Summary | |
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Symbol | TKTL1 |
Name | transketolase-like 1 |
Aliases | TKR; TKT2; TK 2; transketolase-2; transketolase-related protein; Transketolase 2; Transketolase-like protein ...... |
Chromosomal Location | Xq28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Nucleus Note=Predominantly cytoplasmic and to a lesser extent also nuclear (PubMed:16969476). |
Domain |
PF02779 Transketolase PF02780 Transketolase PF00456 Transketolase |
Function |
Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. |
Biological Process |
GO:0005996 monosaccharide metabolic process GO:0006006 glucose metabolic process GO:0006007 glucose catabolic process GO:0006766 vitamin metabolic process GO:0006767 water-soluble vitamin metabolic process GO:0006772 thiamine metabolic process GO:0006790 sulfur compound metabolic process GO:0016052 carbohydrate catabolic process GO:0019318 hexose metabolic process GO:0019320 hexose catabolic process GO:0042723 thiamine-containing compound metabolic process GO:0044282 small molecule catabolic process GO:0044723 single-organism carbohydrate metabolic process GO:0044724 single-organism carbohydrate catabolic process GO:0046365 monosaccharide catabolic process GO:0072527 pyrimidine-containing compound metabolic process |
Molecular Function |
GO:0004802 transketolase activity GO:0016744 transferase activity, transferring aldehyde or ketonic groups |
Cellular Component | - |
KEGG |
hsa00030 Pentose phosphate pathway hsa01100 Metabolic pathways hsa01200 Carbon metabolism hsa01230 Biosynthesis of amino acids |
Reactome | - |
Summary | |
---|---|
Symbol | TKTL1 |
Name | transketolase-like 1 |
Aliases | TKR; TKT2; TK 2; transketolase-2; transketolase-related protein; Transketolase 2; Transketolase-like protein ...... |
Chromosomal Location | Xq28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TKTL1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TKTL1 |
Name | transketolase-like 1 |
Aliases | TKR; TKT2; TK 2; transketolase-2; transketolase-related protein; Transketolase 2; Transketolase-like protein ...... |
Chromosomal Location | Xq28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TKTL1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | TKTL1 |
Name | transketolase-like 1 |
Aliases | TKR; TKT2; TK 2; transketolase-2; transketolase-related protein; Transketolase 2; Transketolase-like protein ...... |
Chromosomal Location | Xq28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TKTL1 in various data sets.
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Points in the above scatter plot represent the mutation difference of TKTL1 in various data sets.
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Summary | |
---|---|
Symbol | TKTL1 |
Name | transketolase-like 1 |
Aliases | TKR; TKT2; TK 2; transketolase-2; transketolase-related protein; Transketolase 2; Transketolase-like protein ...... |
Chromosomal Location | Xq28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TKTL1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TKTL1 |
Name | transketolase-like 1 |
Aliases | TKR; TKT2; TK 2; transketolase-2; transketolase-related protein; Transketolase 2; Transketolase-like protein ...... |
Chromosomal Location | Xq28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TKTL1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TKTL1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | TKTL1 |
Name | transketolase-like 1 |
Aliases | TKR; TKT2; TK 2; transketolase-2; transketolase-related protein; Transketolase 2; Transketolase-like protein ...... |
Chromosomal Location | Xq28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TKTL1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TKTL1 |
Name | transketolase-like 1 |
Aliases | TKR; TKT2; TK 2; transketolase-2; transketolase-related protein; Transketolase 2; Transketolase-like protein ...... |
Chromosomal Location | Xq28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TKTL1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TKTL1 |
Name | transketolase-like 1 |
Aliases | TKR; TKT2; TK 2; transketolase-2; transketolase-related protein; Transketolase 2; Transketolase-like protein ...... |
Chromosomal Location | Xq28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TKTL1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TKTL1 |
Name | transketolase-like 1 |
Aliases | TKR; TKT2; TK 2; transketolase-2; transketolase-related protein; Transketolase 2; Transketolase-like protein ...... |
Chromosomal Location | Xq28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TKTL1 collected from DrugBank database. |
There is no record. |