Summary | |
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Symbol | TNFAIP3 |
Name | tumor necrosis factor, alpha-induced protein 3 |
Aliases | OTUD7C; TNFA1P2; OTU domain-containing protein 7C; TNF alpha-induced protein 3; putative DNA-binding protein ...... |
Chromosomal Location | 6q23-q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. Nucleus. Lysosome.; SUBCELLULAR LOCATION: A20p50: Cytoplasm. |
Domain |
PF02338 OTU-like cysteine protease PF01754 A20-like zinc finger |
Function |
Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Required for LPS-induced production of proinflammatory cytokines and IFN beta in LPS-tolerized macrophages. |
Biological Process |
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000209 protein polyubiquitination GO:0000302 response to reactive oxygen species GO:0001525 angiogenesis GO:0001776 leukocyte homeostasis GO:0001782 B cell homeostasis GO:0001818 negative regulation of cytokine production GO:0001889 liver development GO:0001894 tissue homeostasis GO:0001922 B-1 B cell homeostasis GO:0001933 negative regulation of protein phosphorylation GO:0001959 regulation of cytokine-mediated signaling pathway GO:0002158 osteoclast proliferation GO:0002218 activation of innate immune response GO:0002221 pattern recognition receptor signaling pathway GO:0002224 toll-like receptor signaling pathway GO:0002237 response to molecule of bacterial origin GO:0002250 adaptive immune response GO:0002260 lymphocyte homeostasis GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002467 germinal center formation GO:0002507 tolerance induction GO:0002544 chronic inflammatory response GO:0002634 regulation of germinal center formation GO:0002676 regulation of chronic inflammatory response GO:0002677 negative regulation of chronic inflammatory response GO:0002683 negative regulation of immune system process GO:0002694 regulation of leukocyte activation GO:0002695 negative regulation of leukocyte activation GO:0002697 regulation of immune effector process GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0002757 immune response-activating signal transduction GO:0002758 innate immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0002819 regulation of adaptive immune response GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002831 regulation of response to biotic stimulus GO:0002832 negative regulation of response to biotic stimulus GO:0006469 negative regulation of protein kinase activity GO:0006979 response to oxidative stress GO:0007249 I-kappaB kinase/NF-kappaB signaling GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors GO:0009615 response to virus GO:0009894 regulation of catabolic process GO:0009896 positive regulation of catabolic process GO:0010035 response to inorganic substance GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway GO:0016579 protein deubiquitination GO:0022612 gland morphogenesis GO:0023035 CD40 signaling pathway GO:0030522 intracellular receptor signaling pathway GO:0031329 regulation of cellular catabolic process GO:0031331 positive regulation of cellular catabolic process GO:0031348 negative regulation of defense response GO:0031349 positive regulation of defense response GO:0031396 regulation of protein ubiquitination GO:0031397 negative regulation of protein ubiquitination GO:0031663 lipopolysaccharide-mediated signaling pathway GO:0031664 regulation of lipopolysaccharide-mediated signaling pathway GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway GO:0032088 negative regulation of NF-kappaB transcription factor activity GO:0032102 negative regulation of response to external stimulus GO:0032479 regulation of type I interferon production GO:0032480 negative regulation of type I interferon production GO:0032495 response to muramyl dipeptide GO:0032496 response to lipopolysaccharide GO:0032606 type I interferon production GO:0032611 interleukin-1 beta production GO:0032612 interleukin-1 production GO:0032623 interleukin-2 production GO:0032635 interleukin-6 production GO:0032640 tumor necrosis factor production GO:0032651 regulation of interleukin-1 beta production GO:0032652 regulation of interleukin-1 production GO:0032663 regulation of interleukin-2 production GO:0032675 regulation of interleukin-6 production GO:0032680 regulation of tumor necrosis factor production GO:0032691 negative regulation of interleukin-1 beta production GO:0032692 negative regulation of interleukin-1 production GO:0032703 negative regulation of interleukin-2 production GO:0032715 negative regulation of interleukin-6 production GO:0032720 negative regulation of tumor necrosis factor production GO:0032844 regulation of homeostatic process GO:0032845 negative regulation of homeostatic process GO:0033002 muscle cell proliferation GO:0033209 tumor necrosis factor-mediated signaling pathway GO:0033673 negative regulation of kinase activity GO:0034103 regulation of tissue remodeling GO:0034104 negative regulation of tissue remodeling GO:0034121 regulation of toll-like receptor signaling pathway GO:0034122 negative regulation of toll-like receptor signaling pathway GO:0034134 toll-like receptor 2 signaling pathway GO:0034135 regulation of toll-like receptor 2 signaling pathway GO:0034136 negative regulation of toll-like receptor 2 signaling pathway GO:0034138 toll-like receptor 3 signaling pathway GO:0034139 regulation of toll-like receptor 3 signaling pathway GO:0034140 negative regulation of toll-like receptor 3 signaling pathway GO:0034142 toll-like receptor 4 signaling pathway GO:0034143 regulation of toll-like receptor 4 signaling pathway GO:0034144 negative regulation of toll-like receptor 4 signaling pathway GO:0034146 toll-like receptor 5 signaling pathway GO:0034147 regulation of toll-like receptor 5 signaling pathway GO:0034148 negative regulation of toll-like receptor 5 signaling pathway GO:0034599 cellular response to oxidative stress GO:0034612 response to tumor necrosis factor GO:0034614 cellular response to reactive oxygen species GO:0035871 protein K11-linked deubiquitination GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway GO:0042113 B cell activation GO:0042176 regulation of protein catabolic process GO:0042326 negative regulation of phosphorylation GO:0042542 response to hydrogen peroxide GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity GO:0043900 regulation of multi-organism process GO:0043901 negative regulation of multi-organism process GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism GO:0045088 regulation of innate immune response GO:0045089 positive regulation of innate immune response GO:0045124 regulation of bone resorption GO:0045453 bone resorption GO:0045732 positive regulation of protein catabolic process GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045765 regulation of angiogenesis GO:0045779 negative regulation of bone resorption GO:0045786 negative regulation of cell cycle GO:0045824 negative regulation of innate immune response GO:0046849 bone remodeling GO:0046850 regulation of bone remodeling GO:0046851 negative regulation of bone remodeling GO:0048514 blood vessel morphogenesis GO:0048659 smooth muscle cell proliferation GO:0048660 regulation of smooth muscle cell proliferation GO:0048662 negative regulation of smooth muscle cell proliferation GO:0048732 gland development GO:0048771 tissue remodeling GO:0048871 multicellular organismal homeostasis GO:0048872 homeostasis of number of cells GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050679 positive regulation of epithelial cell proliferation GO:0050688 regulation of defense response to virus GO:0050691 regulation of defense response to virus by host GO:0050727 regulation of inflammatory response GO:0050728 negative regulation of inflammatory response GO:0050777 negative regulation of immune response GO:0050792 regulation of viral process GO:0050864 regulation of B cell activation GO:0050865 regulation of cell activation GO:0050866 negative regulation of cell activation GO:0050869 negative regulation of B cell activation GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051249 regulation of lymphocyte activation GO:0051250 negative regulation of lymphocyte activation GO:0051259 protein oligomerization GO:0051348 negative regulation of transferase activity GO:0051607 defense response to virus GO:0060055 angiogenesis involved in wound healing GO:0060249 anatomical structure homeostasis GO:0060759 regulation of response to cytokine stimulus GO:0061008 hepaticobiliary system development GO:0061041 regulation of wound healing GO:0061042 vascular wound healing GO:0061043 regulation of vascular wound healing GO:0070301 cellular response to hydrogen peroxide GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway GO:0070425 negative regulation of nucleotide-binding oligomerization domain containing signaling pathway GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway GO:0070428 regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway GO:0070429 negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0070432 regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0070433 negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0070536 protein K63-linked deubiquitination GO:0070646 protein modification by small protein removal GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0070664 negative regulation of leukocyte proliferation GO:0070936 protein K48-linked ubiquitination GO:0071108 protein K48-linked deubiquitination GO:0071216 cellular response to biotic stimulus GO:0071219 cellular response to molecule of bacterial origin GO:0071222 cellular response to lipopolysaccharide GO:0071356 cellular response to tumor necrosis factor GO:0071396 cellular response to lipid GO:0071706 tumor necrosis factor superfamily cytokine production GO:0071900 regulation of protein serine/threonine kinase activity GO:0071901 negative regulation of protein serine/threonine kinase activity GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process GO:0072573 tolerance induction to lipopolysaccharide GO:0072574 hepatocyte proliferation GO:0072575 epithelial cell proliferation involved in liver morphogenesis GO:0072576 liver morphogenesis GO:0072577 endothelial cell apoptotic process GO:0072665 protein localization to vacuole GO:0072666 establishment of protein localization to vacuole GO:0090289 regulation of osteoclast proliferation GO:0090291 negative regulation of osteoclast proliferation GO:0097191 extrinsic apoptotic signaling pathway GO:0098542 defense response to other organism GO:1901342 regulation of vasculature development GO:1901652 response to peptide GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902532 negative regulation of intracellular signal transduction GO:1903034 regulation of response to wounding GO:1903320 regulation of protein modification by small protein conjugation or removal GO:1903321 negative regulation of protein modification by small protein conjugation or removal GO:1903362 regulation of cellular protein catabolic process GO:1903364 positive regulation of cellular protein catabolic process GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production GO:1904019 epithelial cell apoptotic process GO:1904029 regulation of cyclin-dependent protein kinase activity GO:1904030 negative regulation of cyclin-dependent protein kinase activity GO:1904035 regulation of epithelial cell apoptotic process GO:1904036 negative regulation of epithelial cell apoptotic process GO:2000027 regulation of organ morphogenesis GO:2000345 regulation of hepatocyte proliferation GO:2000347 positive regulation of hepatocyte proliferation GO:2000348 regulation of CD40 signaling pathway GO:2000349 negative regulation of CD40 signaling pathway GO:2000351 regulation of endothelial cell apoptotic process GO:2000352 negative regulation of endothelial cell apoptotic process GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001236 regulation of extrinsic apoptotic signaling pathway GO:2001237 negative regulation of extrinsic apoptotic signaling pathway |
Molecular Function |
GO:0002020 protease binding GO:0004842 ubiquitin-protein transferase activity GO:0004843 thiol-dependent ubiquitin-specific protease activity GO:0008234 cysteine-type peptidase activity GO:0016874 ligase activity GO:0019783 ubiquitin-like protein-specific protease activity GO:0019787 ubiquitin-like protein transferase activity GO:0031593 polyubiquitin binding GO:0032182 ubiquitin-like protein binding GO:0036459 thiol-dependent ubiquitinyl hydrolase activity GO:0043130 ubiquitin binding GO:0043621 protein self-association GO:0070530 K63-linked polyubiquitin binding GO:0101005 ubiquitinyl hydrolase activity |
Cellular Component | - |
KEGG |
hsa04064 NF-kappa B signaling pathway hsa04621 NOD-like receptor signaling pathway hsa04668 TNF signaling pathway |
Reactome |
R-HSA-73887: Death Receptor Signalling R-HSA-5688426: Deubiquitination R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-392499: Metabolism of proteins R-HSA-168638: NOD1/2 Signaling Pathway R-HSA-936440: Negative regulators of RIG-I/MDA5 signaling R-HSA-168643: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-5689896: Ovarian tumor domain proteases R-HSA-597592: Post-translational protein modification R-HSA-168928: RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways R-HSA-5357905: Regulation of TNFR1 signaling R-HSA-162582: Signal Transduction R-HSA-75893: TNF signaling R-HSA-5357956: TNFR1-induced NFkappaB signaling pathway R-HSA-5357786: TNFR1-induced proapoptotic signaling |
Summary | |
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Symbol | TNFAIP3 |
Name | tumor necrosis factor, alpha-induced protein 3 |
Aliases | OTUD7C; TNFA1P2; OTU domain-containing protein 7C; TNF alpha-induced protein 3; putative DNA-binding protein ...... |
Chromosomal Location | 6q23-q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TNFAIP3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between TNFAIP3 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | TNFAIP3 |
Name | tumor necrosis factor, alpha-induced protein 3 |
Aliases | OTUD7C; TNFA1P2; OTU domain-containing protein 7C; TNF alpha-induced protein 3; putative DNA-binding protein ...... |
Chromosomal Location | 6q23-q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TNFAIP3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TNFAIP3 |
Name | tumor necrosis factor, alpha-induced protein 3 |
Aliases | OTUD7C; TNFA1P2; OTU domain-containing protein 7C; TNF alpha-induced protein 3; putative DNA-binding protein ...... |
Chromosomal Location | 6q23-q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TNFAIP3 in various data sets.
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Points in the above scatter plot represent the mutation difference of TNFAIP3 in various data sets.
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Summary | |
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Symbol | TNFAIP3 |
Name | tumor necrosis factor, alpha-induced protein 3 |
Aliases | OTUD7C; TNFA1P2; OTU domain-containing protein 7C; TNF alpha-induced protein 3; putative DNA-binding protein ...... |
Chromosomal Location | 6q23-q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TNFAIP3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | TNFAIP3 |
Name | tumor necrosis factor, alpha-induced protein 3 |
Aliases | OTUD7C; TNFA1P2; OTU domain-containing protein 7C; TNF alpha-induced protein 3; putative DNA-binding protein ...... |
Chromosomal Location | 6q23-q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TNFAIP3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TNFAIP3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TNFAIP3 |
Name | tumor necrosis factor, alpha-induced protein 3 |
Aliases | OTUD7C; TNFA1P2; OTU domain-containing protein 7C; TNF alpha-induced protein 3; putative DNA-binding protein ...... |
Chromosomal Location | 6q23-q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TNFAIP3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | TNFAIP3 |
Name | tumor necrosis factor, alpha-induced protein 3 |
Aliases | OTUD7C; TNFA1P2; OTU domain-containing protein 7C; TNF alpha-induced protein 3; putative DNA-binding protein ...... |
Chromosomal Location | 6q23-q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TNFAIP3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | TNFAIP3 |
Name | tumor necrosis factor, alpha-induced protein 3 |
Aliases | OTUD7C; TNFA1P2; OTU domain-containing protein 7C; TNF alpha-induced protein 3; putative DNA-binding protein ...... |
Chromosomal Location | 6q23-q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TNFAIP3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | TNFAIP3 |
Name | tumor necrosis factor, alpha-induced protein 3 |
Aliases | OTUD7C; TNFA1P2; OTU domain-containing protein 7C; TNF alpha-induced protein 3; putative DNA-binding protein ...... |
Chromosomal Location | 6q23-q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TNFAIP3 collected from DrugBank database. |
There is no record. |