Summary | |
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Symbol | TMEM127 |
Name | transmembrane protein 127 |
Aliases | FLJ20507; FLJ22257 |
Chromosomal Location | 2q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Multi-pass membrane protein Cytoplasm Note=Association of TMEM127 with the cell membrane is enhanced by inhibition of endocytosis. In the cytoplasm, it colocalizes with markers of early endosomal structures, Golgi apparatus and lysosomes. |
Domain | - |
Function |
Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1. May act as a tumor suppressor. |
Biological Process |
GO:0007032 endosome organization GO:0007033 vacuole organization GO:0031929 TOR signaling GO:0032006 regulation of TOR signaling GO:0032007 negative regulation of TOR signaling GO:1902532 negative regulation of intracellular signal transduction |
Molecular Function |
GO:0017016 Ras GTPase binding GO:0017137 Rab GTPase binding GO:0031267 small GTPase binding GO:0051020 GTPase binding |
Cellular Component |
GO:0005769 early endosome |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | TMEM127 |
Name | transmembrane protein 127 |
Aliases | FLJ20507; FLJ22257 |
Chromosomal Location | 2q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TMEM127 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TMEM127 |
Name | transmembrane protein 127 |
Aliases | FLJ20507; FLJ22257 |
Chromosomal Location | 2q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TMEM127 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | TMEM127 |
Name | transmembrane protein 127 |
Aliases | FLJ20507; FLJ22257 |
Chromosomal Location | 2q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TMEM127 in various data sets.
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Points in the above scatter plot represent the mutation difference of TMEM127 in various data sets.
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Summary | |
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Symbol | TMEM127 |
Name | transmembrane protein 127 |
Aliases | FLJ20507; FLJ22257 |
Chromosomal Location | 2q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TMEM127. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TMEM127 |
Name | transmembrane protein 127 |
Aliases | FLJ20507; FLJ22257 |
Chromosomal Location | 2q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TMEM127. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TMEM127. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TMEM127 |
Name | transmembrane protein 127 |
Aliases | FLJ20507; FLJ22257 |
Chromosomal Location | 2q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TMEM127. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | TMEM127 |
Name | transmembrane protein 127 |
Aliases | FLJ20507; FLJ22257 |
Chromosomal Location | 2q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TMEM127 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TMEM127 |
Name | transmembrane protein 127 |
Aliases | FLJ20507; FLJ22257 |
Chromosomal Location | 2q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TMEM127 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |