Summary | |
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Symbol | TLR4 |
Name | toll-like receptor 4 |
Aliases | hToll; CD284; TLR-4; ARMD10; TOLL; homolog of Drosophila toll; CD antigen CD284 |
Chromosomal Location | 9q33.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type I membrane protein Early endosome Note=Upon complex formation with CD36 and TLR6, internalized through dynamin-dependent endocytosis (PubMed:20037584). Colocalizes with RFTN1 at cell membrane and then together with RFTN1 moves to endosomes, upon lipopolysaccharide stimulation. |
Domain |
PF13516 Leucine Rich repeat PF13855 Leucine rich repeat PF01582 TIR domain |
Function |
Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:27022195). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:9237759, PubMed:10835634, PubMed:27022195). Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+). Responses triggered by Ni(2+) require non-conserved histidines and are, therefore, species-specific (PubMed:20711192). Both M.tuberculosis HSP70 (dnaK) and HSP65 (groEL-2) act via this protein to stimulate NF-kappa-B expression (PubMed:15809303). In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (PubMed:23880187). Stimulation of monocytes in vitro with M.tuberculosis PstS1 induces p38 MAPK and ERK1/2 activation primarily via TLR2, but also partially via this receptor (PubMed:16622205). |
Biological Process |
GO:0000187 activation of MAPK activity GO:0001818 negative regulation of cytokine production GO:0001819 positive regulation of cytokine production GO:0001894 tissue homeostasis GO:0001933 negative regulation of protein phosphorylation GO:0002218 activation of innate immune response GO:0002221 pattern recognition receptor signaling pathway GO:0002224 toll-like receptor signaling pathway GO:0002237 response to molecule of bacterial origin GO:0002250 adaptive immune response GO:0002263 cell activation involved in immune response GO:0002274 myeloid leukocyte activation GO:0002285 lymphocyte activation involved in immune response GO:0002312 B cell activation involved in immune response GO:0002322 B cell proliferation involved in immune response GO:0002366 leukocyte activation involved in immune response GO:0002367 cytokine production involved in immune response GO:0002371 dendritic cell cytokine production GO:0002440 production of molecular mediator of immune response GO:0002443 leukocyte mediated immunity GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002521 leukocyte differentiation GO:0002532 production of molecular mediator involved in inflammatory response GO:0002537 nitric oxide production involved in inflammatory response GO:0002573 myeloid leukocyte differentiation GO:0002683 negative regulation of immune system process GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002697 regulation of immune effector process GO:0002699 positive regulation of immune effector process GO:0002700 regulation of production of molecular mediator of immune response GO:0002702 positive regulation of production of molecular mediator of immune response GO:0002703 regulation of leukocyte mediated immunity GO:0002718 regulation of cytokine production involved in immune response GO:0002720 positive regulation of cytokine production involved in immune response GO:0002730 regulation of dendritic cell cytokine production GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0002755 MyD88-dependent toll-like receptor signaling pathway GO:0002756 MyD88-independent toll-like receptor signaling pathway GO:0002757 immune response-activating signal transduction GO:0002758 innate immune response-activating signal transduction GO:0002761 regulation of myeloid leukocyte differentiation GO:0002762 negative regulation of myeloid leukocyte differentiation GO:0002764 immune response-regulating signaling pathway GO:0006606 protein import into nucleus GO:0006809 nitric oxide biosynthetic process GO:0006913 nucleocytoplasmic transport GO:0007249 I-kappaB kinase/NF-kappaB signaling GO:0007252 I-kappaB phosphorylation GO:0007254 JNK cascade GO:0007586 digestion GO:0007596 blood coagulation GO:0007599 hemostasis GO:0009306 protein secretion GO:0009595 detection of biotic stimulus GO:0009612 response to mechanical stimulus GO:0009620 response to fungus GO:0010001 glial cell differentiation GO:0010543 regulation of platelet activation GO:0010572 positive regulation of platelet activation GO:0010669 epithelial structure maintenance GO:0010934 macrophage cytokine production GO:0010935 regulation of macrophage cytokine production GO:0014002 astrocyte development GO:0016046 detection of fungus GO:0017038 protein import GO:0021782 glial cell development GO:0022600 digestive system process GO:0030099 myeloid cell differentiation GO:0030168 platelet activation GO:0030193 regulation of blood coagulation GO:0030194 positive regulation of blood coagulation GO:0030277 maintenance of gastrointestinal epithelium GO:0030316 osteoclast differentiation GO:0030522 intracellular receptor signaling pathway GO:0030888 regulation of B cell proliferation GO:0030890 positive regulation of B cell proliferation GO:0031098 stress-activated protein kinase signaling cascade GO:0031334 positive regulation of protein complex assembly GO:0031349 positive regulation of defense response GO:0031503 protein complex localization GO:0031663 lipopolysaccharide-mediated signaling pathway GO:0032103 positive regulation of response to external stimulus GO:0032147 activation of protein kinase activity GO:0032386 regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0032479 regulation of type I interferon production GO:0032481 positive regulation of type I interferon production GO:0032490 detection of molecule of bacterial origin GO:0032496 response to lipopolysaccharide GO:0032497 detection of lipopolysaccharide GO:0032602 chemokine production GO:0032606 type I interferon production GO:0032607 interferon-alpha production GO:0032608 interferon-beta production GO:0032609 interferon-gamma production GO:0032611 interleukin-1 beta production GO:0032612 interleukin-1 production GO:0032613 interleukin-10 production GO:0032615 interleukin-12 production GO:0032620 interleukin-17 production GO:0032627 interleukin-23 production GO:0032635 interleukin-6 production GO:0032637 interleukin-8 production GO:0032640 tumor necrosis factor production GO:0032642 regulation of chemokine production GO:0032647 regulation of interferon-alpha production GO:0032648 regulation of interferon-beta production GO:0032649 regulation of interferon-gamma production GO:0032652 regulation of interleukin-1 production GO:0032653 regulation of interleukin-10 production GO:0032655 regulation of interleukin-12 production GO:0032660 regulation of interleukin-17 production GO:0032667 regulation of interleukin-23 production GO:0032675 regulation of interleukin-6 production GO:0032677 regulation of interleukin-8 production GO:0032680 regulation of tumor necrosis factor production GO:0032689 negative regulation of interferon-gamma production GO:0032700 negative regulation of interleukin-17 production GO:0032707 negative regulation of interleukin-23 production GO:0032715 negative regulation of interleukin-6 production GO:0032720 negative regulation of tumor necrosis factor production GO:0032722 positive regulation of chemokine production GO:0032727 positive regulation of interferon-alpha production GO:0032728 positive regulation of interferon-beta production GO:0032729 positive regulation of interferon-gamma production GO:0032732 positive regulation of interleukin-1 production GO:0032733 positive regulation of interleukin-10 production GO:0032735 positive regulation of interleukin-12 production GO:0032755 positive regulation of interleukin-6 production GO:0032757 positive regulation of interleukin-8 production GO:0032760 positive regulation of tumor necrosis factor production GO:0032872 regulation of stress-activated MAPK cascade GO:0032874 positive regulation of stress-activated MAPK cascade GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0032946 positive regulation of mononuclear cell proliferation GO:0033157 regulation of intracellular protein transport GO:0033674 positive regulation of kinase activity GO:0034121 regulation of toll-like receptor signaling pathway GO:0034122 negative regulation of toll-like receptor signaling pathway GO:0034127 regulation of MyD88-independent toll-like receptor signaling pathway GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway GO:0034142 toll-like receptor 4 signaling pathway GO:0034504 protein localization to nucleus GO:0035666 TRIF-dependent toll-like receptor signaling pathway GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway GO:0042035 regulation of cytokine biosynthetic process GO:0042063 gliogenesis GO:0042088 T-helper 1 type immune response GO:0042089 cytokine biosynthetic process