Summary | |
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Symbol | TNFSF13B |
Name | tumor necrosis factor (ligand) superfamily, member 13b |
Aliases | BAFF; THANK; BLYS; TALL-1; TALL1; CD257; TNFSF20; ZTNF4; ApoL related ligand TALL-1; B-cell-activating facto ...... |
Chromosomal Location | 13q32-q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Single-pass type II membrane protein.; SUBCELLULAR LOCATION: Tumor necrosis factor ligand superfamily member 13b, soluble form: Secreted. |
Domain |
PF00229 TNF(Tumour Necrosis Factor) family |
Function |
Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. ; FUNCTION: Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. ; FUNCTION: Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis. |
Biological Process |
GO:0001776 leukocyte homeostasis GO:0001782 B cell homeostasis GO:0002250 adaptive immune response GO:0002260 lymphocyte homeostasis GO:0002377 immunoglobulin production GO:0002440 production of molecular mediator of immune response GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002467 germinal center formation GO:0002634 regulation of germinal center formation GO:0002636 positive regulation of germinal center formation GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002819 regulation of adaptive immune response GO:0002821 positive regulation of adaptive immune response GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0007159 leukocyte cell-cell adhesion GO:0009306 protein secretion GO:0022407 regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0030888 regulation of B cell proliferation GO:0030890 positive regulation of B cell proliferation GO:0031294 lymphocyte costimulation GO:0031295 T cell costimulation GO:0031296 B cell costimulation GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0032946 positive regulation of mononuclear cell proliferation GO:0033209 tumor necrosis factor-mediated signaling pathway GO:0034612 response to tumor necrosis factor GO:0042098 T cell proliferation GO:0042100 B cell proliferation GO:0042102 positive regulation of T cell proliferation GO:0042110 T cell activation GO:0042113 B cell activation GO:0042129 regulation of T cell proliferation GO:0045785 positive regulation of cell adhesion GO:0046651 lymphocyte proliferation GO:0048305 immunoglobulin secretion GO:0048872 homeostasis of number of cells GO:0050670 regulation of lymphocyte proliferation GO:0050671 positive regulation of lymphocyte proliferation GO:0050863 regulation of T cell activation GO:0050864 regulation of B cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050870 positive regulation of T cell activation GO:0050871 positive regulation of B cell activation GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0070665 positive regulation of leukocyte proliferation GO:0071356 cellular response to tumor necrosis factor GO:0071593 lymphocyte aggregation GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion |
Molecular Function |
GO:0005125 cytokine activity GO:0005126 cytokine receptor binding GO:0005164 tumor necrosis factor receptor binding GO:0032813 tumor necrosis factor receptor superfamily binding |
Cellular Component | - |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction hsa04064 NF-kappa B signaling pathway hsa04672 Intestinal immune network for IgA production |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-5676594: TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5668541: TNFR2 non-canonical NF-kB pathway R-HSA-5669034: TNFs bind their physiological receptors |
Summary | |
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Symbol | TNFSF13B |
Name | tumor necrosis factor (ligand) superfamily, member 13b |
Aliases | BAFF; THANK; BLYS; TALL-1; TALL1; CD257; TNFSF20; ZTNF4; ApoL related ligand TALL-1; B-cell-activating facto ...... |
Chromosomal Location | 13q32-q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TNFSF13B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between TNFSF13B and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | TNFSF13B |
Name | tumor necrosis factor (ligand) superfamily, member 13b |
Aliases | BAFF; THANK; BLYS; TALL-1; TALL1; CD257; TNFSF20; ZTNF4; ApoL related ligand TALL-1; B-cell-activating facto ...... |
Chromosomal Location | 13q32-q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TNFSF13B in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TNFSF13B |
Name | tumor necrosis factor (ligand) superfamily, member 13b |
Aliases | BAFF; THANK; BLYS; TALL-1; TALL1; CD257; TNFSF20; ZTNF4; ApoL related ligand TALL-1; B-cell-activating facto ...... |
Chromosomal Location | 13q32-q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TNFSF13B in various data sets.
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Points in the above scatter plot represent the mutation difference of TNFSF13B in various data sets.
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Summary | |
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Symbol | TNFSF13B |
Name | tumor necrosis factor (ligand) superfamily, member 13b |
Aliases | BAFF; THANK; BLYS; TALL-1; TALL1; CD257; TNFSF20; ZTNF4; ApoL related ligand TALL-1; B-cell-activating facto ...... |
Chromosomal Location | 13q32-q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TNFSF13B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | TNFSF13B |
Name | tumor necrosis factor (ligand) superfamily, member 13b |
Aliases | BAFF; THANK; BLYS; TALL-1; TALL1; CD257; TNFSF20; ZTNF4; ApoL related ligand TALL-1; B-cell-activating facto ...... |
Chromosomal Location | 13q32-q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TNFSF13B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TNFSF13B. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TNFSF13B |
Name | tumor necrosis factor (ligand) superfamily, member 13b |
Aliases | BAFF; THANK; BLYS; TALL-1; TALL1; CD257; TNFSF20; ZTNF4; ApoL related ligand TALL-1; B-cell-activating facto ...... |
Chromosomal Location | 13q32-q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TNFSF13B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | TNFSF13B |
Name | tumor necrosis factor (ligand) superfamily, member 13b |
Aliases | BAFF; THANK; BLYS; TALL-1; TALL1; CD257; TNFSF20; ZTNF4; ApoL related ligand TALL-1; B-cell-activating facto ...... |
Chromosomal Location | 13q32-q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TNFSF13B expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | TNFSF13B |
Name | tumor necrosis factor (ligand) superfamily, member 13b |
Aliases | BAFF; THANK; BLYS; TALL-1; TALL1; CD257; TNFSF20; ZTNF4; ApoL related ligand TALL-1; B-cell-activating facto ...... |
Chromosomal Location | 13q32-q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TNFSF13B and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | TNFSF13B |
Name | tumor necrosis factor (ligand) superfamily, member 13b |
Aliases | BAFF; THANK; BLYS; TALL-1; TALL1; CD257; TNFSF20; ZTNF4; ApoL related ligand TALL-1; B-cell-activating facto ...... |
Chromosomal Location | 13q32-q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TNFSF13B collected from DrugBank database. |
Details on drugs targeting TNFSF13B.
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