Summary | |
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Symbol | TINAGL1 |
Name | tubulointerstitial nephritis antigen-like 1 |
Aliases | P3ECSL; LIECG3; TINAGRP; LCN7; lipocalin 7; TINAG-like 1; OLRG-2; TIN Ag-related protein; TIN-Ag-RP; androge ...... |
Chromosomal Location | 1p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted |
Domain |
PF00112 Papain family cysteine protease |
Function |
May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein (By similarity). |
Biological Process |
GO:0006898 receptor-mediated endocytosis GO:0007034 vacuolar transport GO:0016197 endosomal transport |
Molecular Function |
GO:0001871 pattern binding GO:0005044 scavenger receptor activity GO:0005201 extracellular matrix structural constituent GO:0030246 carbohydrate binding GO:0030247 polysaccharide binding GO:0038024 cargo receptor activity GO:0043236 laminin binding GO:0050840 extracellular matrix binding |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | TINAGL1 |
Name | tubulointerstitial nephritis antigen-like 1 |
Aliases | P3ECSL; LIECG3; TINAGRP; LCN7; lipocalin 7; TINAG-like 1; OLRG-2; TIN Ag-related protein; TIN-Ag-RP; androge ...... |
Chromosomal Location | 1p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TINAGL1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TINAGL1 |
Name | tubulointerstitial nephritis antigen-like 1 |
Aliases | P3ECSL; LIECG3; TINAGRP; LCN7; lipocalin 7; TINAG-like 1; OLRG-2; TIN Ag-related protein; TIN-Ag-RP; androge ...... |
Chromosomal Location | 1p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TINAGL1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TINAGL1 |
Name | tubulointerstitial nephritis antigen-like 1 |
Aliases | P3ECSL; LIECG3; TINAGRP; LCN7; lipocalin 7; TINAG-like 1; OLRG-2; TIN Ag-related protein; TIN-Ag-RP; androge ...... |
Chromosomal Location | 1p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TINAGL1 in various data sets.
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Points in the above scatter plot represent the mutation difference of TINAGL1 in various data sets.
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Summary | |
---|---|
Symbol | TINAGL1 |
Name | tubulointerstitial nephritis antigen-like 1 |
Aliases | P3ECSL; LIECG3; TINAGRP; LCN7; lipocalin 7; TINAG-like 1; OLRG-2; TIN Ag-related protein; TIN-Ag-RP; androge ...... |
Chromosomal Location | 1p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TINAGL1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | TINAGL1 |
Name | tubulointerstitial nephritis antigen-like 1 |
Aliases | P3ECSL; LIECG3; TINAGRP; LCN7; lipocalin 7; TINAG-like 1; OLRG-2; TIN Ag-related protein; TIN-Ag-RP; androge ...... |
Chromosomal Location | 1p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TINAGL1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TINAGL1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TINAGL1 |
Name | tubulointerstitial nephritis antigen-like 1 |
Aliases | P3ECSL; LIECG3; TINAGRP; LCN7; lipocalin 7; TINAG-like 1; OLRG-2; TIN Ag-related protein; TIN-Ag-RP; androge ...... |
Chromosomal Location | 1p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TINAGL1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | TINAGL1 |
Name | tubulointerstitial nephritis antigen-like 1 |
Aliases | P3ECSL; LIECG3; TINAGRP; LCN7; lipocalin 7; TINAG-like 1; OLRG-2; TIN Ag-related protein; TIN-Ag-RP; androge ...... |
Chromosomal Location | 1p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TINAGL1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TINAGL1 |
Name | tubulointerstitial nephritis antigen-like 1 |
Aliases | P3ECSL; LIECG3; TINAGRP; LCN7; lipocalin 7; TINAG-like 1; OLRG-2; TIN Ag-related protein; TIN-Ag-RP; androge ...... |
Chromosomal Location | 1p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TINAGL1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TINAGL1 |
Name | tubulointerstitial nephritis antigen-like 1 |
Aliases | P3ECSL; LIECG3; TINAGRP; LCN7; lipocalin 7; TINAG-like 1; OLRG-2; TIN Ag-related protein; TIN-Ag-RP; androge ...... |
Chromosomal Location | 1p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TINAGL1 collected from DrugBank database. |
There is no record. |