GO:0042090 interleukin-12 biosynthetic process GO:0042100 B cell proliferation GO:0042107 cytokine metabolic process GO:0042108 positive regulation of cytokine biosynthetic process GO:0042113 B cell activation GO:0042116 macrophage activation GO:0042228 interleukin-8 biosynthetic process GO:0042306 regulation of protein import into nucleus GO:0042307 positive regulation of protein import into nucleus GO:0042326 negative regulation of phosphorylation GO:0042345 regulation of NF-kappaB import into nucleus GO:0042346 positive regulation of NF-kappaB import into nucleus GO:0042348 NF-kappaB import into nucleus GO:0042533 tumor necrosis factor biosynthetic process GO:0042534 regulation of tumor necrosis factor biosynthetic process GO:0042535 positive regulation of tumor necrosis factor biosynthetic process GO:0042742 defense response to bacterium GO:0042990 regulation of transcription factor import into nucleus GO:0042991 transcription factor import into nucleus GO:0042993 positive regulation of transcription factor import into nucleus GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043254 regulation of protein complex assembly GO:0043405 regulation of MAP kinase activity GO:0043406 positive regulation of MAP kinase activity GO:0043409 negative regulation of MAPK cascade GO:0043410 positive regulation of MAPK cascade GO:0044089 positive regulation of cellular component biogenesis GO:0044546 NLRP3 inflammasome complex assembly GO:0044744 protein targeting to nucleus GO:0045075 regulation of interleukin-12 biosynthetic process GO:0045084 positive regulation of interleukin-12 biosynthetic process GO:0045088 regulation of innate immune response GO:0045089 positive regulation of innate immune response GO:0045342 MHC class II biosynthetic process GO:0045346 regulation of MHC class II biosynthetic process GO:0045348 positive regulation of MHC class II biosynthetic process GO:0045350 interferon-beta biosynthetic process GO:0045351 type I interferon biosynthetic process GO:0045357 regulation of interferon-beta biosynthetic process GO:0045359 positive regulation of interferon-beta biosynthetic process GO:0045414 regulation of interleukin-8 biosynthetic process GO:0045416 positive regulation of interleukin-8 biosynthetic process GO:0045428 regulation of nitric oxide biosynthetic process GO:0045429 positive regulation of nitric oxide biosynthetic process GO:0045637 regulation of myeloid cell differentiation GO:0045638 negative regulation of myeloid cell differentiation GO:0045670 regulation of osteoclast differentiation GO:0045671 negative regulation of osteoclast differentiation GO:0045860 positive regulation of protein kinase activity GO:0046209 nitric oxide metabolic process GO:0046328 regulation of JNK cascade GO:0046330 positive regulation of JNK cascade GO:0046651 lymphocyte proliferation GO:0046822 regulation of nucleocytoplasmic transport GO:0046824 positive regulation of nucleocytoplasmic transport GO:0048708 astrocyte differentiation GO:0048871 multicellular organismal homeostasis GO:0050663 cytokine secretion GO:0050670 regulation of lymphocyte proliferation GO:0050671 positive regulation of lymphocyte proliferation GO:0050701 interleukin-1 secretion GO:0050702 interleukin-1 beta secretion GO:0050707 regulation of cytokine secretion GO:0050708 regulation of protein secretion GO:0050727 regulation of inflammatory response GO:0050729 positive regulation of inflammatory response GO:0050817 coagulation GO:0050818 regulation of coagulation GO:0050820 positive regulation of coagulation GO:0050829 defense response to Gram-negative bacterium GO:0050864 regulation of B cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050871 positive regulation of B cell activation GO:0050878 regulation of body fluid levels GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051092 positive regulation of NF-kappaB transcription factor activity GO:0051169 nuclear transport GO:0051170 nuclear import GO:0051222 positive regulation of protein transport GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051403 stress-activated MAPK cascade GO:0051767 nitric-oxide synthase biosynthetic process GO:0051769 regulation of nitric-oxide synthase biosynthetic process GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process GO:0060249 anatomical structure homeostasis GO:0060729 intestinal epithelial structure maintenance GO:0060907 positive regulation of macrophage cytokine