Summary | |
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Symbol | THBS3 |
Name | thrombospondin 3 |
Aliases | TSP3; Thrombospondin-3 |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF11598 Cartilage oligomeric matrix protein PF07645 Calcium-binding EGF domain PF02412 Thrombospondin type 3 repeat PF05735 Thrombospondin C-terminal region |
Function |
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen. |
Biological Process |
GO:0001501 skeletal system development GO:0001503 ossification GO:0003416 endochondral bone growth GO:0003417 growth plate cartilage development GO:0007160 cell-matrix adhesion GO:0021700 developmental maturation GO:0031589 cell-substrate adhesion GO:0035265 organ growth GO:0043931 ossification involved in bone maturation GO:0048705 skeletal system morphogenesis GO:0048799 animal organ maturation GO:0051216 cartilage development GO:0060343 trabecula formation GO:0060346 bone trabecula formation GO:0060348 bone development GO:0060349 bone morphogenesis GO:0060350 endochondral bone morphogenesis GO:0060351 cartilage development involved in endochondral bone morphogenesis GO:0061383 trabecula morphogenesis GO:0061430 bone trabecula morphogenesis GO:0061448 connective tissue development GO:0070977 bone maturation GO:0071695 anatomical structure maturation GO:0098868 bone growth |
Molecular Function |
GO:0005539 glycosaminoglycan binding GO:0008201 heparin binding GO:1901681 sulfur compound binding |
Cellular Component | - |
KEGG |
hsa04145 Phagosome hsa04151 PI3K-Akt signaling pathway hsa04510 Focal adhesion hsa04512 ECM-receptor interaction |
Reactome |
R-HSA-162582: Signal Transduction R-HSA-186797: Signaling by PDGF |
Summary | |
---|---|
Symbol | THBS3 |
Name | thrombospondin 3 |
Aliases | TSP3; Thrombospondin-3 |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between THBS3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | THBS3 |
Name | thrombospondin 3 |
Aliases | TSP3; Thrombospondin-3 |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of THBS3 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | THBS3 |
Name | thrombospondin 3 |
Aliases | TSP3; Thrombospondin-3 |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of THBS3 in various data sets.
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Points in the above scatter plot represent the mutation difference of THBS3 in various data sets.
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Summary | |
---|---|
Symbol | THBS3 |
Name | thrombospondin 3 |
Aliases | TSP3; Thrombospondin-3 |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of THBS3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | THBS3 |
Name | thrombospondin 3 |
Aliases | TSP3; Thrombospondin-3 |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of THBS3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by THBS3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | THBS3 |
Name | thrombospondin 3 |
Aliases | TSP3; Thrombospondin-3 |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of THBS3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | THBS3 |
Name | thrombospondin 3 |
Aliases | TSP3; Thrombospondin-3 |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of THBS3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | THBS3 |
Name | thrombospondin 3 |
Aliases | TSP3; Thrombospondin-3 |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between THBS3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |