Summary | |
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Symbol | TMED2 |
Name | transmembrane p24 trafficking protein 2 |
Aliases | RNP24; P24A; p24beta1; p24b1; transmembrane emp24 domain trafficking protein 2; coated vesicle membrane prot ...... |
Chromosomal Location | 12q24.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasmic vesicle membrane Single-pass type I membrane protein Cytoplasmic vesicle, COPI-coated vesicle membrane Single-pass type I membrane protein Golgi apparatus, cis-Golgi network membrane Single-pass type I membrane protein Golgi apparatus, Golgi stack membrane Single-pass type I membrane protein Endoplasmic reticulum membrane Single-pass type I membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane Single-pass type I membrane protein Note=Cycles between compartments of the early secretatory pathway. |
Domain |
PF01105 emp24/gp25L/p24 family/GOLD |
Function |
Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing. |
Biological Process |
GO:0000578 embryonic axis specification GO:0001701 in utero embryonic development GO:0001756 somitogenesis GO:0001838 embryonic epithelial tube formation GO:0001841 neural tube formation GO:0001843 neural tube closure GO:0001890 placenta development GO:0001892 embryonic placenta development GO:0001893 maternal placenta development GO:0001947 heart looping GO:0003002 regionalization GO:0003007 heart morphogenesis GO:0003143 embryonic heart tube morphogenesis GO:0006612 protein targeting to membrane GO:0006888 ER to Golgi vesicle-mediated transport GO:0006890 retrograde vesicle-mediated transport, Golgi to ER GO:0006900 membrane budding GO:0006901 vesicle coating GO:0006903 vesicle targeting GO:0007009 plasma membrane organization GO:0007030 Golgi organization GO:0007368 determination of left/right symmetry GO:0007389 pattern specification process GO:0007507 heart development GO:0007565 female pregnancy GO:0009798 axis specification GO:0009799 specification of symmetry GO:0009855 determination of bilateral symmetry GO:0009880 embryonic pattern specification GO:0009948 anterior/posterior axis specification GO:0009952 anterior/posterior pattern specification GO:0014020 primary neural tube formation GO:0016050 vesicle organization GO:0016331 morphogenesis of embryonic epithelium GO:0021915 neural tube development GO:0032525 somite rostral/caudal axis specification GO:0034260 negative regulation of GTPase activity GO:0035050 embryonic heart tube development GO:0035148 tube formation GO:0035239 tube morphogenesis GO:0035264 multicellular organism growth GO:0035282 segmentation GO:0035459 cargo loading into vesicle GO:0035964 COPI-coated vesicle budding GO:0036342 post-anal tail morphogenesis GO:0044706 multi-multicellular organism process GO:0048193 Golgi vesicle transport GO:0048194 Golgi vesicle budding GO:0048199 vesicle targeting, to, from or within Golgi GO:0048200 Golgi transport vesicle coating GO:0048205 COPI coating of Golgi vesicle GO:0048207 vesicle targeting, rough ER to cis-Golgi GO:0048208 COPII vesicle coating GO:0048562 embryonic organ morphogenesis GO:0048568 embryonic organ development GO:0048608 reproductive structure development GO:0051346 negative regulation of hydrolase activity GO:0051640 organelle localization GO:0051648 vesicle localization GO:0051650 establishment of vesicle localization GO:0051656 establishment of organelle localization GO:0060135 maternal process involved in female pregnancy GO:0060562 epithelial tube morphogenesis GO:0060606 tube closure GO:0060674 placenta blood vessel development GO:0060711 labyrinthine layer development GO:0060716 labyrinthine layer blood vessel development GO:0061053 somite development GO:0061371 determination of heart left/right asymmetry GO:0061458 reproductive system development GO:0072175 epithelial tube formation GO:0072657 protein localization to membrane GO:0072659 protein localization to plasma membrane GO:0072661 protein targeting to plasma membrane GO:0090002 establishment of protein localization to plasma membrane GO:0090114 COPII-coated vesicle budding GO:0090150 establishment of protein localization to membrane GO:1990778 protein localization to cell periphery |
Molecular Function | - |
Cellular Component |
