Summary | |
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Symbol | TMED5 |
Name | transmembrane p24 trafficking protein 5 |
Aliases | CGI-100; p24g2; p24gamma2; transmembrane emp24 protein transport domain containing 5; p24 family protein gam ...... |
Chromosomal Location | 1p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Endoplasmic reticulum membrane Single-pass type I membrane protein Golgi apparatus, cis-Golgi network membrane Single-pass type I membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane Single-pass type I membrane protein Note=Probably cycles between compartments of the early secretatory pathway. |
Domain |
PF01105 emp24/gp25L/p24 family/GOLD |
Function |
Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport. |
Biological Process |
GO:0007030 Golgi organization GO:0090161 Golgi ribbon formation |
Molecular Function | - |
Cellular Component |
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment GO:0005801 cis-Golgi network GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane GO:0070971 endoplasmic reticulum exit site |
KEGG | - |
Reactome |
R-HSA-162582: Signal Transduction R-HSA-195721: Signaling by Wnt R-HSA-3238698: WNT ligand biogenesis and trafficking |
Summary | |
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Symbol | TMED5 |
Name | transmembrane p24 trafficking protein 5 |
Aliases | CGI-100; p24g2; p24gamma2; transmembrane emp24 protein transport domain containing 5; p24 family protein gam ...... |
Chromosomal Location | 1p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TMED5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TMED5 |
Name | transmembrane p24 trafficking protein 5 |
Aliases | CGI-100; p24g2; p24gamma2; transmembrane emp24 protein transport domain containing 5; p24 family protein gam ...... |
Chromosomal Location | 1p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TMED5 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TMED5 |
Name | transmembrane p24 trafficking protein 5 |
Aliases | CGI-100; p24g2; p24gamma2; transmembrane emp24 protein transport domain containing 5; p24 family protein gam ...... |
Chromosomal Location | 1p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TMED5 in various data sets.
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Points in the above scatter plot represent the mutation difference of TMED5 in various data sets.
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Summary | |
---|---|
Symbol | TMED5 |
Name | transmembrane p24 trafficking protein 5 |
Aliases | CGI-100; p24g2; p24gamma2; transmembrane emp24 protein transport domain containing 5; p24 family protein gam ...... |
Chromosomal Location | 1p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TMED5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | TMED5 |
Name | transmembrane p24 trafficking protein 5 |
Aliases | CGI-100; p24g2; p24gamma2; transmembrane emp24 protein transport domain containing 5; p24 family protein gam ...... |
Chromosomal Location | 1p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TMED5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TMED5. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TMED5 |
Name | transmembrane p24 trafficking protein 5 |
Aliases | CGI-100; p24g2; p24gamma2; transmembrane emp24 protein transport domain containing 5; p24 family protein gam ...... |
Chromosomal Location | 1p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TMED5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | TMED5 |
Name | transmembrane p24 trafficking protein 5 |
Aliases | CGI-100; p24g2; p24gamma2; transmembrane emp24 protein transport domain containing 5; p24 family protein gam ...... |
Chromosomal Location | 1p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TMED5 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | TMED5 |
Name | transmembrane p24 trafficking protein 5 |
Aliases | CGI-100; p24g2; p24gamma2; transmembrane emp24 protein transport domain containing 5; p24 family protein gam ...... |
Chromosomal Location | 1p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TMED5 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TMED5 |
Name | transmembrane p24 trafficking protein 5 |
Aliases | CGI-100; p24g2; p24gamma2; transmembrane emp24 protein transport domain containing 5; p24 family protein gam ...... |
Chromosomal Location | 1p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TMED5 collected from DrugBank database. |
There is no record. |