Summary | |
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Symbol | TNFRSF8 |
Name | tumor necrosis factor receptor superfamily, member 8 |
Aliases | KI-1; CD30; D1S166E; CD30L receptor; Ki-1 antigen; cytokine receptor CD30; lymphocyte activation antigen CD3 ...... |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Isoform 1: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm. |
Domain |
PF00020 TNFR/NGFR cysteine-rich region |
Function |
Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B. |
Biological Process |
GO:0001819 positive regulation of cytokine production GO:0002237 response to molecule of bacterial origin GO:0009612 response to mechanical stimulus GO:0032496 response to lipopolysaccharide GO:0032639 TRAIL production GO:0032640 tumor necrosis factor production GO:0032679 regulation of TRAIL production GO:0032680 regulation of tumor necrosis factor production GO:0032759 positive regulation of TRAIL production GO:0032760 positive regulation of tumor necrosis factor production GO:0033209 tumor necrosis factor-mediated signaling pathway GO:0034612 response to tumor necrosis factor GO:0042035 regulation of cytokine biosynthetic process GO:0042089 cytokine biosynthetic process GO:0042107 cytokine metabolic process GO:0042108 positive regulation of cytokine biosynthetic process GO:0042533 tumor necrosis factor biosynthetic process GO:0042534 regulation of tumor necrosis factor biosynthetic process GO:0042535 positive regulation of tumor necrosis factor biosynthetic process GO:0045553 TRAIL biosynthetic process GO:0045554 regulation of TRAIL biosynthetic process GO:0045556 positive regulation of TRAIL biosynthetic process GO:0071214 cellular response to abiotic stimulus GO:0071260 cellular response to mechanical stimulus GO:0071356 cellular response to tumor necrosis factor GO:0071496 cellular response to external stimulus GO:0071706 tumor necrosis factor superfamily cytokine production GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production |
Molecular Function |
GO:0005031 tumor necrosis factor-activated receptor activity GO:0005035 death receptor activity |
Cellular Component | - |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-5668541: TNFR2 non-canonical NF-kB pathway R-HSA-5669034: TNFs bind their physiological receptors |
Summary | |
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Symbol | TNFRSF8 |
Name | tumor necrosis factor receptor superfamily, member 8 |
Aliases | KI-1; CD30; D1S166E; CD30L receptor; Ki-1 antigen; cytokine receptor CD30; lymphocyte activation antigen CD3 ...... |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TNFRSF8 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between TNFRSF8 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | TNFRSF8 |
Name | tumor necrosis factor receptor superfamily, member 8 |
Aliases | KI-1; CD30; D1S166E; CD30L receptor; Ki-1 antigen; cytokine receptor CD30; lymphocyte activation antigen CD3 ...... |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TNFRSF8 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TNFRSF8 |
Name | tumor necrosis factor receptor superfamily, member 8 |
Aliases | KI-1; CD30; D1S166E; CD30L receptor; Ki-1 antigen; cytokine receptor CD30; lymphocyte activation antigen CD3 ...... |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TNFRSF8 in various data sets.
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Points in the above scatter plot represent the mutation difference of TNFRSF8 in various data sets.
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Summary | |
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Symbol | TNFRSF8 |
Name | tumor necrosis factor receptor superfamily, member 8 |
Aliases | KI-1; CD30; D1S166E; CD30L receptor; Ki-1 antigen; cytokine receptor CD30; lymphocyte activation antigen CD3 ...... |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TNFRSF8. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | TNFRSF8 |
Name | tumor necrosis factor receptor superfamily, member 8 |
Aliases | KI-1; CD30; D1S166E; CD30L receptor; Ki-1 antigen; cytokine receptor CD30; lymphocyte activation antigen CD3 ...... |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TNFRSF8. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TNFRSF8. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TNFRSF8 |
Name | tumor necrosis factor receptor superfamily, member 8 |
Aliases | KI-1; CD30; D1S166E; CD30L receptor; Ki-1 antigen; cytokine receptor CD30; lymphocyte activation antigen CD3 ...... |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TNFRSF8. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | TNFRSF8 |
Name | tumor necrosis factor receptor superfamily, member 8 |
Aliases | KI-1; CD30; D1S166E; CD30L receptor; Ki-1 antigen; cytokine receptor CD30; lymphocyte activation antigen CD3 ...... |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TNFRSF8 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | TNFRSF8 |
Name | tumor necrosis factor receptor superfamily, member 8 |
Aliases | KI-1; CD30; D1S166E; CD30L receptor; Ki-1 antigen; cytokine receptor CD30; lymphocyte activation antigen CD3 ...... |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TNFRSF8 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | TNFRSF8 |
Name | tumor necrosis factor receptor superfamily, member 8 |
Aliases | KI-1; CD30; D1S166E; CD30L receptor; Ki-1 antigen; cytokine receptor CD30; lymphocyte activation antigen CD3 ...... |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TNFRSF8 collected from DrugBank database. |
Details on drugs targeting TNFRSF8.
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