production GO:0061041 regulation of wound healing GO:0061081 positive regulation of myeloid leukocyte cytokine production involved in immune response GO:0061082 myeloid leukocyte cytokine production GO:0070265 necrotic cell death GO:0070266 necroptotic process GO:0070302 regulation of stress-activated protein kinase signaling cascade GO:0070304 positive regulation of stress-activated protein kinase signaling cascade GO:0070371 ERK1 and ERK2 cascade GO:0070372 regulation of ERK1 and ERK2 cascade GO:0070373 negative regulation of ERK1 and ERK2 cascade GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0070391 response to lipoteichoic acid GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway GO:0070426 positive regulation of nucleotide-binding oligomerization domain containing signaling pathway GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway GO:0070428 regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway GO:0070430 positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0070432 regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0070434 positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0070665 positive regulation of leukocyte proliferation GO:0071214 cellular response to abiotic stimulus GO:0071216 cellular response to biotic stimulus GO:0071219 cellular response to molecule of bacterial origin GO:0071222 cellular response to lipopolysaccharide GO:0071223 cellular response to lipoteichoic acid GO:0071260 cellular response to mechanical stimulus GO:0071396 cellular response to lipid GO:0071496 cellular response to external stimulus GO:0071706 tumor necrosis factor superfamily cytokine production GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:0072593 reactive oxygen species metabolic process GO:0090303 positive regulation of wound healing GO:0090316 positive regulation of intracellular protein transport GO:0097300 programmed necrotic cell death GO:0098542 defense response to other organism GO:0098543 detection of other organism GO:0098581 detection of external biotic stimulus GO:1900046 regulation of hemostasis GO:1900048 positive regulation of hemostasis GO:1900180 regulation of protein localization to nucleus GO:1900182 positive regulation of protein localization to nucleus GO:1900225 regulation of NLRP3 inflammasome complex assembly GO:1900227 positive regulation of NLRP3 inflammasome complex assembly GO:1902105 regulation of leukocyte differentiation GO:1902106 negative regulation of leukocyte differentiation GO:1902532 negative regulation of intracellular signal transduction GO:1902593 single-organism nuclear import GO:1903034 regulation of response to wounding GO:1903036 positive regulation of response to wounding GO:1903409 reactive oxygen species biosynthetic process GO:1903426 regulation of reactive oxygen species biosynthetic process GO:1903428 positive regulation of reactive oxygen species biosynthetic process GO:1903533 regulation of protein targeting GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production GO:1903706 regulation of hemopoiesis GO:1903707 negative regulation of hemopoiesis GO:1903829 positive regulation of cellular protein localization GO:1904407 positive regulation of nitric oxide metabolic process GO:1904589 regulation of protein import GO:1904591 positive regulation of protein import GO:1904951 positive regulation of establishment of protein localization GO:2000377 regulation of reactive oxygen species metabolic process GO:2000379 positive regulation of reactive oxygen species metabolic process GO:2001057 reactive nitrogen species metabolic process |
Molecular Function |
GO:0001530 lipopolysaccharide binding GO:0001875 lipopolysaccharide receptor activity GO:0008329 signaling pattern recognition receptor activity GO:0038187 pattern recognition receptor activity |
Cellular Component |
GO:0009897 external side of plasma membrane GO:0010008 endosome membrane GO:0043235 receptor complex GO:0044440 endosomal part GO:0046696 lipopolysaccharide receptor complex GO:0098552 side of membrane |
KEGG |
hsa04064 NF-kappa B signaling pathway hsa04066 HIF-1 signaling pathway hsa04145 Phagosome hsa04151 PI3K-Akt signaling pathway hsa04620 Toll-like receptor signaling pathway hsa04621 NOD-like receptor signaling pathway |
Reactome |
