Summary | |
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Symbol | TNFSF14 |
Name | tumor necrosis factor (ligand) superfamily, member 14 |
Aliases | LIGHT; LTg; HVEM-L; CD258; HVEML; delta transmembrane LIGHT; herpes virus entry mediator ligand; herpesvirus ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Tumor necrosis factor ligand superfamily member 14, membrane form: Cell membrane; Single-pass type II membrane protein.; SUBCELLULAR LOCATION: Tumor necrosis factor ligand superfamily member 14, soluble form: Secreted.; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm. |
Domain |
PF00229 TNF(Tumour Necrosis Factor) family |
Function |
Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus. |
Biological Process |
GO:0000768 syncytium formation by plasma membrane fusion GO:0001776 leukocyte homeostasis GO:0002260 lymphocyte homeostasis GO:0002685 regulation of leukocyte migration GO:0002687 positive regulation of leukocyte migration GO:0002688 regulation of leukocyte chemotaxis GO:0002690 positive regulation of leukocyte chemotaxis GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0006606 protein import into nucleus GO:0006913 nucleocytoplasmic transport GO:0006949 syncytium formation GO:0007159 leukocyte cell-cell adhesion GO:0007249 I-kappaB kinase/NF-kappaB signaling GO:0007253 cytoplasmic sequestering of NF-kappaB GO:0007520 myoblast fusion GO:0008588 release of cytoplasmic sequestered NF-kappaB GO:0009612 response to mechanical stimulus GO:0010466 negative regulation of peptidase activity GO:0010818 T cell chemotaxis GO:0010819 regulation of T cell chemotaxis GO:0010820 positive regulation of T cell chemotaxis GO:0010830 regulation of myotube differentiation GO:0010831 positive regulation of myotube differentiation GO:0010951 negative regulation of endopeptidase activity GO:0014902 myotube differentiation GO:0017038 protein import GO:0022407 regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0030335 positive regulation of cell migration GO:0030595 leukocyte chemotaxis GO:0031294 lymphocyte costimulation GO:0031295 T cell costimulation GO:0031503 protein complex localization GO:0032103 positive regulation of response to external stimulus GO:0032386 regulation of intracellular transport GO:0032387 negative regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0032507 maintenance of protein location in cell GO:0032943 mononuclear cell proliferation GO:0033157 regulation of intracellular protein transport GO:0033209 tumor necrosis factor-mediated signaling pathway GO:0034504 protein localization to nucleus GO:0034612 response to tumor necrosis factor GO:0040017 positive regulation of locomotion GO:0042098 T cell proliferation GO:0042110 T cell activation GO:0042306 regulation of protein import into nucleus GO:0042307 positive regulation of protein import into nucleus GO:0042308 negative regulation of protein import into nucleus GO:0042345 regulation of NF-kappaB import into nucleus GO:0042346 positive regulation of NF-kappaB import into nucleus GO:0042347 negative regulation of NF-kappaB import into nucleus GO:0042348 NF-kappaB import into nucleus GO:0042692 muscle cell differentiation GO:0042990 regulation of transcription factor import into nucleus GO:0042991 transcription factor import into nucleus GO:0042992 negative regulation of transcription factor import into nucleus GO:0042993 positive regulation of transcription factor import into nucleus GO:0042994 cytoplasmic sequestering of transcription factor GO:0043029 T cell homeostasis GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0044744 protein targeting to nucleus GO:0045185 maintenance of protein location GO:0045445 myoblast differentiation GO:0045661 regulation of myoblast differentiation GO:0045663 positive regulation of myoblast differentiation GO:0045785 positive regulation of cell adhesion GO:0045861 negative regulation of proteolysis GO:0046651 lymphocyte proliferation GO:0046822 regulation of nucleocytoplasmic transport GO:0046823 negative regulation of nucleocytoplasmic transport GO:0046824 positive regulation of nucleocytoplasmic transport GO:0048247 lymphocyte chemotaxis GO:0048872 homeostasis of number of cells GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050870 positive regulation of T cell activation GO:0050900 leukocyte migration GO:0050920 regulation of chemotaxis GO:0050921 positive regulation of chemotaxis GO:0051051 negative regulation of transport GO:0051146 striated muscle cell differentiation GO:0051147 regulation of muscle cell differentiation GO:0051149 positive regulation of muscle cell differentiation GO:0051153 regulation of striated muscle cell differentiation GO:0051155 positive regulation of striated muscle cell differentiation GO:0051169 nuclear transport GO:0051170 nuclear import GO:0051220 cytoplasmic sequestering of protein GO:0051222 positive regulation of protein transport GO:0051224 negative regulation of protein transport GO:0051235 maintenance of location GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051272 positive regulation of cellular component movement GO:0051346 negative regulation of hydrolase activity GO:0051651 maintenance of location in cell GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0060142 regulation of syncytium formation by plasma membrane fusion GO:0060143 positive regulation of syncytium formation by plasma membrane fusion GO:0060326 cell chemotaxis GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070661 leukocyte proliferation GO:0071214 cellular response to abiotic stimulus GO:0071260 cellular response to mechanical stimulus GO:0071356 cellular response to tumor necrosis factor GO:0071496 