Summary | |
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Symbol | TNFRSF10B |
Name | tumor necrosis factor receptor superfamily, member 10b |
Aliases | DR5; KILLER; TRICK2A; TRAIL-R2; TRICKB; CD262; KILLER/DR5; TRAILR2; TRICK2; TRICK2B; ZTNFR9; Fas-like protei ...... |
Chromosomal Location | 8p22-p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Domain |
PF00531 Death domain PF00020 TNFR/NGFR cysteine-rich region |
Function |
Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. |
Biological Process |
GO:0002237 response to molecule of bacterial origin GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0007249 I-kappaB kinase/NF-kappaB signaling GO:0007250 activation of NF-kappaB-inducing kinase activity GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors GO:0009612 response to mechanical stimulus GO:0010950 positive regulation of endopeptidase activity GO:0010952 positive regulation of peptidase activity GO:0032147 activation of protein kinase activity GO:0032496 response to lipopolysaccharide GO:0033209 tumor necrosis factor-mediated signaling pathway GO:0033674 positive regulation of kinase activity GO:0034612 response to tumor necrosis factor GO:0034976 response to endoplasmic reticulum stress GO:0038061 NIK/NF-kappaB signaling GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0045860 positive regulation of protein kinase activity GO:0045862 positive regulation of proteolysis GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0071214 cellular response to abiotic stimulus GO:0071260 cellular response to mechanical stimulus GO:0071356 cellular response to tumor necrosis factor GO:0071496 cellular response to external stimulus GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:0097191 extrinsic apoptotic signaling pathway GO:0097193 intrinsic apoptotic signaling pathway GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:1901222 regulation of NIK/NF-kappaB signaling GO:1901224 positive regulation of NIK/NF-kappaB signaling GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:2000116 regulation of cysteine-type endopeptidase activity GO:2001056 positive regulation of cysteine-type endopeptidase activity GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001235 positive regulation of apoptotic signaling pathway GO:2001236 regulation of extrinsic apoptotic signaling pathway GO:2001237 negative regulation of extrinsic apoptotic signaling pathway GO:2001267 regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
Molecular Function |
GO:0005031 tumor necrosis factor-activated receptor activity GO:0005035 death receptor activity GO:0045569 TRAIL binding |
Cellular Component | - |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction hsa04115 p53 signaling pathway hsa04210 Apoptosis hsa04650 Natural killer cell mediated cytotoxicity |
Reactome |
R-HSA-109581: Apoptosis R-HSA-5218900: CASP8 activity is inhibited R-HSA-5357769: Caspase activation via extrinsic apoptotic signalling pathway R-HSA-202733: Cell surface interactions at the vascular wall R-HSA-73887: Death Receptor Signalling R-HSA-69416: Dimerization of procaspase-8 R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-109582: Hemostasis R-HSA-140534: Ligand-dependent caspase activation R-HSA-5357801: Programmed Cell Death R-HSA-5213460: RIPK1-mediated regulated necrosis R-HSA-5218859: Regulated Necrosis R-HSA-3371378: Regulation by c-FLIP R-HSA-5675482: Regulation of necroptotic cell death R-HSA-162582: Signal Transduction R-HSA-5633008: TP53 Regulates Transcription of Cell Death Genes R-HSA-6803211: TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-75158: TRAIL signaling R-HSA-3700989: Transcriptional Regulation by TP53 |
Summary | |
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Symbol | TNFRSF10B |
Name | tumor necrosis factor receptor superfamily, member 10b |
Aliases | DR5; KILLER; TRICK2A; TRAIL-R2; TRICKB; CD262; KILLER/DR5; TRAILR2; TRICK2; TRICK2B; ZTNFR9; Fas-like protei ...... |
Chromosomal Location | 8p22-p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TNFRSF10B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between TNFRSF10B and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | TNFRSF10B |
Name | tumor necrosis factor receptor superfamily, member 10b |
Aliases | DR5; KILLER; TRICK2A; TRAIL-R2; TRICKB; CD262; KILLER/DR5; TRAILR2; TRICK2; TRICK2B; ZTNFR9; Fas-like protei ...... |
Chromosomal Location | 8p22-p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TNFRSF10B in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TNFRSF10B |
Name | tumor necrosis factor receptor superfamily, member 10b |
Aliases | DR5; KILLER; TRICK2A; TRAIL-R2; TRICKB; CD262; KILLER/DR5; TRAILR2; TRICK2; TRICK2B; ZTNFR9; Fas-like protei ...... |
Chromosomal Location | 8p22-p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TNFRSF10B in various data sets.
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Points in the above scatter plot represent the mutation difference of TNFRSF10B in various data sets.
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Summary | |
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Symbol | TNFRSF10B |
Name | tumor necrosis factor receptor superfamily, member 10b |
Aliases | DR5; KILLER; TRICK2A; TRAIL-R2; TRICKB; CD262; KILLER/DR5; TRAILR2; TRICK2; TRICK2B; ZTNFR9; Fas-like protei ...... |
Chromosomal Location | 8p22-p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TNFRSF10B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | TNFRSF10B |
Name | tumor necrosis factor receptor superfamily, member 10b |
Aliases | DR5; KILLER; TRICK2A; TRAIL-R2; TRICKB; CD262; KILLER/DR5; TRAILR2; TRICK2; TRICK2B; ZTNFR9; Fas-like protei ...... |
Chromosomal Location | 8p22-p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TNFRSF10B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TNFRSF10B. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TNFRSF10B |
Name | tumor necrosis factor receptor superfamily, member 10b |
Aliases | DR5; KILLER; TRICK2A; TRAIL-R2; TRICKB; CD262; KILLER/DR5; TRAILR2; TRICK2; TRICK2B; ZTNFR9; Fas-like protei ...... |
Chromosomal Location | 8p22-p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TNFRSF10B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | TNFRSF10B |
Name | tumor necrosis factor receptor superfamily, member 10b |
Aliases | DR5; KILLER; TRICK2A; TRAIL-R2; TRICKB; CD262; KILLER/DR5; TRAILR2; TRICK2; TRICK2B; ZTNFR9; Fas-like protei ...... |
Chromosomal Location | 8p22-p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TNFRSF10B expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | TNFRSF10B |
Name | tumor necrosis factor receptor superfamily, member 10b |
Aliases | DR5; KILLER; TRICK2A; TRAIL-R2; TRICKB; CD262; KILLER/DR5; TRAILR2; TRICK2; TRICK2B; ZTNFR9; Fas-like protei ...... |
Chromosomal Location | 8p22-p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TNFRSF10B and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | TNFRSF10B |
Name | tumor necrosis factor receptor superfamily, member 10b |
Aliases | DR5; KILLER; TRICK2A; TRAIL-R2; TRICKB; CD262; KILLER/DR5; TRAILR2; TRICK2; TRICK2B; ZTNFR9; Fas-like protei ...... |
Chromosomal Location | 8p22-p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TNFRSF10B collected from DrugBank database. |
Details on drugs targeting TNFRSF10B.
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