | 11p15.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TH and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TH |
Name | tyrosine hydroxylase |
Aliases | DYT5b; tyrosine 3-monooxygenase; TYH; tyrosine 3-hydroxylase |
Chromosomal Location | 11p15.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TH collected from DrugBank database. |
Details on drugs targeting TH.
|