Summary | |
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Symbol | TMSB15B |
Name | thymosin beta 15B |
Aliases | MGC39900; Tbeta15b |
Chromosomal Location | Xq22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm, cytoskeleton |
Domain |
PF01290 Thymosin beta-4 family |
Function |
Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity). May be involved in cell migration. |
Biological Process |
GO:0007015 actin filament organization GO:0008064 regulation of actin polymerization or depolymerization GO:0008154 actin polymerization or depolymerization GO:0010639 negative regulation of organelle organization GO:0030041 actin filament polymerization GO:0030832 regulation of actin filament length GO:0030833 regulation of actin filament polymerization GO:0030837 negative regulation of actin filament polymerization GO:0031333 negative regulation of protein complex assembly GO:0032271 regulation of protein polymerization GO:0032272 negative regulation of protein polymerization GO:0032507 maintenance of protein location in cell GO:0032535 regulation of cellular component size GO:0032956 regulation of actin cytoskeleton organization GO:0032970 regulation of actin filament-based process GO:0042989 sequestering of actin monomers GO:0043254 regulation of protein complex assembly GO:0045185 maintenance of protein location GO:0051235 maintenance of location GO:0051258 protein polymerization GO:0051493 regulation of cytoskeleton organization GO:0051494 negative regulation of cytoskeleton organization GO:0051651 maintenance of location in cell GO:0090066 regulation of anatomical structure size |
Molecular Function |
GO:0003779 actin binding GO:0003785 actin monomer binding |
Cellular Component |
GO:0005884 actin filament GO:0015629 actin cytoskeleton GO:0031941 filamentous actin |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | TMSB15B |
Name | thymosin beta 15B |
Aliases | MGC39900; Tbeta15b |
Chromosomal Location | Xq22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TMSB15B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TMSB15B |
Name | thymosin beta 15B |
Aliases | MGC39900; Tbeta15b |
Chromosomal Location | Xq22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TMSB15B in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | TMSB15B |
Name | thymosin beta 15B |
Aliases | MGC39900; Tbeta15b |
Chromosomal Location | Xq22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TMSB15B in various data sets.
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Points in the above scatter plot represent the mutation difference of TMSB15B in various data sets.
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Summary | |
---|---|
Symbol | TMSB15B |
Name | thymosin beta 15B |
Aliases | MGC39900; Tbeta15b |
Chromosomal Location | Xq22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TMSB15B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TMSB15B |
Name | thymosin beta 15B |
Aliases | MGC39900; Tbeta15b |
Chromosomal Location | Xq22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TMSB15B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TMSB15B. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | TMSB15B |
Name | thymosin beta 15B |
Aliases | MGC39900; Tbeta15b |
Chromosomal Location | Xq22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TMSB15B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TMSB15B |
Name | thymosin beta 15B |
Aliases | MGC39900; Tbeta15b |
Chromosomal Location | Xq22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TMSB15B expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TMSB15B |
Name | thymosin beta 15B |
Aliases | MGC39900; Tbeta15b |
Chromosomal Location | Xq22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TMSB15B and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |