Summary | |
---|---|
Symbol | TMEFF2 |
Name | transmembrane protein with EGF-like and two follistatin-like domains 2 |
Aliases | TENB2; TPEF; CT120.2; transmembrane protein TENB2; tomoregulin; cancer/testis antigen family 120, member 2; ...... |
Chromosomal Location | 2q32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Isoform 1: Membrane Single-pass type I membrane protein ; SUBCELLULAR LOCATION: Isoform 2: Membrane Single-pass type I membrane protein ; SUBCELLULAR LOCATION: Isoform 3: Secreted. |
Domain |
PF07648 Kazal-type serine protease inhibitor domain |
Function |
May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation. |
Biological Process |
GO:0002011 morphogenesis of an epithelial sheet GO:0007009 plasma membrane organization GO:0007015 actin filament organization GO:0010639 negative regulation of organelle organization GO:0030038 contractile actin filament bundle assembly GO:0030336 negative regulation of cell migration GO:0031032 actomyosin structure organization GO:0032231 regulation of actin filament bundle assembly GO:0032232 negative regulation of actin filament bundle assembly GO:0032956 regulation of actin cytoskeleton organization GO:0032970 regulation of actin filament-based process GO:0040013 negative regulation of locomotion GO:0043149 stress fiber assembly GO:0044319 wound healing, spreading of cells GO:0045112 integrin biosynthetic process GO:0045113 regulation of integrin biosynthetic process GO:0045720 negative regulation of integrin biosynthetic process GO:0051017 actin filament bundle assembly GO:0051271 negative regulation of cellular component movement GO:0051492 regulation of stress fiber assembly GO:0051493 regulation of cytoskeleton organization GO:0051494 negative regulation of cytoskeleton organization GO:0051497 negative regulation of stress fiber assembly GO:0061572 actin filament bundle organization GO:0090504 epiboly GO:0090505 epiboly involved in wound healing GO:1903729 regulation of plasma membrane organization GO:2000146 negative regulation of cell motility |
Molecular Function | - |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | TMEFF2 |
Name | transmembrane protein with EGF-like and two follistatin-like domains 2 |
Aliases | TENB2; TPEF; CT120.2; transmembrane protein TENB2; tomoregulin; cancer/testis antigen family 120, member 2; ...... |
Chromosomal Location | 2q32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TMEFF2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TMEFF2 |
Name | transmembrane protein with EGF-like and two follistatin-like domains 2 |
Aliases | TENB2; TPEF; CT120.2; transmembrane protein TENB2; tomoregulin; cancer/testis antigen family 120, member 2; ...... |
Chromosomal Location | 2q32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of TMEFF2 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | TMEFF2 |
Name | transmembrane protein with EGF-like and two follistatin-like domains 2 |
Aliases | TENB2; TPEF; CT120.2; transmembrane protein TENB2; tomoregulin; cancer/testis antigen family 120, member 2; ...... |
Chromosomal Location | 2q32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TMEFF2 in various data sets.
|
Points in the above scatter plot represent the mutation difference of TMEFF2 in various data sets.
|
Summary | |
---|---|
Symbol | TMEFF2 |
Name | transmembrane protein with EGF-like and two follistatin-like domains 2 |
Aliases | TENB2; TPEF; CT120.2; transmembrane protein TENB2; tomoregulin; cancer/testis antigen family 120, member 2; ...... |
Chromosomal Location | 2q32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TMEFF2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TMEFF2 |
Name | transmembrane protein with EGF-like and two follistatin-like domains 2 |
Aliases | TENB2; TPEF; CT120.2; transmembrane protein TENB2; tomoregulin; cancer/testis antigen family 120, member 2; ...... |
Chromosomal Location | 2q32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TMEFF2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TMEFF2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | TMEFF2 |
Name | transmembrane protein with EGF-like and two follistatin-like domains 2 |
Aliases | TENB2; TPEF; CT120.2; transmembrane protein TENB2; tomoregulin; cancer/testis antigen family 120, member 2; ...... |
Chromosomal Location | 2q32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TMEFF2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TMEFF2 |
Name | transmembrane protein with EGF-like and two follistatin-like domains 2 |
Aliases | TENB2; TPEF; CT120.2; transmembrane protein TENB2; tomoregulin; cancer/testis antigen family 120, member 2; ...... |
Chromosomal Location | 2q32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TMEFF2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TMEFF2 |
Name | transmembrane protein with EGF-like and two follistatin-like domains 2 |
Aliases | TENB2; TPEF; CT120.2; transmembrane protein TENB2; tomoregulin; cancer/testis antigen family 120, member 2; ...... |
Chromosomal Location | 2q32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TMEFF2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TMEFF2 |
Name | transmembrane protein with EGF-like and two follistatin-like domains 2 |
Aliases | TENB2; TPEF; CT120.2; transmembrane protein TENB2; tomoregulin; cancer/testis antigen family 120, member 2; ...... |
Chromosomal Location | 2q32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TMEFF2 collected from DrugBank database. |
There is no record. |