Summary | |
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Symbol | TNFRSF14 |
Name | tumor necrosis factor receptor superfamily, member 14 |
Aliases | HVEM; ATAR; LIGHTR; HVEA; CD270; herpesvirus entry mediator; tumor necrosis factor receptor superfamily, mem ...... |
Chromosomal Location | 1p36.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Single-pass type I membrane protein |
Domain |
PF00020 TNFR/NGFR cysteine-rich region |
Function |
Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells. ; FUNCTION: (Microbial infection) Acts as a receptor for Herpes simplex virus 1/HHV-1. ; FUNCTION: (Microbial infection) Acts as a receptor for Herpes simplex virus 2/HHV-2. |
Biological Process |
GO:0001819 positive regulation of cytokine production GO:0002237 response to molecule of bacterial origin GO:0002367 cytokine production involved in immune response GO:0002374 cytokine secretion involved in immune response GO:0002440 production of molecular mediator of immune response GO:0002683 negative regulation of immune system process GO:0002685 regulation of leukocyte migration GO:0002687 positive regulation of leukocyte migration GO:0002694 regulation of leukocyte activation GO:0002695 negative regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002697 regulation of immune effector process GO:0002699 positive regulation of immune effector process GO:0002700 regulation of production of molecular mediator of immune response GO:0002702 positive regulation of production of molecular mediator of immune response GO:0002718 regulation of cytokine production involved in immune response GO:0002720 positive regulation of cytokine production involved in immune response GO:0002739 regulation of cytokine secretion involved in immune response GO:0002741 positive regulation of cytokine secretion involved in immune response GO:0007159 leukocyte cell-cell adhesion GO:0007162 negative regulation of cell adhesion GO:0009306 protein secretion GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0019058 viral life cycle GO:0022407 regulation of cell-cell adhesion GO:0022408 negative regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0030260 entry into host cell GO:0030335 positive regulation of cell migration GO:0031294 lymphocyte costimulation GO:0031295 T cell costimulation GO:0032496 response to lipopolysaccharide GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0032945 negative regulation of mononuclear cell proliferation GO:0033209 tumor necrosis factor-mediated signaling pathway GO:0034612 response to tumor necrosis factor GO:0040017 positive regulation of locomotion GO:0042098 T cell proliferation GO:0042110 T cell activation GO:0042129 regulation of T cell proliferation GO:0042130 negative regulation of T cell proliferation GO:0042742 defense response to bacterium GO:0043410 positive regulation of MAPK cascade GO:0044409 entry into host GO:0045785 positive regulation of cell adhesion GO:0046631 alpha-beta T cell activation GO:0046633 alpha-beta T cell proliferation GO:0046634 regulation of alpha-beta T cell activation GO:0046636 negative regulation of alpha-beta T cell activation GO:0046640 regulation of alpha-beta T cell proliferation GO:0046642 negative regulation of alpha-beta T cell proliferation GO:0046651 lymphocyte proliferation GO:0046718 viral entry into host cell GO:0050663 cytokine secretion GO:0050670 regulation of lymphocyte proliferation GO:0050672 negative regulation of lymphocyte proliferation GO:0050707 regulation of cytokine secretion GO:0050708 regulation of protein secretion GO:0050714 positive regulation of protein secretion GO:0050715 positive regulation of cytokine secretion GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050829 defense response to Gram-negative bacterium GO:0050830 defense response to Gram-positive bacterium GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050866 negative regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050868 negative regulation of T cell activation GO:0050870 positive regulation of T cell activation GO:0050900 leukocyte migration GO:0051047 positive regulation of secretion GO:0051222 positive regulation of protein transport GO:0051249 regulation of lymphocyte activation GO:0051250 negative regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051272 positive regulation of cellular component movement GO:0051701 interaction with host GO:0051806 entry into cell of other organism involved in symbiotic interaction GO:0051828 entry into other organism involved in symbiotic interaction GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0070664 negative regulation of leukocyte proliferation GO:0071356 cellular response to tumor necrosis factor GO:0071593 lymphocyte aggregation GO:0072676 lymphocyte migration GO:0072678 T cell migration GO:0098542 defense response to other organism GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903038 negative regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903532 positive regulation of secretion by cell GO:1904951 positive regulation of establishment of protein localization GO:2000147 positive regulation of cell motility GO:2000401 regulation of lymphocyte migration GO:2000403 positive regulation of lymphocyte migration GO:2000404 regulation of T cell migration GO:2000406 positive regulation of T cell migration |
Molecular Function |
GO:0001618 virus receptor activity GO:0005031 tumor necrosis factor-activated receptor activity GO:0005035 death receptor activity GO:0031625 ubiquitin protein ligase binding GO:0044389 ubiquitin-like protein ligase binding |
Cellular Component |
GO:0009897 external side of plasma membrane GO:0098552 side of membrane |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-388841: Costimulation by the CD28 family R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-5668541: TNFR2 non-canonical NF-kB pathway R-HSA-5669034: TNFs bind their physiological receptors |
Summary | |
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Symbol | TNFRSF14 |
Name | tumor necrosis factor receptor superfamily, member 14 |
Aliases | HVEM; ATAR; LIGHTR; HVEA; CD270; herpesvirus entry mediator; tumor necrosis factor receptor superfamily, mem ...... |
Chromosomal Location | 1p36.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TNFRSF14 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between TNFRSF14 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | TNFRSF14 |
Name | tumor necrosis factor receptor superfamily, member 14 |
Aliases | HVEM; ATAR; LIGHTR; HVEA; CD270; herpesvirus entry mediator; tumor necrosis factor receptor superfamily, mem ...... |
Chromosomal Location | 1p36.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TNFRSF14 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TNFRSF14 |
Name | tumor necrosis factor receptor superfamily, member 14 |
Aliases | HVEM; ATAR; LIGHTR; HVEA; CD270; herpesvirus entry mediator; tumor necrosis factor receptor superfamily, mem ...... |
Chromosomal Location | 1p36.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TNFRSF14 in various data sets.
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Points in the above scatter plot represent the mutation difference of TNFRSF14 in various data sets.
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Summary | |
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Symbol | TNFRSF14 |
Name | tumor necrosis factor receptor superfamily, member 14 |
Aliases | HVEM; ATAR; LIGHTR; HVEA; CD270; herpesvirus entry mediator; tumor necrosis factor receptor superfamily, mem ...... |
Chromosomal Location | 1p36.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TNFRSF14. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | TNFRSF14 |
Name | tumor necrosis factor receptor superfamily, member 14 |
Aliases | HVEM; ATAR; LIGHTR; HVEA; CD270; herpesvirus entry mediator; tumor necrosis factor receptor superfamily, mem ...... |
Chromosomal Location | 1p36.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TNFRSF14. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TNFRSF14. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TNFRSF14 |
Name | tumor necrosis factor receptor superfamily, member 14 |
Aliases | HVEM; ATAR; LIGHTR; HVEA; CD270; herpesvirus entry mediator; tumor necrosis factor receptor superfamily, mem ...... |
Chromosomal Location | 1p36.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TNFRSF14. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TNFRSF14 |
Name | tumor necrosis factor receptor superfamily, member 14 |
Aliases | HVEM; ATAR; LIGHTR; HVEA; CD270; herpesvirus entry mediator; tumor necrosis factor receptor superfamily, mem ...... |
Chromosomal Location | 1p36.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TNFRSF14 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TNFRSF14 |
Name | tumor necrosis factor receptor superfamily, member 14 |
Aliases | HVEM; ATAR; LIGHTR; HVEA; CD270; herpesvirus entry mediator; tumor necrosis factor receptor superfamily, mem ...... |
Chromosomal Location | 1p36.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TNFRSF14 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | TNFRSF14 |
Name | tumor necrosis factor receptor superfamily, member 14 |
Aliases | HVEM; ATAR; LIGHTR; HVEA; CD270; herpesvirus entry mediator; tumor necrosis factor receptor superfamily, mem ...... |
Chromosomal Location | 1p36.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TNFRSF14 collected from DrugBank database. |
There is no record. |