Summary | |
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Symbol | TIMP3 |
Name | TIMP metallopeptidase inhibitor 3 |
Aliases | tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory); HSMRK222; K222; K222T ...... |
Chromosomal Location | 22q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted, extracellular space, extracellular matrix. |
Domain |
PF00965 Tissue inhibitor of metalloproteinase |
Function |
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15. |
Biological Process |
GO:0001933 negative regulation of protein phosphorylation GO:0002576 platelet degranulation GO:0006509 membrane protein ectodomain proteolysis GO:0006887 exocytosis GO:0007601 visual perception GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors GO:0009894 regulation of catabolic process GO:0009895 negative regulation of catabolic process GO:0010466 negative regulation of peptidase activity GO:0010951 negative regulation of endopeptidase activity GO:0031329 regulation of cellular catabolic process GO:0031330 negative regulation of cellular catabolic process GO:0033619 membrane protein proteolysis GO:0036462 TRAIL-activated apoptotic signaling pathway GO:0042176 regulation of protein catabolic process GO:0042177 negative regulation of protein catabolic process GO:0042326 negative regulation of phosphorylation GO:0043409 negative regulation of MAPK cascade GO:0045055 regulated exocytosis GO:0045861 negative regulation of proteolysis GO:0050953 sensory perception of light stimulus GO:0051043 regulation of membrane protein ectodomain proteolysis GO:0051045 negative regulation of membrane protein ectodomain proteolysis GO:0051346 negative regulation of hydrolase activity GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0070371 ERK1 and ERK2 cascade GO:0070372 regulation of ERK1 and ERK2 cascade GO:0070373 negative regulation of ERK1 and ERK2 cascade GO:0097191 extrinsic apoptotic signaling pathway GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902532 negative regulation of intracellular signal transduction GO:1903121 regulation of TRAIL-activated apoptotic signaling pathway GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway GO:1904683 regulation of metalloendopeptidase activity GO:1904684 negative regulation of metalloendopeptidase activity GO:1905048 regulation of metallopeptidase activity GO:1905049 negative regulation of metallopeptidase activity GO:2001233 regulation of apoptotic signaling pathway GO:2001235 positive regulation of apoptotic signaling pathway GO:2001236 regulation of extrinsic apoptotic signaling pathway GO:2001238 positive regulation of extrinsic apoptotic signaling pathway |
Molecular Function |
GO:0002020 protease binding GO:0004857 enzyme inhibitor activity GO:0004866 endopeptidase inhibitor activity GO:0008191 metalloendopeptidase inhibitor activity GO:0030414 peptidase inhibitor activity GO:0061134 peptidase regulator activity GO:0061135 endopeptidase regulator activity |
Cellular Component |
GO:0005578 proteinaceous extracellular matrix GO:0005604 basement membrane GO:0030141 secretory granule GO:0031089 platelet dense granule lumen GO:0031983 vesicle lumen GO:0034774 secretory granule lumen GO:0042827 platelet dense granule GO:0044420 extracellular matrix component GO:0060205 cytoplasmic membrane-bounded vesicle lumen GO:0099503 secretory vesicle |
KEGG | - |
Reactome |
R-HSA-109582: Hemostasis R-HSA-76002: Platelet activation, signaling and aggregation R-HSA-114608: Platelet degranulation R-HSA-76005: Response to elevated platelet cytosolic Ca2+ |
Summary | |
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Symbol | TIMP3 |
Name | TIMP metallopeptidase inhibitor 3 |
Aliases | tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory); HSMRK222; K222; K222T ...... |
Chromosomal Location | 22q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TIMP3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TIMP3 |
Name | TIMP metallopeptidase inhibitor 3 |
Aliases | tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory); HSMRK222; K222; K222T ...... |
Chromosomal Location | 22q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TIMP3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TIMP3 |
Name | TIMP metallopeptidase inhibitor 3 |
Aliases | tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory); HSMRK222; K222; K222T ...... |
Chromosomal Location | 22q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TIMP3 in various data sets.
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Points in the above scatter plot represent the mutation difference of TIMP3 in various data sets.
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Summary | |
---|---|
Symbol | TIMP3 |
Name | TIMP metallopeptidase inhibitor 3 |
Aliases | tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory); HSMRK222; K222; K222T ...... |
Chromosomal Location | 22q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TIMP3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TIMP3 |
Name | TIMP metallopeptidase inhibitor 3 |
Aliases | tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory); HSMRK222; K222; K222T ...... |
Chromosomal Location | 22q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TIMP3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TIMP3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TIMP3 |
Name | TIMP metallopeptidase inhibitor 3 |
Aliases | tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory); HSMRK222; K222; K222T ...... |
Chromosomal Location | 22q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TIMP3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TIMP3 |
Name | TIMP metallopeptidase inhibitor 3 |
Aliases | tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory); HSMRK222; K222; K222T ...... |
Chromosomal Location | 22q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TIMP3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TIMP3 |
Name | TIMP metallopeptidase inhibitor 3 |
Aliases | tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory); HSMRK222; K222; K222T ...... |
Chromosomal Location | 22q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TIMP3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TIMP3 |
Name | TIMP metallopeptidase inhibitor 3 |
Aliases | tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory); HSMRK222; K222; K222T ...... |
Chromosomal Location | 22q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TIMP3 collected from DrugBank database. |
Details on drugs targeting TIMP3.
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