Summary | |
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Symbol | TMEM204 |
Name | transmembrane protein 204 |
Aliases | FLJ20898; CLP24; claudin-like protein of 24 kDa; C16orf30; chromosome 16 open reading frame 30; claudin-like ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell junction, adherens junction Cell membrane Multi-pass membrane protein Note=Colocalizes with the beta-catenin adherins. |
Domain | - |
Function |
Can influence paracellular permeability. Appears to be involved in cell-cell interactions through adherens. |
Biological Process |
GO:0001945 lymph vessel development GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway GO:0042692 muscle cell differentiation GO:0048010 vascular endothelial growth factor receptor signaling pathway GO:0051145 smooth muscle cell differentiation GO:0090287 regulation of cellular response to growth factor stimulus |
Molecular Function | - |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | TMEM204 |
Name | transmembrane protein 204 |
Aliases | FLJ20898; CLP24; claudin-like protein of 24 kDa; C16orf30; chromosome 16 open reading frame 30; claudin-like ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TMEM204 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TMEM204 |
Name | transmembrane protein 204 |
Aliases | FLJ20898; CLP24; claudin-like protein of 24 kDa; C16orf30; chromosome 16 open reading frame 30; claudin-like ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TMEM204 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TMEM204 |
Name | transmembrane protein 204 |
Aliases | FLJ20898; CLP24; claudin-like protein of 24 kDa; C16orf30; chromosome 16 open reading frame 30; claudin-like ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TMEM204 in various data sets.
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Points in the above scatter plot represent the mutation difference of TMEM204 in various data sets.
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Summary | |
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Symbol | TMEM204 |
Name | transmembrane protein 204 |
Aliases | FLJ20898; CLP24; claudin-like protein of 24 kDa; C16orf30; chromosome 16 open reading frame 30; claudin-like ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TMEM204. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TMEM204 |
Name | transmembrane protein 204 |
Aliases | FLJ20898; CLP24; claudin-like protein of 24 kDa; C16orf30; chromosome 16 open reading frame 30; claudin-like ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TMEM204. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TMEM204. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TMEM204 |
Name | transmembrane protein 204 |
Aliases | FLJ20898; CLP24; claudin-like protein of 24 kDa; C16orf30; chromosome 16 open reading frame 30; claudin-like ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TMEM204. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | TMEM204 |
Name | transmembrane protein 204 |
Aliases | FLJ20898; CLP24; claudin-like protein of 24 kDa; C16orf30; chromosome 16 open reading frame 30; claudin-like ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TMEM204 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | TMEM204 |
Name | transmembrane protein 204 |
Aliases | FLJ20898; CLP24; claudin-like protein of 24 kDa; C16orf30; chromosome 16 open reading frame 30; claudin-like ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TMEM204 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TMEM204 |
Name | transmembrane protein 204 |
Aliases | FLJ20898; CLP24; claudin-like protein of 24 kDa; C16orf30; chromosome 16 open reading frame 30; claudin-like ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TMEM204 collected from DrugBank database. |
There is no record. |