Summary | |
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Symbol | TMCO6 |
Name | transmembrane and coiled-coil domains 6 |
Aliases | FLJ39769; PRO1580; Transmembrane and coiled-coil domain-containing protein 6 |
Chromosomal Location | 5q31.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Multi-pass membrane protein |
Domain | - |
Function |
- |
Biological Process |
GO:0006606 protein import into nucleus GO:0006913 nucleocytoplasmic transport GO:0017038 protein import GO:0034504 protein localization to nucleus GO:0044744 protein targeting to nucleus GO:0051169 nuclear transport GO:0051170 nuclear import GO:1902593 single-organism nuclear import |
Molecular Function |
GO:0008565 protein transporter activity |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | TMCO6 |
Name | transmembrane and coiled-coil domains 6 |
Aliases | FLJ39769; PRO1580; Transmembrane and coiled-coil domain-containing protein 6 |
Chromosomal Location | 5q31.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TMCO6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TMCO6 |
Name | transmembrane and coiled-coil domains 6 |
Aliases | FLJ39769; PRO1580; Transmembrane and coiled-coil domain-containing protein 6 |
Chromosomal Location | 5q31.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TMCO6 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | TMCO6 |
Name | transmembrane and coiled-coil domains 6 |
Aliases | FLJ39769; PRO1580; Transmembrane and coiled-coil domain-containing protein 6 |
Chromosomal Location | 5q31.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TMCO6 in various data sets.
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Points in the above scatter plot represent the mutation difference of TMCO6 in various data sets.
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Summary | |
---|---|
Symbol | TMCO6 |
Name | transmembrane and coiled-coil domains 6 |
Aliases | FLJ39769; PRO1580; Transmembrane and coiled-coil domain-containing protein 6 |
Chromosomal Location | 5q31.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TMCO6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TMCO6 |
Name | transmembrane and coiled-coil domains 6 |
Aliases | FLJ39769; PRO1580; Transmembrane and coiled-coil domain-containing protein 6 |
Chromosomal Location | 5q31.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TMCO6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TMCO6. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TMCO6 |
Name | transmembrane and coiled-coil domains 6 |
Aliases | FLJ39769; PRO1580; Transmembrane and coiled-coil domain-containing protein 6 |
Chromosomal Location | 5q31.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TMCO6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TMCO6 |
Name | transmembrane and coiled-coil domains 6 |
Aliases | FLJ39769; PRO1580; Transmembrane and coiled-coil domain-containing protein 6 |
Chromosomal Location | 5q31.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TMCO6 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TMCO6 |
Name | transmembrane and coiled-coil domains 6 |
Aliases | FLJ39769; PRO1580; Transmembrane and coiled-coil domain-containing protein 6 |
Chromosomal Location | 5q31.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TMCO6 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TMCO6 |
Name | transmembrane and coiled-coil domains 6 |
Aliases | FLJ39769; PRO1580; Transmembrane and coiled-coil domain-containing protein 6 |
Chromosomal Location | 5q31.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TMCO6 collected from DrugBank database. |
There is no record. |