Summary | |
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Symbol | TNFSF8 |
Name | tumor necrosis factor (ligand) superfamily, member 8 |
Aliases | CD153; CD30LG; CD30L; CD153 antigen; CD30 antigen ligand; CD30 ligand; CD30-L; CD antigen CD153; Tumor necro ...... |
Chromosomal Location | 9q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane; Single-pass type II membrane protein. |
Domain |
PF00229 TNF(Tumour Necrosis Factor) family |
Function |
Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells. |
Biological Process |
GO:0002521 leukocyte differentiation GO:0007159 leukocyte cell-cell adhesion GO:0030098 lymphocyte differentiation GO:0030217 T cell differentiation GO:0036037 CD8-positive, alpha-beta T cell activation GO:0042110 T cell activation GO:0042742 defense response to bacterium GO:0043374 CD8-positive, alpha-beta T cell differentiation GO:0046631 alpha-beta T cell activation GO:0046632 alpha-beta T cell differentiation GO:0050830 defense response to Gram-positive bacterium GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0071593 lymphocyte aggregation GO:0098542 defense response to other organism |
Molecular Function |
GO:0005125 cytokine activity GO:0005126 cytokine receptor binding GO:0005164 tumor necrosis factor receptor binding GO:0032813 tumor necrosis factor receptor superfamily binding |
Cellular Component | - |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-5668541: TNFR2 non-canonical NF-kB pathway R-HSA-5669034: TNFs bind their physiological receptors |
Summary | |
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Symbol | TNFSF8 |
Name | tumor necrosis factor (ligand) superfamily, member 8 |
Aliases | CD153; CD30LG; CD30L; CD153 antigen; CD30 antigen ligand; CD30 ligand; CD30-L; CD antigen CD153; Tumor necro ...... |
Chromosomal Location | 9q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TNFSF8 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TNFSF8 |
Name | tumor necrosis factor (ligand) superfamily, member 8 |
Aliases | CD153; CD30LG; CD30L; CD153 antigen; CD30 antigen ligand; CD30 ligand; CD30-L; CD antigen CD153; Tumor necro ...... |
Chromosomal Location | 9q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TNFSF8 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TNFSF8 |
Name | tumor necrosis factor (ligand) superfamily, member 8 |
Aliases | CD153; CD30LG; CD30L; CD153 antigen; CD30 antigen ligand; CD30 ligand; CD30-L; CD antigen CD153; Tumor necro ...... |
Chromosomal Location | 9q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TNFSF8 in various data sets.
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Points in the above scatter plot represent the mutation difference of TNFSF8 in various data sets.
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Summary | |
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Symbol | TNFSF8 |
Name | tumor necrosis factor (ligand) superfamily, member 8 |
Aliases | CD153; CD30LG; CD30L; CD153 antigen; CD30 antigen ligand; CD30 ligand; CD30-L; CD antigen CD153; Tumor necro ...... |
Chromosomal Location | 9q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TNFSF8. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | TNFSF8 |
Name | tumor necrosis factor (ligand) superfamily, member 8 |
Aliases | CD153; CD30LG; CD30L; CD153 antigen; CD30 antigen ligand; CD30 ligand; CD30-L; CD antigen CD153; Tumor necro ...... |
Chromosomal Location | 9q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TNFSF8. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TNFSF8. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TNFSF8 |
Name | tumor necrosis factor (ligand) superfamily, member 8 |
Aliases | CD153; CD30LG; CD30L; CD153 antigen; CD30 antigen ligand; CD30 ligand; CD30-L; CD antigen CD153; Tumor necro ...... |
Chromosomal Location | 9q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TNFSF8. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | TNFSF8 |
Name | tumor necrosis factor (ligand) superfamily, member 8 |
Aliases | CD153; CD30LG; CD30L; CD153 antigen; CD30 antigen ligand; CD30 ligand; CD30-L; CD antigen CD153; Tumor necro ...... |
Chromosomal Location | 9q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TNFSF8 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | TNFSF8 |
Name | tumor necrosis factor (ligand) superfamily, member 8 |
Aliases | CD153; CD30LG; CD30L; CD153 antigen; CD30 antigen ligand; CD30 ligand; CD30-L; CD antigen CD153; Tumor necro ...... |
Chromosomal Location | 9q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TNFSF8 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | TNFSF8 |
Name | tumor necrosis factor (ligand) superfamily, member 8 |
Aliases | CD153; CD30LG; CD30L; CD153 antigen; CD30 antigen ligand; CD30 ligand; CD30-L; CD antigen CD153; Tumor necro ...... |
Chromosomal Location | 9q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TNFSF8 collected from DrugBank database. |
There is no record. |