Summary | |
---|---|
Symbol | TMEM64 |
Name | transmembrane protein 64 |
Aliases | DKFZp762C1112 |
Chromosomal Location | 8q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Multi-pass membrane protein Endoplasmic reticulum |
Domain |
PF09335 SNARE associated Golgi protein |
Function |
Positively regulates TNFSF11-induced osteoclast differentiation. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with SERCA2 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation. Negatively regulates osteoblast differentiation and positively regulates adipocyte differentiation via modulation of the canonical Wnt signaling pathway. Mediates the switch in lineage commitment to osteogenesis rather than to adipogenesis in mesenchymal stem cells by negatively regulating the expression, activity and nuclear localization of CTNNB1. |
Biological Process |
GO:0001503 ossification GO:0001649 osteoblast differentiation GO:0001894 tissue homeostasis GO:0002521 leukocyte differentiation GO:0002573 myeloid leukocyte differentiation GO:0002761 regulation of myeloid leukocyte differentiation GO:0002763 positive regulation of myeloid leukocyte differentiation GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0016055 Wnt signaling pathway GO:0030099 myeloid cell differentiation GO:0030111 regulation of Wnt signaling pathway GO:0030178 negative regulation of Wnt signaling pathway GO:0030278 regulation of ossification GO:0030279 negative regulation of ossification GO:0030316 osteoclast differentiation GO:0032844 regulation of homeostatic process GO:0032846 positive regulation of homeostatic process GO:0034103 regulation of tissue remodeling GO:0034105 positive regulation of tissue remodeling GO:0043462 regulation of ATPase activity GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation GO:0045124 regulation of bone resorption GO:0045444 fat cell differentiation GO:0045453 bone resorption GO:0045598 regulation of fat cell differentiation GO:0045600 positive regulation of fat cell differentiation GO:0045637 regulation of myeloid cell differentiation GO:0045639 positive regulation of myeloid cell differentiation GO:0045667 regulation of osteoblast differentiation GO:0045668 negative regulation of osteoblast differentiation GO:0045670 regulation of osteoclast differentiation GO:0045672 positive regulation of osteoclast differentiation GO:0045780 positive regulation of bone resorption GO:0046849 bone remodeling GO:0046850 regulation of bone remodeling GO:0046852 positive regulation of bone remodeling GO:0048771 tissue remodeling GO:0048871 multicellular organismal homeostasis GO:0051480 regulation of cytosolic calcium ion concentration GO:0055074 calcium ion homeostasis GO:0060070 canonical Wnt signaling pathway GO:0060249 anatomical structure homeostasis GO:0060828 regulation of canonical Wnt signaling pathway GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0090090 negative regulation of canonical Wnt signaling pathway GO:0198738 cell-cell signaling by wnt GO:1902105 regulation of leukocyte differentiation GO:1902107 positive regulation of leukocyte differentiation GO:1903706 regulation of hemopoiesis GO:1903708 positive regulation of hemopoiesis |
Molecular Function | - |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | TMEM64 |
Name | transmembrane protein 64 |
Aliases | DKFZp762C1112 |
Chromosomal Location | 8q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TMEM64 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TMEM64 |
Name | transmembrane protein 64 |
Aliases | DKFZp762C1112 |
Chromosomal Location | 8q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TMEM64 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | TMEM64 |
Name | transmembrane protein 64 |
Aliases | DKFZp762C1112 |
Chromosomal Location | 8q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TMEM64 in various data sets.
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There is no record. |
Summary | |
---|---|
Symbol | TMEM64 |
Name | transmembrane protein 64 |
Aliases | DKFZp762C1112 |
Chromosomal Location | 8q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TMEM64. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TMEM64 |
Name | transmembrane protein 64 |
Aliases | DKFZp762C1112 |
Chromosomal Location | 8q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TMEM64. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TMEM64. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | TMEM64 |
Name | transmembrane protein 64 |
Aliases | DKFZp762C1112 |
Chromosomal Location | 8q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TMEM64. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TMEM64 |
Name | transmembrane protein 64 |
Aliases | DKFZp762C1112 |
Chromosomal Location | 8q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TMEM64 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TMEM64 |
Name | transmembrane protein 64 |
Aliases | DKFZp762C1112 |
Chromosomal Location | 8q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TMEM64 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |