Browse TMED10

Summary
SymbolTMED10
Nametransmembrane p24 trafficking protein 10
Aliases TMP21; P24(DELTA); p24d1; p24delta1; transmembrane emp24-like trafficking protein 10 (yeast); S31I125; S31II ......
Chromosomal Location14q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Melanosome. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle membrane Single-pass type I membrane protein Cell membrane Golgi apparatus, trans-Golgi network membrane Single-pass type I membrane protein Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Cycles between compartments of the early secretatory pathway.
Domain PF01105 emp24/gp25L/p24 family/GOLD
Function

Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1 (By similarity). In COPI vesicle-mediated retrograde transport involved in the biogenesis of COPI vesicles and vesicle coat recruitment. On Golgi membranes, acts as primary receptor for ARF1-GDP which is involved in COPI-vesicle formation. Increases coatomer-dependent GTPase-activating activity of ARFGAP2. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2LR1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Involved in trafficking of amyloid beta A4 protein and soluble APP-beta release (independent of modulation of gamma-secretase activity). As part of the presenilin-dependent gamma-secretase complex regulates gamma-cleavages of the amyloid beta A4 protein to yield amyloid-beta 40 (Abeta40). Involved in organization of the Golgi apparatus.

> Gene Ontology
 
Biological Process GO:0001655 urogenital system development
GO:0001822 kidney development
GO:0006887 exocytosis
GO:0006888 ER to Golgi vesicle-mediated transport
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER
GO:0006900 membrane budding
GO:0006901 vesicle coating
GO:0006903 vesicle targeting
GO:0007030 Golgi organization
GO:0016050 vesicle organization
GO:0034205 beta-amyloid formation
GO:0034248 regulation of cellular amide metabolic process
GO:0035459 cargo loading into vesicle
GO:0035964 COPI-coated vesicle budding
GO:0042982 amyloid precursor protein metabolic process
GO:0042987 amyloid precursor protein catabolic process
GO:0043279 response to alkaloid
GO:0045055 regulated exocytosis
GO:0048193 Golgi vesicle transport
GO:0048194 Golgi vesicle budding
GO:0048199 vesicle targeting, to, from or within Golgi
GO:0048200 Golgi transport vesicle coating
GO:0048205 COPI coating of Golgi vesicle
GO:0048207 vesicle targeting, rough ER to cis-Golgi
GO:0048208 COPII vesicle coating
GO:0050435 beta-amyloid metabolic process
GO:0051259 protein oligomerization
GO:0051640 organelle localization
GO:0051648 vesicle localization
GO:0051650 establishment of vesicle localization
GO:0051656 establishment of organelle localization
GO:0072001 renal system development
GO:0090114 COPII-coated vesicle budding
GO:1902003 regulation of beta-amyloid formation
GO:1902991 regulation of amyloid precursor protein catabolic process
Molecular Function GO:0000149 SNARE binding
GO:0019905 syntaxin binding
Cellular Component GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005798 Golgi-associated vesicle
GO:0005801 cis-Golgi network
GO:0012507 ER to Golgi transport vesicle membrane
GO:0030133 transport vesicle
GO:0030134 ER to Golgi transport vesicle
GO:0030135 coated vesicle
GO:0030136 clathrin-coated vesicle
GO:0030137 COPI-coated vesicle
GO:0030140 trans-Golgi network transport vesicle
GO:0030141 secretory granule
GO:0030658 transport vesicle membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0030662 coated vesicle membrane
GO:0030667 secretory granule membrane
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0042470 melanosome
GO:0042588 zymogen granule
GO:0042589 zymogen granule membrane
GO:0048770 pigment granule
GO:0070765 gamma-secretase complex
GO:0099503 secretory vesicle
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-446203: Asparagine N-linked glycosylation
R-HSA-6811434: COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-6807878: COPI-mediated anterograde transport
R-HSA-204005: COPII (Coat Protein 2) Mediated Vesicle Transport
R-HSA-5694530: Cargo concentration in the ER
R-HSA-199977: ER to Golgi Anterograde Transport
R-HSA-8856688: Golgi-to-ER retrograde transport
R-HSA-6811442: Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-199991: Membrane Trafficking
R-HSA-392499: Metabolism of proteins
R-HSA-597592: Post-translational protein modification
R-HSA-948021: Transport to the Golgi and subsequent modification
R-HSA-5653656: Vesicle-mediated transport
Summary
SymbolTMED10
Nametransmembrane p24 trafficking protein 10
Aliases TMP21; P24(DELTA); p24d1; p24delta1; transmembrane emp24-like trafficking protein 10 (yeast); S31I125; S31II ......
Chromosomal Location14q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between TMED10 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolTMED10
Nametransmembrane p24 trafficking protein 10
Aliases TMP21; P24(DELTA); p24d1; p24delta1; transmembrane emp24-like trafficking protein 10 (yeast); S31I125; S31II ......
Chromosomal Location14q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of TMED10 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell logFC: -2.58; FDR: 0.02150 Resistant to T cell-mediated killing
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolTMED10
Nametransmembrane p24 trafficking protein 10
Aliases TMP21; P24(DELTA); p24d1; p24delta1; transmembrane emp24-like trafficking protein 10 (yeast); S31I125; S31II ......
Chromosomal Location14q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of TMED10 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.350.217
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.5550.862
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.2030.929
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2360.546
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.0710.974
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.4490.878
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.220.675
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.3170.899
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.1460.959
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.2060.926
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.3190.926
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0090.885
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of TMED10 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolTMED10
Nametransmembrane p24 trafficking protein 10
Aliases TMP21; P24(DELTA); p24d1; p24delta1; transmembrane emp24-like trafficking protein 10 (yeast); S31I125; S31II ......
Chromosomal Location14q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TMED10. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolTMED10
Nametransmembrane p24 trafficking protein 10
Aliases TMP21; P24(DELTA); p24d1; p24delta1; transmembrane emp24-like trafficking protein 10 (yeast); S31I125; S31II ......
Chromosomal Location14q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TMED10. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TMED10.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolTMED10
Nametransmembrane p24 trafficking protein 10
Aliases TMP21; P24(DELTA); p24d1; p24delta1; transmembrane emp24-like trafficking protein 10 (yeast); S31I125; S31II ......
Chromosomal Location14q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TMED10. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolTMED10
Nametransmembrane p24 trafficking protein 10
Aliases TMP21; P24(DELTA); p24d1; p24delta1; transmembrane emp24-like trafficking protein 10 (yeast); S31I125; S31II ......
Chromosomal Location14q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of TMED10 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolTMED10
Nametransmembrane p24 trafficking protein 10
Aliases TMP21; P24(DELTA); p24d1; p24delta1; transmembrane emp24-like trafficking protein 10 (yeast); S31I125; S31II ......
Chromosomal Location14q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between TMED10 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolTMED10
Nametransmembrane p24 trafficking protein 10
Aliases TMP21; P24(DELTA); p24d1; p24delta1; transmembrane emp24-like trafficking protein 10 (yeast); S31I125; S31II ......
Chromosomal Location14q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting TMED10 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.