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment GO:0005795 Golgi stack GO:0005798 Golgi-associated vesicle GO:0012507 ER to Golgi transport vesicle membrane GO:0030133 transport vesicle GO:0030134 ER to Golgi transport vesicle GO:0030135 coated vesicle GO:0030137 COPI-coated vesicle GO:0030141 secretory granule GO:0030658 transport vesicle membrane GO:0030659 cytoplasmic vesicle membrane GO:0030660 Golgi-associated vesicle membrane GO:0030662 coated vesicle membrane GO:0030663 COPI-coated vesicle membrane GO:0030667 secretory granule membrane GO:0031984 organelle subcompartment GO:0031985 Golgi cisterna GO:0032580 Golgi cisterna membrane GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane GO:0042588 zymogen granule GO:0042589 zymogen granule membrane GO:0098791 Golgi subcompartment GO:0099503 secretory vesicle |
KEGG | - |
Reactome |
R-HSA-446203: Asparagine N-linked glycosylation R-HSA-6811434: COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6807878: COPI-mediated anterograde transport R-HSA-204005: COPII (Coat Protein 2) Mediated Vesicle Transport R-HSA-5694530: Cargo concentration in the ER R-HSA-199977: ER to Golgi Anterograde Transport R-HSA-8856688: Golgi-to-ER retrograde transport R-HSA-6811442: Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-199991: Membrane Trafficking R-HSA-392499: Metabolism of proteins R-HSA-597592: Post-translational protein modification R-HSA-1912422: Pre-NOTCH Expression and Processing R-HSA-1912420: Pre-NOTCH Processing in Golgi R-HSA-162582: Signal Transduction R-HSA-157118: Signaling by NOTCH R-HSA-948021: Transport to the Golgi and subsequent modification R-HSA-5653656: Vesicle-mediated transport |
Summary | |
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Symbol | TMED2 |
Name | transmembrane p24 trafficking protein 2 |
Aliases | RNP24; P24A; p24beta1; p24b1; transmembrane emp24 domain trafficking protein 2; coated vesicle membrane prot ...... |
Chromosomal Location | 12q24.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TMED2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TMED2 |
Name | transmembrane p24 trafficking protein 2 |
Aliases | RNP24; P24A; p24beta1; p24b1; transmembrane emp24 domain trafficking protein 2; coated vesicle membrane prot ...... |
Chromosomal Location | 12q24.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TMED2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TMED2 |
Name | transmembrane p24 trafficking protein 2 |
Aliases | RNP24; P24A; p24beta1; p24b1; transmembrane emp24 domain trafficking protein 2; coated vesicle membrane prot ...... |
Chromosomal Location | 12q24.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TMED2 in various data sets.
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There is no record. |
Summary | |
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Symbol | TMED2 |
Name | transmembrane p24 trafficking protein 2 |
Aliases | RNP24; P24A; p24beta1; p24b1; transmembrane emp24 domain trafficking protein 2; coated vesicle membrane prot ...... |
Chromosomal Location | 12q24.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TMED2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | TMED2 |
Name | transmembrane p24 trafficking protein 2 |
Aliases | RNP24; P24A; p24beta1; p24b1; transmembrane emp24 domain trafficking protein 2; coated vesicle membrane prot ...... |
Chromosomal Location | 12q24.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TMED2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TMED2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TMED2 |
Name | transmembrane p24 trafficking protein 2 |
Aliases | RNP24; P24A; p24beta1; p24b1; transmembrane emp24 domain trafficking protein 2; coated vesicle membrane prot ...... |
Chromosomal Location | 12q24.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TMED2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TMED2 |
Name | transmembrane p24 trafficking protein 2 |
Aliases | RNP24; P24A; p24beta1; p24b1; transmembrane emp24 domain trafficking protein 2; coated vesicle membrane prot ...... |
Chromosomal Location | 12q24.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TMED2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TMED2 |
Name | transmembrane p24 trafficking protein 2 |
Aliases | RNP24; P24A; p24beta1; p24b1; transmembrane emp24 domain trafficking protein 2; coated vesicle membrane prot ...... |
Chromosomal Location | 12q24.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TMED2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | TMED2 |
Name | transmembrane p24 trafficking protein 2 |
Aliases | RNP24; P24A; p24beta1; p24b1; transmembrane emp24 domain trafficking protein 2; coated vesicle membrane prot ...... |
Chromosomal Location | 12q24.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TMED2 collected from DrugBank database. |
There is no record. |