Browse TNFRSF12A

Summary
SymbolTNFRSF12A
Nametumor necrosis factor receptor superfamily, member 12A
Aliases FN14; TweakR; CD266; FGF-inducible 14; fibroblast growth factor-inducible immediate-early response protein 1 ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Membrane; Single-pass type I membrane protein.
Domain PF12191 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain
Function

Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.

> Gene Ontology
 
Biological Process GO:0001525 angiogenesis
GO:0001558 regulation of cell growth
GO:0006929 substrate-dependent cell migration
GO:0006931 substrate-dependent cell migration, cell attachment to substrate
GO:0007409 axonogenesis
GO:0008361 regulation of cell size
GO:0010720 positive regulation of cell development
GO:0010769 regulation of cell morphogenesis involved in differentiation
GO:0010770 positive regulation of cell morphogenesis involved in differentiation
GO:0010975 regulation of neuron projection development
GO:0010976 positive regulation of neuron projection development
GO:0016049 cell growth
GO:0022604 regulation of cell morphogenesis
GO:0030307 positive regulation of cell growth
GO:0030516 regulation of axon extension
GO:0031346 positive regulation of cell projection organization
GO:0031589 cell-substrate adhesion
GO:0032535 regulation of cellular component size
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0034612 response to tumor necrosis factor
GO:0045666 positive regulation of neuron differentiation
GO:0045765 regulation of angiogenesis
GO:0045773 positive regulation of axon extension
GO:0045927 positive regulation of growth
GO:0048514 blood vessel morphogenesis
GO:0048588 developmental cell growth
GO:0048638 regulation of developmental growth
GO:0048639 positive regulation of developmental growth
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048675 axon extension
GO:0050769 positive regulation of neurogenesis
GO:0050770 regulation of axonogenesis
GO:0050772 positive regulation of axonogenesis
GO:0051962 positive regulation of nervous system development
GO:0060560 developmental growth involved in morphogenesis
GO:0061041 regulation of wound healing
GO:0061387 regulation of extent of cell growth
GO:0061564 axon development
GO:0071356 cellular response to tumor necrosis factor
GO:0090066 regulation of anatomical structure size
GO:0097191 extrinsic apoptotic signaling pathway
GO:1901342 regulation of vasculature development
GO:1903034 regulation of response to wounding
GO:1990138 neuron projection extension
GO:2001233 regulation of apoptotic signaling pathway
GO:2001235 positive regulation of apoptotic signaling pathway
GO:2001236 regulation of extrinsic apoptotic signaling pathway
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
Molecular Function -
Cellular Component GO:0001726 ruffle
GO:0031252 cell leading edge
> KEGG and Reactome Pathway
 
KEGG hsa04060 Cytokine-cytokine receptor interaction
Reactome R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-168256: Immune System
R-HSA-5676594: TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
R-HSA-5668541: TNFR2 non-canonical NF-kB pathway
Summary
SymbolTNFRSF12A
Nametumor necrosis factor receptor superfamily, member 12A
Aliases FN14; TweakR; CD266; FGF-inducible 14; fibroblast growth factor-inducible immediate-early response protein 1 ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between TNFRSF12A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolTNFRSF12A
Nametumor necrosis factor receptor superfamily, member 12A
Aliases FN14; TweakR; CD266; FGF-inducible 14; fibroblast growth factor-inducible immediate-early response protein 1 ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of TNFRSF12A in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 STARS Score: 3.96; FDR: 0.032 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolTNFRSF12A
Nametumor necrosis factor receptor superfamily, member 12A
Aliases FN14; TweakR; CD266; FGF-inducible 14; fibroblast growth factor-inducible immediate-early response protein 1 ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of TNFRSF12A in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.250.664
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.1660.957
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2910.884
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.2760.668
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.4870.786
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.0150.994
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.2840.6
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.7730.546
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.3040.821
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.6530.776
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.5630.871
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.3560.0228
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of TNFRSF12A in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolTNFRSF12A
Nametumor necrosis factor receptor superfamily, member 12A
Aliases FN14; TweakR; CD266; FGF-inducible 14; fibroblast growth factor-inducible immediate-early response protein 1 ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TNFRSF12A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolTNFRSF12A
Nametumor necrosis factor receptor superfamily, member 12A
Aliases FN14; TweakR; CD266; FGF-inducible 14; fibroblast growth factor-inducible immediate-early response protein 1 ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TNFRSF12A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TNFRSF12A.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolTNFRSF12A
Nametumor necrosis factor receptor superfamily, member 12A
Aliases FN14; TweakR; CD266; FGF-inducible 14; fibroblast growth factor-inducible immediate-early response protein 1 ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TNFRSF12A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolTNFRSF12A
Nametumor necrosis factor receptor superfamily, member 12A
Aliases FN14; TweakR; CD266; FGF-inducible 14; fibroblast growth factor-inducible immediate-early response protein 1 ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of TNFRSF12A expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolTNFRSF12A
Nametumor necrosis factor receptor superfamily, member 12A
Aliases FN14; TweakR; CD266; FGF-inducible 14; fibroblast growth factor-inducible immediate-early response protein 1 ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between TNFRSF12A and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolTNFRSF12A
Nametumor necrosis factor receptor superfamily, member 12A
Aliases FN14; TweakR; CD266; FGF-inducible 14; fibroblast growth factor-inducible immediate-early response protein 1 ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting TNFRSF12A collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.