Summary | |
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Symbol | TJP3 |
Name | tight junction protein 3 |
Aliases | ZO-3; zona occludens 3; ZO3; tight junction protein 3 (zona occludens 3); zona occludens protein 3; zonula o ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Peripheral membrane protein Cytoplasmic side Cell junction, tight junction Nucleus Note=Exhibits predominant nuclear expression in proliferating cells but is exclusively junctionally expressed after confluence is reached (PubMed:23608536). Shows an epithelial-specific tight junction localization in a TJP1/TJP2-dependent fashion (By similarity). |
Domain |
PF00625 Guanylate kinase PF00595 PDZ domain (Also known as DHR or GLGF) PF07653 Variant SH3 domain |
Function |
TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates to the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity). |
Biological Process | - |
Molecular Function | - |
Cellular Component |
GO:0005923 bicellular tight junction GO:0043296 apical junction complex GO:0070160 occluding junction |
KEGG |
hsa04530 Tight junction |
Reactome | - |
Summary | |
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Symbol | TJP3 |
Name | tight junction protein 3 |
Aliases | ZO-3; zona occludens 3; ZO3; tight junction protein 3 (zona occludens 3); zona occludens protein 3; zonula o ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TJP3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TJP3 |
Name | tight junction protein 3 |
Aliases | ZO-3; zona occludens 3; ZO3; tight junction protein 3 (zona occludens 3); zona occludens protein 3; zonula o ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TJP3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TJP3 |
Name | tight junction protein 3 |
Aliases | ZO-3; zona occludens 3; ZO3; tight junction protein 3 (zona occludens 3); zona occludens protein 3; zonula o ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TJP3 in various data sets.
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Points in the above scatter plot represent the mutation difference of TJP3 in various data sets.
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Summary | |
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Symbol | TJP3 |
Name | tight junction protein 3 |
Aliases | ZO-3; zona occludens 3; ZO3; tight junction protein 3 (zona occludens 3); zona occludens protein 3; zonula o ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TJP3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | TJP3 |
Name | tight junction protein 3 |
Aliases | ZO-3; zona occludens 3; ZO3; tight junction protein 3 (zona occludens 3); zona occludens protein 3; zonula o ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TJP3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TJP3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TJP3 |
Name | tight junction protein 3 |
Aliases | ZO-3; zona occludens 3; ZO3; tight junction protein 3 (zona occludens 3); zona occludens protein 3; zonula o ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TJP3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | TJP3 |
Name | tight junction protein 3 |
Aliases | ZO-3; zona occludens 3; ZO3; tight junction protein 3 (zona occludens 3); zona occludens protein 3; zonula o ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TJP3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | TJP3 |
Name | tight junction protein 3 |
Aliases | ZO-3; zona occludens 3; ZO3; tight junction protein 3 (zona occludens 3); zona occludens protein 3; zonula o ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TJP3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | TJP3 |
Name | tight junction protein 3 |
Aliases | ZO-3; zona occludens 3; ZO3; tight junction protein 3 (zona occludens 3); zona occludens protein 3; zonula o ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TJP3 collected from DrugBank database. |
There is no record. |