Summary | |
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Symbol | TMPRSS3 |
Name | transmembrane protease, serine 3 |
Aliases | DFNB10; DFNB8; ECHOS1; TADG12; serine protease TADG-12; tumor-associated differentially-expressed gene 12 pr ...... |
Chromosomal Location | 21q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Endoplasmic reticulum membrane Single-pass type II membrane protein |
Domain |
PF00057 Low-density lipoprotein receptor domain class A PF15494 Scavenger receptor cysteine-rich domain PF00089 Trypsin |
Function |
Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity). Activates ENaC (in vitro). |
Biological Process |
GO:0006875 cellular metal ion homeostasis GO:0006883 cellular sodium ion homeostasis GO:0006898 receptor-mediated endocytosis GO:0007605 sensory perception of sound GO:0030004 cellular monovalent inorganic cation homeostasis GO:0050954 sensory perception of mechanical stimulus GO:0055067 monovalent inorganic cation homeostasis GO:0055078 sodium ion homeostasis |
Molecular Function |
GO:0004175 endopeptidase activity GO:0004252 serine-type endopeptidase activity GO:0005044 scavenger receptor activity GO:0008236 serine-type peptidase activity GO:0016247 channel regulator activity GO:0017080 sodium channel regulator activity GO:0017171 serine hydrolase activity GO:0038024 cargo receptor activity |
Cellular Component |
GO:0043025 neuronal cell body GO:0044297 cell body |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | TMPRSS3 |
Name | transmembrane protease, serine 3 |
Aliases | DFNB10; DFNB8; ECHOS1; TADG12; serine protease TADG-12; tumor-associated differentially-expressed gene 12 pr ...... |
Chromosomal Location | 21q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TMPRSS3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TMPRSS3 |
Name | transmembrane protease, serine 3 |
Aliases | DFNB10; DFNB8; ECHOS1; TADG12; serine protease TADG-12; tumor-associated differentially-expressed gene 12 pr ...... |
Chromosomal Location | 21q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TMPRSS3 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | TMPRSS3 |
Name | transmembrane protease, serine 3 |
Aliases | DFNB10; DFNB8; ECHOS1; TADG12; serine protease TADG-12; tumor-associated differentially-expressed gene 12 pr ...... |
Chromosomal Location | 21q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TMPRSS3 in various data sets.
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Points in the above scatter plot represent the mutation difference of TMPRSS3 in various data sets.
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Summary | |
---|---|
Symbol | TMPRSS3 |
Name | transmembrane protease, serine 3 |
Aliases | DFNB10; DFNB8; ECHOS1; TADG12; serine protease TADG-12; tumor-associated differentially-expressed gene 12 pr ...... |
Chromosomal Location | 21q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TMPRSS3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TMPRSS3 |
Name | transmembrane protease, serine 3 |
Aliases | DFNB10; DFNB8; ECHOS1; TADG12; serine protease TADG-12; tumor-associated differentially-expressed gene 12 pr ...... |
Chromosomal Location | 21q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TMPRSS3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TMPRSS3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TMPRSS3 |
Name | transmembrane protease, serine 3 |
Aliases | DFNB10; DFNB8; ECHOS1; TADG12; serine protease TADG-12; tumor-associated differentially-expressed gene 12 pr ...... |
Chromosomal Location | 21q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TMPRSS3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TMPRSS3 |
Name | transmembrane protease, serine 3 |
Aliases | DFNB10; DFNB8; ECHOS1; TADG12; serine protease TADG-12; tumor-associated differentially-expressed gene 12 pr ...... |
Chromosomal Location | 21q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TMPRSS3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TMPRSS3 |
Name | transmembrane protease, serine 3 |
Aliases | DFNB10; DFNB8; ECHOS1; TADG12; serine protease TADG-12; tumor-associated differentially-expressed gene 12 pr ...... |
Chromosomal Location | 21q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TMPRSS3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TMPRSS3 |
Name | transmembrane protease, serine 3 |
Aliases | DFNB10; DFNB8; ECHOS1; TADG12; serine protease TADG-12; tumor-associated differentially-expressed gene 12 pr ...... |
Chromosomal Location | 21q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TMPRSS3 collected from DrugBank database. |
There is no record. |