Summary | |
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Symbol | TLR7 |
Name | toll-like receptor 7 |
Aliases | TLR7-like; toll-like receptor 7-like |
Chromosomal Location | Xp22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Endoplasmic reticulum membrane Single-pass type I membrane protein Endosome Lysosome Cytoplasmic vesicle, phagosome Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. |
Domain |
PF13306 Leucine rich repeats (6 copies) PF13855 Leucine rich repeat PF01582 TIR domain |
Function |
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). |
Biological Process |
GO:0001774 microglial cell activation GO:0001819 positive regulation of cytokine production GO:0002218 activation of innate immune response GO:0002221 pattern recognition receptor signaling pathway GO:0002224 toll-like receptor signaling pathway GO:0002274 myeloid leukocyte activation GO:0002755 MyD88-dependent toll-like receptor signaling pathway GO:0002757 immune response-activating signal transduction GO:0002758 innate immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0006606 protein import into nucleus GO:0006913 nucleocytoplasmic transport GO:0007249 I-kappaB kinase/NF-kappaB signaling GO:0007252 I-kappaB phosphorylation GO:0009612 response to mechanical stimulus GO:0009615 response to virus GO:0017038 protein import GO:0031349 positive regulation of defense response GO:0031503 protein complex localization GO:0032103 positive regulation of response to external stimulus GO:0032386 regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0032479 regulation of type I interferon production GO:0032481 positive regulation of type I interferon production GO:0032602 chemokine production GO:0032606 type I interferon production GO:0032607 interferon-alpha production GO:0032608 interferon-beta production GO:0032609 interferon-gamma production GO:0032635 interleukin-6 production GO:0032637 interleukin-8 production GO:0032642 regulation of chemokine production GO:0032647 regulation of interferon-alpha production GO:0032648 regulation of interferon-beta production GO:0032649 regulation of interferon-gamma production GO:0032675 regulation of interleukin-6 production GO:0032677 regulation of interleukin-8 production GO:0032722 positive regulation of chemokine production GO:0032727 positive regulation of interferon-alpha production GO:0032728 positive regulation of interferon-beta production GO:0032729 positive regulation of interferon-gamma production GO:0032755 positive regulation of interleukin-6 production GO:0032757 positive regulation of interleukin-8 production GO:0033157 regulation of intracellular protein transport GO:0034154 toll-like receptor 7 signaling pathway GO:0034162 toll-like receptor 9 signaling pathway GO:0034504 protein localization to nucleus GO:0042035 regulation of cytokine biosynthetic process GO:0042089 cytokine biosynthetic process GO:0042095 interferon-gamma biosynthetic process GO:0042107 cytokine metabolic process GO:0042108 positive regulation of cytokine biosynthetic process GO:0042116 macrophage activation GO:0042228 interleukin-8 biosynthetic process GO:0042306 regulation of protein import into nucleus GO:0042307 positive regulation of protein import into nucleus GO:0042345 regulation of NF-kappaB import into nucleus GO:0042346 positive regulation of NF-kappaB import into nucleus GO:0042348 NF-kappaB import into nucleus GO:0042990 regulation of transcription factor import into nucleus GO:0042991 transcription factor import into nucleus GO:0042993 positive regulation of transcription factor import into nucleus GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0044744 protein targeting to nucleus GO:0045072 regulation of interferon-gamma biosynthetic process GO:0045078 positive regulation of interferon-gamma biosynthetic process GO:0045088 regulation of innate immune response GO:0045089 positive regulation of innate immune response GO:0045349 interferon-alpha biosynthetic process GO:0045350 interferon-beta biosynthetic process GO:0045351 type I interferon biosynthetic process GO:0045354 regulation of interferon-alpha biosynthetic process GO:0045356 positive regulation of interferon-alpha biosynthetic process GO:0045357 regulation of interferon-beta biosynthetic process GO:0045359 positive regulation of interferon-beta biosynthetic process GO:0045414 regulation of interleukin-8 biosynthetic process GO:0045416 positive regulation of interleukin-8 biosynthetic process GO:0046822 regulation of nucleocytoplasmic transport GO:0046824 positive regulation of nucleocytoplasmic transport GO:0050727 regulation of inflammatory response GO:0050729 positive regulation of inflammatory response GO:0051169 nuclear transport GO:0051170 nuclear import GO:0051222 positive regulation of protein transport GO:0051607 defense response to virus GO:0071214 cellular response to abiotic stimulus GO:0071260 cellular response to mechanical stimulus GO:0071496 cellular response to external stimulus GO:0090316 positive regulation of intracellular protein transport GO:0098542 defense response to other organism GO:1900180 regulation of protein localization to nucleus GO:1900182 positive regulation of protein localization to nucleus GO:1902593 single-organism nuclear import GO:1903533 regulation of protein targeting GO:1903829 positive regulation of cellular protein localization GO:1904589 regulation of protein import GO:1904591 positive regulation of protein import GO:1904951 positive regulation of establishment of protein localization |
Molecular Function |
GO:0003725 double-stranded RNA binding GO:0003727 single-stranded RNA binding GO:0008144 drug binding GO:0035197 siRNA binding |
Cellular Component |
GO:0005765 lysosomal membrane GO:0010008 endosome membrane GO:0030139 endocytic vesicle GO:0032009 early phagosome GO:0036019 endolysosome GO:0036020 endolysosome membrane GO:0043235 receptor complex GO:0044440 endosomal part GO:0045335 phagocytic vesicle GO:0098852 lytic vacuole membrane |
KEGG |
hsa04620 Toll-like receptor signaling pathway |
Reactome |
R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-975155: MyD88 dependent cascade initiated on endosome R-HSA-975110: TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975138: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-168181: Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168138: Toll Like Receptor 9 (TLR9) Cascade R-HSA-168898: Toll-Like Receptors Cascades R-HSA-1679131: Trafficking and processing of endosomal TLR |
Summary | |
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Symbol | TLR7 |
Name | toll-like receptor 7 |
Aliases | TLR7-like; toll-like receptor 7-like |
Chromosomal Location | Xp22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TLR7 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between TLR7 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | TLR7 |
Name | toll-like receptor 7 |
Aliases | TLR7-like; toll-like receptor 7-like |
Chromosomal Location | Xp22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TLR7 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TLR7 |
Name | toll-like receptor 7 |
Aliases | TLR7-like; toll-like receptor 7-like |
Chromosomal Location | Xp22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TLR7 in various data sets.
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Points in the above scatter plot represent the mutation difference of TLR7 in various data sets.
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Summary | |
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Symbol | TLR7 |
Name | toll-like receptor 7 |
Aliases | TLR7-like; toll-like receptor 7-like |
Chromosomal Location | Xp22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TLR7. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | TLR7 |
Name | toll-like receptor 7 |
Aliases | TLR7-like; toll-like receptor 7-like |
Chromosomal Location | Xp22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TLR7. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TLR7. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TLR7 |
Name | toll-like receptor 7 |
Aliases | TLR7-like; toll-like receptor 7-like |
Chromosomal Location | Xp22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TLR7. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | TLR7 |
Name | toll-like receptor 7 |
Aliases | TLR7-like; toll-like receptor 7-like |
Chromosomal Location | Xp22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TLR7 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TLR7 |
Name | toll-like receptor 7 |
Aliases | TLR7-like; toll-like receptor 7-like |
Chromosomal Location | Xp22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TLR7 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TLR7 |
Name | toll-like receptor 7 |
Aliases | TLR7-like; toll-like receptor 7-like |
Chromosomal Location | Xp22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TLR7 collected from DrugBank database. |
Details on drugs targeting TLR7.
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