Summary | |
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Symbol | TLR9 |
Name | toll-like receptor 9 |
Aliases | CD289; CD antigen CD289 |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Endoplasmic reticulum membrane Single-pass type I membrane protein Endosome Lysosome Cytoplasmic vesicle, phagosome Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. Exit from the ER requires UNC93B1. Endolysosomal localization is required for proteolytic cleavage and subsequent activation. Intracellular localization of the active receptor may prevent from responding to self nucleic acid. |
Domain |
PF13516 Leucine Rich repeat PF13855 Leucine rich repeat PF01582 TIR domain |
Function |
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:11564765, PubMed:17932028). Controls lymphocyte response to Helicobacter infection (By similarity). Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (PubMed:23857366). |
Biological Process |
GO:0001818 negative regulation of cytokine production GO:0001819 positive regulation of cytokine production GO:0001894 tissue homeostasis GO:0002218 activation of innate immune response GO:0002221 pattern recognition receptor signaling pathway GO:0002224 toll-like receptor signaling pathway GO:0002237 response to molecule of bacterial origin GO:0002683 negative regulation of immune system process GO:0002755 MyD88-dependent toll-like receptor signaling pathway GO:0002757 immune response-activating signal transduction GO:0002758 innate immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0006606 protein import into nucleus GO:0006644 phospholipid metabolic process GO:0006650 glycerophospholipid metabolic process GO:0006661 phosphatidylinositol biosynthetic process GO:0006816 calcium ion transport GO:0006913 nucleocytoplasmic transport GO:0007249 I-kappaB kinase/NF-kappaB signaling GO:0007252 I-kappaB phosphorylation GO:0007254 JNK cascade GO:0007586 digestion GO:0008654 phospholipid biosynthetic process GO:0009306 protein secretion GO:0010669 epithelial structure maintenance GO:0010959 regulation of metal ion transport GO:0017038 protein import GO:0022600 digestive system process GO:0022898 regulation of transmembrane transporter activity GO:0030277 maintenance of gastrointestinal epithelium GO:0031098 stress-activated protein kinase signaling cascade GO:0031349 positive regulation of defense response GO:0031503 protein complex localization GO:0032088 negative regulation of NF-kappaB transcription factor activity GO:0032103 positive regulation of response to external stimulus GO:0032386 regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0032409 regulation of transporter activity GO:0032410 negative regulation of transporter activity GO:0032412 regulation of ion transmembrane transporter activity GO:0032413 negative regulation of ion transmembrane transporter activity GO:0032479 regulation of type I interferon production GO:0032481 positive regulation of type I interferon production GO:0032602 chemokine production GO:0032604 granulocyte macrophage colony-stimulating factor production GO:0032606 type I interferon production GO:0032607 interferon-alpha production GO:0032608 interferon-beta production GO:0032609 interferon-gamma production GO:0032613 interleukin-10 production GO:0032615 interleukin-12 production GO:0032621 interleukin-18 production GO:0032635 interleukin-6 production GO:0032637 interleukin-8 production GO:0032640 tumor necrosis factor production GO:0032642 regulation of chemokine production GO:0032645 regulation of granulocyte macrophage colony-stimulating factor production GO:0032647 regulation of interferon-alpha production GO:0032648 regulation of interferon-beta production GO:0032649 regulation of interferon-gamma production GO:0032653 regulation of interleukin-10 production GO:0032655 regulation of interleukin-12 production GO:0032661 regulation of interleukin-18 production GO:0032675 regulation of interleukin-6 production GO:0032677 regulation of interleukin-8 production GO:0032680 regulation of tumor necrosis factor production GO:0032715 negative regulation of interleukin-6 production GO:0032717 negative regulation of interleukin-8 production GO:0032722 positive regulation of chemokine production GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032727 positive regulation of interferon-alpha production GO:0032728 positive regulation of interferon-beta production GO:0032729 positive regulation of interferon-gamma production GO:0032733 positive regulation of interleukin-10 production GO:0032735 positive regulation of interleukin-12 production GO:0032741 positive regulation of interleukin-18 production GO:0032755 positive regulation of interleukin-6 production GO:0032757 positive regulation of interleukin-8 production GO:0032760 positive regulation of tumor necrosis factor production GO:0032780 negative regulation of ATPase activity GO:0032872 regulation of stress-activated MAPK cascade GO:0032874 positive regulation of stress-activated MAPK cascade GO:0033157 regulation of intracellular protein transport GO:0033674 positive regulation of kinase activity GO:0034121 regulation of toll-like receptor signaling pathway GO:0034122 negative regulation of toll-like receptor signaling pathway GO:0034123 positive regulation of toll-like receptor signaling pathway GO:0034162 toll-like receptor 9 signaling pathway GO:0034504 protein localization to nucleus GO:0034762 regulation of transmembrane transport GO:0034763 negative regulation of transmembrane transport GO:0034765 regulation of ion transmembrane transport GO:0034766 negative regulation of ion transmembrane transport GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process GO:0042035 regulation of cytokine biosynthetic process GO:0042089 cytokine biosynthetic process GO:0042095 interferon-gamma biosynthetic process GO:0042107 cytokine metabolic process GO:0042108 positive regulation of cytokine biosynthetic process GO:0042306 regulation of protein import into nucleus GO:0042307 positive regulation of protein import into nucleus GO:0042345 regulation of NF-kappaB import into nucleus GO:0042346 positive regulation of NF-kappaB import into nucleus GO:0042348 NF-kappaB import into nucleus GO:0042742 defense response to bacterium GO:0042990 regulation of transcription factor import into nucleus GO:0042991 transcription factor import into nucleus GO:0042993 positive regulation of transcription factor import into nucleus GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043271 negative regulation of ion transport GO:0043405 regulation of MAP kinase activity GO:0043406 positive regulation of MAP kinase activity GO:0043410 positive regulation of MAPK cascade GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity GO:0043462 regulation of ATPase activity GO:0043506 regulation of JUN kinase activity GO:0043507 positive regulation of JUN kinase activity GO:0044744 protein targeting to nucleus GO:0045017 glycerolipid biosynthetic process GO:0045072 regulation of interferon-gamma biosynthetic process GO:0045078 positive regulation of interferon-gamma biosynthetic process GO:0045088 regulation of innate immune response GO:0045089 positive regulation of innate immune response GO:0045349 interferon-alpha biosynthetic process GO:0045350 interferon-beta biosynthetic process GO:0045351 type I interferon biosynthetic process GO:0045354 regulation of interferon-alpha biosynthetic process GO:0045356 positive regulation of interferon-alpha biosynthetic process GO:0045357 regulation of interferon-beta biosynthetic process GO:0045359 positive regulation of interferon-beta biosynthetic process GO:0045860 positive regulation of protein kinase activity GO:0046328 regulation of JNK cascade GO:0046330 positive regulation of JNK cascade GO:0046474 glycerophospholipid biosynthetic process GO:0046486 glycerolipid metabolic process GO:0046488 phosphatidylinositol metabolic process GO:0046822 regulation of nucleocytoplasmic transport GO:0046824 positive regulation of nucleocytoplasmic transport GO:0048871 multicellular organismal homeostasis GO:0050663 cytokine secretion GO:0050707 regulation of cytokine secretion GO:0050708 regulation of protein secretion GO:0050727 regulation of inflammatory response GO:0050729 positive regulation of inflammatory response GO:0050829 defense response to Gram-negative bacterium GO:0051051 negative regulation of transport GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051092 positive regulation of NF-kappaB transcription factor activity GO:0051169 nuclear transport GO:0051170 nuclear import GO:0051222 positive regulation of protein transport GO:0051346 negative regulation of hydrolase activity GO:0051403 stress-activated MAPK cascade GO:0051767 nitric-oxide synthase biosynthetic process GO:0051769 regulation of nitric-oxide synthase biosynthetic process GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process GO:0051924 regulation of calcium ion transport GO:0051926 negative regulation of calcium ion transport GO:0060249 anatomical structure homeostasis GO:0070302 regulation of stress-activated protein kinase signaling cascade GO:0070304 positive regulation of stress-activated protein kinase signaling cascade GO:0070588 calcium ion transmembrane transport GO:0070838 divalent metal ion transport GO:0071706 tumor necrosis factor superfamily cytokine production GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:0072511 divalent inorganic cation transport GO:0090316 positive regulation of intracellular protein transport GO:0098542 defense response to other organism GO:1900180 regulation of protein localization to nucleus GO:1900182 positive regulation of protein localization to nucleus GO:1901019 regulation of calcium ion transmembrane transporter activity GO:1901020 negative regulation of calcium ion transmembrane transporter activity GO:1901894 regulation of calcium-transporting ATPase activity GO:1901895 negative regulation of calcium-transporting ATPase activity GO:1902593 single-organism nuclear import GO:1903169 regulation of calcium ion transmembrane transport GO:1903170 negative regulation of calcium ion transmembrane transport GO:1903533 regulation of protein targeting GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production GO:1903829 positive regulation of cellular protein localization GO:1904062 regulation of cation transmembrane transport GO:1904063 negative regulation of cation transmembrane transport GO:1904589 regulation of protein import GO:1904591 positive regulation of protein import GO:1904951 positive regulation of establishment of protein localization |
Molecular Function |
GO:0005126 cytokine receptor binding GO:0005149 interleukin-1 receptor binding GO:0016303 1-phosphatidylinositol-3-kinase activity GO:0035004 phosphatidylinositol 3-kinase activity GO:0035197 siRNA binding GO:0052742 phosphatidylinositol kinase activity GO:0070851 growth factor receptor binding |
Cellular Component |
GO:0005765 lysosomal membrane GO:0010008 endosome membrane GO:0016323 basolateral plasma membrane GO:0016324 apical plasma membrane GO:0030139 endocytic vesicle GO:0032009 early phagosome GO:0036019 endolysosome GO:0036020 endolysosome membrane GO:0044440 endosomal part GO:0045177 apical part of cell GO:0045335 phagocytic vesicle GO:0098852 lytic vacuole membrane |
KEGG |
hsa04620 Toll-like receptor signaling pathway |
Reactome |
R-HSA-2428924: IGF1R signaling cascade R-HSA-112399: IRS-mediated signalling R-HSA-2428928: IRS-related events triggered by IGF1R R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-74751: Insulin receptor signalling cascade R-HSA-975155: MyD88 dependent cascade initiated on endosome R-HSA-109704: PI3K Cascade R-HSA-162582: Signal Transduction R-HSA-74752: Signaling by Insulin receptor R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-975110: TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975138: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-168181: Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168138: Toll Like Receptor 9 (TLR9) Cascade R-HSA-168898: Toll-Like Receptors Cascades R-HSA-1679131: Trafficking and processing of endosomal TLR |
Summary | |
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Symbol | TLR9 |
Name | toll-like receptor 9 |
Aliases | CD289; CD antigen CD289 |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TLR9 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between TLR9 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | TLR9 |
Name | toll-like receptor 9 |
Aliases | CD289; CD antigen CD289 |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TLR9 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TLR9 |
Name | toll-like receptor 9 |
Aliases | CD289; CD antigen CD289 |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TLR9 in various data sets.
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Points in the above scatter plot represent the mutation difference of TLR9 in various data sets.
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Summary | |
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Symbol | TLR9 |
Name | toll-like receptor 9 |
Aliases | CD289; CD antigen CD289 |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TLR9. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | TLR9 |
Name | toll-like receptor 9 |
Aliases | CD289; CD antigen CD289 |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TLR9. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TLR9. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TLR9 |
Name | toll-like receptor 9 |
Aliases | CD289; CD antigen CD289 |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TLR9. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | TLR9 |
Name | toll-like receptor 9 |
Aliases | CD289; CD antigen CD289 |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TLR9 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | TLR9 |
Name | toll-like receptor 9 |
Aliases | CD289; CD antigen CD289 |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TLR9 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | TLR9 |
Name | toll-like receptor 9 |
Aliases | CD289; CD antigen CD289 |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TLR9 collected from DrugBank database. |
Details on drugs targeting TLR9.
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