Summary | |
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Symbol | TIGIT |
Name | T cell immunoreceptor with Ig and ITIM domains |
Aliases | FLJ39873; DKFZp667A205; VSIG9; VSTM3; V-set and immunoglobulin domain containing 9; V-set and transmembrane ...... |
Chromosomal Location | 3q13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type I membrane protein |
Domain |
PF07686 Immunoglobulin V-set domain |
Function |
Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. |
Biological Process |
GO:0001818 negative regulation of cytokine production GO:0001819 positive regulation of cytokine production GO:0002683 negative regulation of immune system process GO:0002694 regulation of leukocyte activation GO:0002695 negative regulation of leukocyte activation GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007159 leukocyte cell-cell adhesion GO:0007162 negative regulation of cell adhesion GO:0008037 cell recognition GO:0022407 regulation of cell-cell adhesion GO:0022408 negative regulation of cell-cell adhesion GO:0032613 interleukin-10 production GO:0032615 interleukin-12 production GO:0032653 regulation of interleukin-10 production GO:0032655 regulation of interleukin-12 production GO:0032695 negative regulation of interleukin-12 production GO:0032733 positive regulation of interleukin-10 production GO:0042110 T cell activation GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050866 negative regulation of cell activation GO:0050868 negative regulation of T cell activation GO:0051249 regulation of lymphocyte activation GO:0051250 negative regulation of lymphocyte activation GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0071593 lymphocyte aggregation GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903038 negative regulation of leukocyte cell-cell adhesion |
Molecular Function |
GO:0050839 cell adhesion molecule binding |
Cellular Component |
GO:0005913 cell-cell adherens junction |
KEGG |
hsa04514 Cell adhesion molecules (CAMs) |
Reactome | - |
Summary | |
---|---|
Symbol | TIGIT |
Name | T cell immunoreceptor with Ig and ITIM domains |
Aliases | FLJ39873; DKFZp667A205; VSIG9; VSTM3; V-set and immunoglobulin domain containing 9; V-set and transmembrane ...... |
Chromosomal Location | 3q13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TIGIT and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between TIGIT and anti-tumor immunity in human cancer.
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Summary | |
---|---|
Symbol | TIGIT |
Name | T cell immunoreceptor with Ig and ITIM domains |
Aliases | FLJ39873; DKFZp667A205; VSIG9; VSTM3; V-set and immunoglobulin domain containing 9; V-set and transmembrane ...... |
Chromosomal Location | 3q13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TIGIT in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TIGIT |
Name | T cell immunoreceptor with Ig and ITIM domains |
Aliases | FLJ39873; DKFZp667A205; VSIG9; VSTM3; V-set and immunoglobulin domain containing 9; V-set and transmembrane ...... |
Chromosomal Location | 3q13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TIGIT in various data sets.
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Points in the above scatter plot represent the mutation difference of TIGIT in various data sets.
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Summary | |
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Symbol | TIGIT |
Name | T cell immunoreceptor with Ig and ITIM domains |
Aliases | FLJ39873; DKFZp667A205; VSIG9; VSTM3; V-set and immunoglobulin domain containing 9; V-set and transmembrane ...... |
Chromosomal Location | 3q13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TIGIT. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TIGIT |
Name | T cell immunoreceptor with Ig and ITIM domains |
Aliases | FLJ39873; DKFZp667A205; VSIG9; VSTM3; V-set and immunoglobulin domain containing 9; V-set and transmembrane ...... |
Chromosomal Location | 3q13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TIGIT. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TIGIT. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | TIGIT |
Name | T cell immunoreceptor with Ig and ITIM domains |
Aliases | FLJ39873; DKFZp667A205; VSIG9; VSTM3; V-set and immunoglobulin domain containing 9; V-set and transmembrane ...... |
Chromosomal Location | 3q13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TIGIT. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | TIGIT |
Name | T cell immunoreceptor with Ig and ITIM domains |
Aliases | FLJ39873; DKFZp667A205; VSIG9; VSTM3; V-set and immunoglobulin domain containing 9; V-set and transmembrane ...... |
Chromosomal Location | 3q13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TIGIT expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | TIGIT |
Name | T cell immunoreceptor with Ig and ITIM domains |
Aliases | FLJ39873; DKFZp667A205; VSIG9; VSTM3; V-set and immunoglobulin domain containing 9; V-set and transmembrane ...... |
Chromosomal Location | 3q13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TIGIT and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TIGIT |
Name | T cell immunoreceptor with Ig and ITIM domains |
Aliases | FLJ39873; DKFZp667A205; VSIG9; VSTM3; V-set and immunoglobulin domain containing 9; V-set and transmembrane ...... |
Chromosomal Location | 3q13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TIGIT collected from DrugBank database. |
There is no record. |