R-HSA-166054: Activated TLR4 signalling R-HSA-936964: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-HSA-1280218: Adaptive Immune System R-HSA-1236975: Antigen processing-Cross presentation R-HSA-109581: Apoptosis R-HSA-5357769: Caspase activation via extrinsic apoptotic signalling pathway R-HSA-983169: Class I MHC mediated antigen processing & presentation R-HSA-1643685: Disease R-HSA-5602358: Diseases associated with the TLR signaling cascade R-HSA-5260271: Diseases of Immune System R-HSA-1236974: ER-Phagosome pathway R-HSA-937041: IKK complex recruitment mediated by RIP1 R-HSA-975163: IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-5603041: IRAK4 deficiency (TLR2/4) R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-140534: Ligand-dependent caspase activation R-HSA-5602498: MyD88 deficiency (TLR2/4) R-HSA-975155: MyD88 dependent cascade initiated on endosome R-HSA-166166: MyD88-independent TLR3/TLR4 cascade R-HSA-166058: MyD88 R-HSA-5357801: Programmed Cell Death R-HSA-5686938: Regulation of TLR by endogenous ligand R-HSA-168180: TRAF6 Mediated Induction of proinflammatory cytokines R-HSA-975138: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-937072: TRAF6 mediated induction of TAK1 complex R-HSA-937061: TRIF-mediated TLR3/TLR4 signaling R-HSA-2562578: TRIF-mediated programmed cell death R-HSA-181438: Toll Like Receptor 2 (TLR2) Cascade R-HSA-168164: Toll Like Receptor 3 (TLR3) Cascade R-HSA-166016: Toll Like Receptor 4 (TLR4) Cascade R-HSA-168181: Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168138: Toll Like Receptor 9 (TLR9) Cascade R-HSA-168179: Toll Like Receptor TLR1 R-HSA-168188: Toll Like Receptor TLR6 R-HSA-168898: Toll-Like Receptors Cascades |
Summary | |
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Symbol | TLR4 |
Name | toll-like receptor 4 |
Aliases | hToll; CD284; TLR-4; ARMD10; TOLL; homolog of Drosophila toll; CD antigen CD284 |
Chromosomal Location | 9q33.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TLR4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between TLR4 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | TLR4 |
Name | toll-like receptor 4 |
Aliases | hToll; CD284; TLR-4; ARMD10; TOLL; homolog of Drosophila toll; CD antigen CD284 |
Chromosomal Location | 9q33.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TLR4 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TLR4 |
Name | toll-like receptor 4 |
Aliases | hToll; CD284; TLR-4; ARMD10; TOLL; homolog of Drosophila toll; CD antigen CD284 |
Chromosomal Location | 9q33.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TLR4 in various data sets.
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Points in the above scatter plot represent the mutation difference of TLR4 in various data sets.
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Summary | |
---|---|
Symbol | TLR4 |
Name | toll-like receptor 4 |
Aliases | hToll; CD284; TLR-4; ARMD10; TOLL; homolog of Drosophila toll; CD antigen CD284 |
Chromosomal Location | 9q33.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TLR4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | TLR4 |
Name | toll-like receptor 4 |
Aliases | hToll; CD284; TLR-4; ARMD10; TOLL; homolog of Drosophila toll; CD antigen CD284 |
Chromosomal Location | 9q33.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TLR4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TLR4. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TLR4 |
Name | toll-like receptor 4 |
Aliases | hToll; CD284; TLR-4; ARMD10; TOLL; homolog of Drosophila toll; CD antigen CD284 |
Chromosomal Location | 9q33.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TLR4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TLR4 |
Name | toll-like receptor 4 |
Aliases | hToll; CD284; TLR-4; ARMD10; TOLL; homolog of Drosophila toll; CD antigen CD284 |
Chromosomal Location | 9q33.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TLR4 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TLR4 |
Name | toll-like receptor 4 |
Aliases | hToll; CD284; TLR-4; ARMD10; TOLL; homolog of Drosophila toll; CD antigen CD284 |
Chromosomal Location | 9q33.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TLR4 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | TLR4 |
Name | toll-like receptor 4 |
Aliases | hToll; CD284; TLR-4; ARMD10; TOLL; homolog of Drosophila toll; CD antigen CD284 |
Chromosomal Location | 9q33.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TLR4 collected from DrugBank database. |
Details on drugs targeting TLR4.
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