Summary | |
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Symbol | TIMP1 |
Name | TIMP metallopeptidase inhibitor 1 |
Aliases | TIMP; CLGI; tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor) ...... |
Chromosomal Location | Xp11.3-p11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted |
Domain |
PF00965 Tissue inhibitor of metalloproteinase |
Function |
Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. |
Biological Process |
GO:0001501 skeletal system development GO:0001667 ameboidal-type cell migration GO:0002576 platelet degranulation GO:0006509 membrane protein ectodomain proteolysis GO:0006887 exocytosis GO:0007229 integrin-mediated signaling pathway GO:0007565 female pregnancy GO:0007566 embryo implantation GO:0007568 aging GO:0009894 regulation of catabolic process GO:0009895 negative regulation of catabolic process GO:0010466 negative regulation of peptidase activity GO:0010951 negative regulation of endopeptidase activity GO:0022617 extracellular matrix disassembly GO:0030198 extracellular matrix organization GO:0030336 negative regulation of cell migration GO:0031329 regulation of cellular catabolic process GO:0031330 negative regulation of cellular catabolic process GO:0033619 membrane protein proteolysis GO:0040013 negative regulation of locomotion GO:0042176 regulation of protein catabolic process GO:0042177 negative regulation of protein catabolic process GO:0043062 extracellular structure organization GO:0043434 response to peptide hormone GO:0043900 regulation of multi-organism process GO:0043901 negative regulation of multi-organism process GO:0044706 multi-multicellular organism process GO:0045055 regulated exocytosis GO:0045861 negative regulation of proteolysis GO:0051043 regulation of membrane protein ectodomain proteolysis GO:0051045 negative regulation of membrane protein ectodomain proteolysis GO:0051216 cartilage development GO:0051271 negative regulation of cellular component movement GO:0051346 negative regulation of hydrolase activity GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0061448 connective tissue development GO:0061450 trophoblast cell migration GO:1901163 regulation of trophoblast cell migration GO:1901164 negative regulation of trophoblast cell migration GO:1901652 response to peptide GO:2000146 negative regulation of cell motility GO:2000241 regulation of reproductive process GO:2000242 negative regulation of reproductive process GO:2001044 regulation of integrin-mediated signaling pathway |
Molecular Function |
GO:0002020 protease binding GO:0004857 enzyme inhibitor activity GO:0004866 endopeptidase inhibitor activity GO:0005125 cytokine activity GO:0008083 growth factor activity GO:0008191 metalloendopeptidase inhibitor activity GO:0030414 peptidase inhibitor activity GO:0061134 peptidase regulator activity GO:0061135 endopeptidase regulator activity |
Cellular Component |
GO:0005578 proteinaceous extracellular matrix GO:0005604 basement membrane GO:0030141 secretory granule GO:0031091 platelet alpha granule GO:0031093 platelet alpha granule lumen GO:0031983 vesicle lumen GO:0034774 secretory granule lumen GO:0044420 extracellular matrix component GO:0060205 cytoplasmic membrane-bounded vesicle lumen GO:0099503 secretory vesicle |
KEGG |
hsa04066 HIF-1 signaling pathway |
Reactome |
R-HSA-1592389: Activation of Matrix Metalloproteinases R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-1474228: Degradation of the extracellular matrix R-HSA-1474244: Extracellular matrix organization R-HSA-109582: Hemostasis R-HSA-168256: Immune System R-HSA-6783783: Interleukin-10 signaling R-HSA-6785807: Interleukin-4 and 13 signaling R-HSA-76002: Platelet activation, signaling and aggregation R-HSA-114608: Platelet degranulation R-HSA-76005: Response to elevated platelet cytosolic Ca2+ R-HSA-449147: Signaling by Interleukins |
Summary | |
---|---|
Symbol | TIMP1 |
Name | TIMP metallopeptidase inhibitor 1 |
Aliases | TIMP; CLGI; tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor) ...... |
Chromosomal Location | Xp11.3-p11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TIMP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TIMP1 |
Name | TIMP metallopeptidase inhibitor 1 |
Aliases | TIMP; CLGI; tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor) ...... |
Chromosomal Location | Xp11.3-p11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TIMP1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | TIMP1 |
Name | TIMP metallopeptidase inhibitor 1 |
Aliases | TIMP; CLGI; tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor) ...... |
Chromosomal Location | Xp11.3-p11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TIMP1 in various data sets.
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Points in the above scatter plot represent the mutation difference of TIMP1 in various data sets.
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Summary | |
---|---|
Symbol | TIMP1 |
Name | TIMP metallopeptidase inhibitor 1 |
Aliases | TIMP; CLGI; tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor) ...... |
Chromosomal Location | Xp11.3-p11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TIMP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TIMP1 |
Name | TIMP metallopeptidase inhibitor 1 |
Aliases | TIMP; CLGI; tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor) ...... |
Chromosomal Location | Xp11.3-p11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TIMP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TIMP1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | TIMP1 |
Name | TIMP metallopeptidase inhibitor 1 |
Aliases | TIMP; CLGI; tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor) ...... |
Chromosomal Location | Xp11.3-p11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TIMP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TIMP1 |
Name | TIMP metallopeptidase inhibitor 1 |
Aliases | TIMP; CLGI; tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor) ...... |
Chromosomal Location | Xp11.3-p11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TIMP1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TIMP1 |
Name | TIMP metallopeptidase inhibitor 1 |
Aliases | TIMP; CLGI; tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor) ...... |
Chromosomal Location | Xp11.3-p11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TIMP1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TIMP1 |
Name | TIMP metallopeptidase inhibitor 1 |
Aliases | TIMP; CLGI; tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor) ...... |
Chromosomal Location | Xp11.3-p11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TIMP1 collected from DrugBank database. |
There is no record. |