cellular response to external stimulus GO:0071593 lymphocyte aggregation GO:0072676 lymphocyte migration GO:0072678 T cell migration GO:0090316 positive regulation of intracellular protein transport GO:0090317 negative regulation of intracellular protein transport GO:1900180 regulation of protein localization to nucleus GO:1900181 negative regulation of protein localization to nucleus GO:1900182 positive regulation of protein localization to nucleus GO:1901623 regulation of lymphocyte chemotaxis GO:1901739 regulation of myoblast fusion GO:1901741 positive regulation of myoblast fusion GO:1902532 negative regulation of intracellular signal transduction GO:1902593 single-organism nuclear import GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903533 regulation of protein targeting GO:1903828 negative regulation of cellular protein localization GO:1903829 positive regulation of cellular protein localization GO:1904589 regulation of protein import GO:1904590 negative regulation of protein import GO:1904591 positive regulation of protein import GO:1904950 negative regulation of establishment of protein localization GO:1904951 positive regulation of establishment of protein localization GO:2000116 regulation of cysteine-type endopeptidase activity GO:2000117 negative regulation of cysteine-type endopeptidase activity GO:2000147 positive regulation of cell motility GO:2000401 regulation of lymphocyte migration GO:2000403 positive regulation of lymphocyte migration GO:2000404 regulation of T cell migration GO:2000406 positive regulation of T cell migration |
Molecular Function |
GO:0004857 enzyme inhibitor activity GO:0004866 endopeptidase inhibitor activity GO:0004869 cysteine-type endopeptidase inhibitor activity GO:0005125 cytokine activity GO:0005126 cytokine receptor binding GO:0005164 tumor necrosis factor receptor binding GO:0030414 peptidase inhibitor activity GO:0032813 tumor necrosis factor receptor superfamily binding GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process GO:0061134 peptidase regulator activity GO:0061135 endopeptidase regulator activity |
Cellular Component | - |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction hsa04064 NF-kappa B signaling pathway |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-5676594: TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5668541: TNFR2 non-canonical NF-kB pathway R-HSA-5669034: TNFs bind their physiological receptors |
Summary | |
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Symbol | TNFSF14 |
Name | tumor necrosis factor (ligand) superfamily, member 14 |
Aliases | LIGHT; LTg; HVEM-L; CD258; HVEML; delta transmembrane LIGHT; herpes virus entry mediator ligand; herpesvirus ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TNFSF14 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between TNFSF14 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | TNFSF14 |
Name | tumor necrosis factor (ligand) superfamily, member 14 |
Aliases | LIGHT; LTg; HVEM-L; CD258; HVEML; delta transmembrane LIGHT; herpes virus entry mediator ligand; herpesvirus ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TNFSF14 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TNFSF14 |
Name | tumor necrosis factor (ligand) superfamily, member 14 |
Aliases | LIGHT; LTg; HVEM-L; CD258; HVEML; delta transmembrane LIGHT; herpes virus entry mediator ligand; herpesvirus ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TNFSF14 in various data sets.
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Points in the above scatter plot represent the mutation difference of TNFSF14 in various data sets.
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Summary | |
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Symbol | TNFSF14 |
Name | tumor necrosis factor (ligand) superfamily, member 14 |
Aliases | LIGHT; LTg; HVEM-L; CD258; HVEML; delta transmembrane LIGHT; herpes virus entry mediator ligand; herpesvirus ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TNFSF14. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | TNFSF14 |
Name | tumor necrosis factor (ligand) superfamily, member 14 |
Aliases | LIGHT; LTg; HVEM-L; CD258; HVEML; delta transmembrane LIGHT; herpes virus entry mediator ligand; herpesvirus ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TNFSF14. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TNFSF14. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TNFSF14 |
Name | tumor necrosis factor (ligand) superfamily, member 14 |
Aliases | LIGHT; LTg; HVEM-L; CD258; HVEML; delta transmembrane LIGHT; herpes virus entry mediator ligand; herpesvirus ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TNFSF14. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | TNFSF14 |
Name | tumor necrosis factor (ligand) superfamily, member 14 |
Aliases | LIGHT; LTg; HVEM-L; CD258; HVEML; delta transmembrane LIGHT; herpes virus entry mediator ligand; herpesvirus ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TNFSF14 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | TNFSF14 |
Name | tumor necrosis factor (ligand) superfamily, member 14 |
Aliases | LIGHT; LTg; HVEM-L; CD258; HVEML; delta transmembrane LIGHT; herpes virus entry mediator ligand; herpesvirus ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TNFSF14 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | TNFSF14 |
Name | tumor necrosis factor (ligand) superfamily, member 14 |
Aliases | LIGHT; LTg; HVEM-L; CD258; HVEML; delta transmembrane LIGHT; herpes virus entry mediator ligand; herpesvirus ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TNFSF14 collected from DrugBank database. |
There is no record. |