TISIDB

Summary
Symbol	THOC5
Name	THO complex 5
Aliases	PK1.3; KIAA0983; Fmip; fSAP79; functional spliceosome-associated protein 79; C22orf19; chromosome 22 open re ......
Chromosomal Location	22q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Nucleus Cytoplasm Note=Shuttles between nucleus and cytoplasm.
Domain	PF09766 Fms-interacting protein
Function	Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes; probably mediates association of the TREX and CFIm complexes.; FUNCTION: Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development.

> Gene Ontology [ TOP ]
Biological Process	GO:0000075 cell cycle checkpoint GO:0000077 DNA damage checkpoint GO:0002521 leukocyte differentiation GO:0002573 myeloid leukocyte differentiation GO:0006353 DNA-templated transcription, termination GO:0006354 DNA-templated transcription, elongation GO:0006369 termination of RNA polymerase II transcription GO:0006397 mRNA processing GO:0006403 RNA localization GO:0006405 RNA export from nucleus GO:0006406 mRNA export from nucleus GO:0006913 nucleocytoplasmic transport GO:0008380 RNA splicing GO:0010948 negative regulation of cell cycle process GO:0015931 nucleobase-containing compound transport GO:0019058 viral life cycle GO:0030099 myeloid cell differentiation GO:0030224 monocyte differentiation GO:0031123 RNA 3'-end processing GO:0031124 mRNA 3'-end processing GO:0031570 DNA integrity checkpoint GO:0032784 regulation of DNA-templated transcription, elongation GO:0032786 positive regulation of DNA-templated transcription, elongation GO:0035162 embryonic hemopoiesis GO:0044766 multi-organism transport GO:0045786 negative regulation of cell cycle GO:0046784 viral mRNA export from host cell nucleus GO:0046794 transport of virus GO:0048568 embryonic organ development GO:0050657 nucleic acid transport GO:0050658 RNA transport GO:0051028 mRNA transport GO:0051168 nuclear export GO:0051169 nuclear transport GO:0051236 establishment of RNA localization GO:0060215 primitive hemopoiesis GO:0071166 ribonucleoprotein complex localization GO:0071426 ribonucleoprotein complex export from nucleus GO:0071427 mRNA-containing ribonucleoprotein complex export from nucleus GO:0075733 intracellular transport of virus GO:1901976 regulation of cell cycle checkpoint GO:1901977 negative regulation of cell cycle checkpoint GO:1902579 multi-organism localization GO:1902581 multi-organism cellular localization GO:1902583 multi-organism intracellular transport GO:1903131 mononuclear cell differentiation GO:2000001 regulation of DNA damage checkpoint GO:2000002 negative regulation of DNA damage checkpoint GO:2001020 regulation of response to DNA damage stimulus GO:2001021 negative regulation of response to DNA damage stimulus
Molecular Function	GO:0003729 mRNA binding
Cellular Component	GO:0000346 transcription export complex GO:0000347 THO complex GO:0000445 THO complex part of transcription export complex GO:0000781 chromosome, telomeric region GO:0000784 nuclear chromosome, telomeric region GO:0044454 nuclear chromosome part GO:0098687 chromosomal region

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa03013 RNA transport
Reactome	R-HSA-109688: Cleavage of Growing Transcript in the Termination Region R-HSA-74160: Gene Expression R-HSA-112296: Post-Elongation Processing of Intron-Containing pre-mRNA R-HSA-76044: Post-Elongation Processing of the Transcript R-HSA-72203: Processing of Capped Intron-Containing Pre-mRNA R-HSA-73857: RNA Polymerase II Transcription R-HSA-73856: RNA Polymerase II Transcription Termination R-HSA-72202: Transport of Mature Transcript to Cytoplasm R-HSA-159236: Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72187: mRNA 3'-end processing

> KEGG and Reactome Pathway

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KEGG

hsa03013 RNA transport

Reactome

R-HSA-109688: Cleavage of Growing Transcript in the Termination Region
R-HSA-74160: Gene Expression
R-HSA-112296: Post-Elongation Processing of Intron-Containing pre-mRNA
R-HSA-76044: Post-Elongation Processing of the Transcript
R-HSA-72203: Processing of Capped Intron-Containing Pre-mRNA
R-HSA-73857: RNA Polymerase II Transcription
R-HSA-73856: RNA Polymerase II Transcription Termination
R-HSA-72202: Transport of Mature Transcript to Cytoplasm
R-HSA-159236: Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72187: mRNA 3'-end processing

Summary
Symbol	THOC5
Name	THO complex 5
Aliases	PK1.3; KIAA0983; Fmip; fSAP79; functional spliceosome-associated protein 79; C22orf19; chromosome 22 open re ......
Chromosomal Location	22q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between THOC5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	THOC5
Name	THO complex 5
Aliases	PK1.3; KIAA0983; Fmip; fSAP79; functional spliceosome-associated protein 79; C22orf19; chromosome 22 open re ......
Chromosomal Location	22q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of THOC5 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	THOC5
Name	THO complex 5
Aliases	PK1.3; KIAA0983; Fmip; fSAP79; functional spliceosome-associated protein 79; C22orf19; chromosome 22 open re ......
Chromosomal Location	22q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of THOC5 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.114	0.665
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.25	0.892
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.021	0.988
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.019	0.955
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.266	0.893
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.384	0.883
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.161	0.685
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.034	0.982
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.398	0.811
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.538	0.662
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.812	0.675
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.016	0.785

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of THOC5 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	5.9	-5.9	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	7.1	-7.1	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	11.1	0	11.1	0.0181
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	11.1	0	11.1	0.0286
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	4.8	0	4.8	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	7.7	0	7.7	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	THOC5
Name	THO complex 5
Aliases	PK1.3; KIAA0983; Fmip; fSAP79; functional spliceosome-associated protein 79; C22orf19; chromosome 22 open re ......
Chromosomal Location	22q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of THOC5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	THOC5
Name	THO complex 5
Aliases	PK1.3; KIAA0983; Fmip; fSAP79; functional spliceosome-associated protein 79; C22orf19; chromosome 22 open re ......
Chromosomal Location	22q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of THOC5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by THOC5. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	THOC5
Name	THO complex 5
Aliases	PK1.3; KIAA0983; Fmip; fSAP79; functional spliceosome-associated protein 79; C22orf19; chromosome 22 open re ......
Chromosomal Location	22q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of THOC5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	THOC5
Name	THO complex 5
Aliases	PK1.3; KIAA0983; Fmip; fSAP79; functional spliceosome-associated protein 79; C22orf19; chromosome 22 open re ......
Chromosomal Location	22q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of THOC5 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	THOC5
Name	THO complex 5
Aliases	PK1.3; KIAA0983; Fmip; fSAP79; functional spliceosome-associated protein 79; C22orf19; chromosome 22 open re ......
Chromosomal Location	22q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between THOC5 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	THOC5
Name	THO complex 5
Aliases	PK1.3; KIAA0983; Fmip; fSAP79; functional spliceosome-associated protein 79; C22orf19; chromosome 22 open re ......
Chromosomal Location	22q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting THOC5 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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