Summary | |
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Symbol | THEM5 |
Name | thioesterase superfamily member 5 |
Aliases | FLJ37964; ACOT15; acyl-CoA thioesterase THEM5; acyl-coenzyme A thioesterase 15; Acyl-coenzyme A thioesterase ...... |
Chromosomal Location | 1q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Mitochondrion matrix |
Domain |
PF03061 Thioesterase superfamily |
Function |
Has acyl-CoA thioesterase activity towards long-chain (C16 and C18) fatty acyl-CoA substrates, with a preference for linoleoyl-CoA and other unsaturated long-chain fatty acid-CoA esters. Plays an important role in mitochondrial fatty acid metabolism, and in remodeling of the mitochondrial lipid cardiolipin. Required for normal mitochondrial function. |
Biological Process |
GO:0006631 fatty acid metabolic process GO:0006637 acyl-CoA metabolic process GO:0006644 phospholipid metabolic process GO:0006650 glycerophospholipid metabolic process GO:0006732 coenzyme metabolic process GO:0006790 sulfur compound metabolic process GO:0009108 coenzyme biosynthetic process GO:0032048 cardiolipin metabolic process GO:0035336 long-chain fatty-acyl-CoA metabolic process GO:0035337 fatty-acyl-CoA metabolic process GO:0035338 long-chain fatty-acyl-CoA biosynthetic process GO:0035383 thioester metabolic process GO:0035384 thioester biosynthetic process GO:0035965 cardiolipin acyl-chain remodeling GO:0044272 sulfur compound biosynthetic process GO:0046471 phosphatidylglycerol metabolic process GO:0046486 glycerolipid metabolic process GO:0046949 fatty-acyl-CoA biosynthetic process GO:0051186 cofactor metabolic process GO:0051188 cofactor biosynthetic process GO:0071616 acyl-CoA biosynthetic process |
Molecular Function |
GO:0016289 CoA hydrolase activity GO:0016290 palmitoyl-CoA hydrolase activity GO:0016790 thiolester hydrolase activity GO:0047617 acyl-CoA hydrolase activity |
Cellular Component |
GO:0005759 mitochondrial matrix |
KEGG | - |
Reactome |
R-HSA-75105: Fatty Acyl-CoA Biosynthesis R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-75109: Triglyceride Biosynthesis |
Summary | |
---|---|
Symbol | THEM5 |
Name | thioesterase superfamily member 5 |
Aliases | FLJ37964; ACOT15; acyl-CoA thioesterase THEM5; acyl-coenzyme A thioesterase 15; Acyl-coenzyme A thioesterase ...... |
Chromosomal Location | 1q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between THEM5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | THEM5 |
Name | thioesterase superfamily member 5 |
Aliases | FLJ37964; ACOT15; acyl-CoA thioesterase THEM5; acyl-coenzyme A thioesterase 15; Acyl-coenzyme A thioesterase ...... |
Chromosomal Location | 1q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of THEM5 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | THEM5 |
Name | thioesterase superfamily member 5 |
Aliases | FLJ37964; ACOT15; acyl-CoA thioesterase THEM5; acyl-coenzyme A thioesterase 15; Acyl-coenzyme A thioesterase ...... |
Chromosomal Location | 1q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of THEM5 in various data sets.
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Points in the above scatter plot represent the mutation difference of THEM5 in various data sets.
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Summary | |
---|---|
Symbol | THEM5 |
Name | thioesterase superfamily member 5 |
Aliases | FLJ37964; ACOT15; acyl-CoA thioesterase THEM5; acyl-coenzyme A thioesterase 15; Acyl-coenzyme A thioesterase ...... |
Chromosomal Location | 1q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of THEM5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | THEM5 |
Name | thioesterase superfamily member 5 |
Aliases | FLJ37964; ACOT15; acyl-CoA thioesterase THEM5; acyl-coenzyme A thioesterase 15; Acyl-coenzyme A thioesterase ...... |
Chromosomal Location | 1q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of THEM5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by THEM5. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | THEM5 |
Name | thioesterase superfamily member 5 |
Aliases | FLJ37964; ACOT15; acyl-CoA thioesterase THEM5; acyl-coenzyme A thioesterase 15; Acyl-coenzyme A thioesterase ...... |
Chromosomal Location | 1q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of THEM5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | THEM5 |
Name | thioesterase superfamily member 5 |
Aliases | FLJ37964; ACOT15; acyl-CoA thioesterase THEM5; acyl-coenzyme A thioesterase 15; Acyl-coenzyme A thioesterase ...... |
Chromosomal Location | 1q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of THEM5 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | THEM5 |
Name | thioesterase superfamily member 5 |
Aliases | FLJ37964; ACOT15; acyl-CoA thioesterase THEM5; acyl-coenzyme A thioesterase 15; Acyl-coenzyme A thioesterase ...... |
Chromosomal Location | 1q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between THEM5 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | THEM5 |
Name | thioesterase superfamily member 5 |
Aliases | FLJ37964; ACOT15; acyl-CoA thioesterase THEM5; acyl-coenzyme A thioesterase 15; Acyl-coenzyme A thioesterase ...... |
Chromosomal Location | 1q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting THEM5 collected from DrugBank database. |
There is no record. |