Browse TNNC1

Summary
SymbolTNNC1
Nametroponin C type 1 (slow)
Aliases TNNC; troponin C, slow; CMD1Z; CMH13; cardiac troponin C; slow twitch skeletal/cardiac muscle troponin C; tr ......
Chromosomal Location3p21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location -
Domain PF13499 EF-hand domain pair
PF13833 EF-hand domain pair
Function

Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

> Gene Ontology
 
Biological Process GO:0002086 diaphragm contraction
GO:0003007 heart morphogenesis
GO:0003009 skeletal muscle contraction
GO:0003011 involuntary skeletal muscle contraction
GO:0003012 muscle system process
GO:0003013 circulatory system process
GO:0003015 heart process
GO:0003016 respiratory system process
GO:0003205 cardiac chamber development
GO:0003206 cardiac chamber morphogenesis
GO:0003208 cardiac ventricle morphogenesis
GO:0003229 ventricular cardiac muscle tissue development
GO:0003231 cardiac ventricle development
GO:0006936 muscle contraction
GO:0006937 regulation of muscle contraction
GO:0006941 striated muscle contraction
GO:0007507 heart development
GO:0007517 muscle organ development
GO:0007585 respiratory gaseous exchange
GO:0008015 blood circulation
GO:0010035 response to inorganic substance
GO:0010038 response to metal ion
GO:0014706 striated muscle tissue development
GO:0014733 regulation of skeletal muscle adaptation
GO:0014883 transition between fast and slow fiber
GO:0014888 striated muscle adaptation
GO:0030048 actin filament-based movement
GO:0030049 muscle filament sliding
GO:0032386 regulation of intracellular transport
GO:0032970 regulation of actin filament-based process
GO:0032971 regulation of muscle filament sliding
GO:0032972 regulation of muscle filament sliding speed
GO:0033275 actin-myosin filament sliding
GO:0043462 regulation of ATPase activity
GO:0043500 muscle adaptation
GO:0043501 skeletal muscle adaptation
GO:0043502 regulation of muscle adaptation
GO:0044057 regulation of system process
GO:0048644 muscle organ morphogenesis
GO:0048738 cardiac muscle tissue development
GO:0050879 multicellular organismal movement
GO:0050881 musculoskeletal movement
GO:0055008 cardiac muscle tissue morphogenesis
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060047 heart contraction
GO:0060048 cardiac muscle contraction
GO:0060415 muscle tissue morphogenesis
GO:0060537 muscle tissue development
GO:0070252 actin-mediated cell contraction
GO:0090257 regulation of muscle system process
GO:1903115 regulation of actin filament-based movement
Molecular Function GO:0003779 actin binding
GO:0031013 troponin I binding
GO:0031014 troponin T binding
GO:0048306 calcium-dependent protein binding
GO:0051015 actin filament binding
Cellular Component GO:0005861 troponin complex
GO:0005865 striated muscle thin filament
GO:0015629 actin cytoskeleton
GO:0030016 myofibril
GO:0030017 sarcomere
GO:0036379 myofilament
GO:0043292 contractile fiber
GO:0044449 contractile fiber part
> KEGG and Reactome Pathway
 
KEGG hsa04020 Calcium signaling pathway
hsa04260 Cardiac muscle contraction
hsa04261 Adrenergic signaling in cardiomyocytes
Reactome R-HSA-397014: Muscle contraction
R-HSA-390522: Striated Muscle Contraction
Summary
SymbolTNNC1
Nametroponin C type 1 (slow)
Aliases TNNC; troponin C, slow; CMD1Z; CMH13; cardiac troponin C; slow twitch skeletal/cardiac muscle troponin C; tr ......
Chromosomal Location3p21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between TNNC1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolTNNC1
Nametroponin C type 1 (slow)
Aliases TNNC; troponin C, slow; CMD1Z; CMH13; cardiac troponin C; slow twitch skeletal/cardiac muscle troponin C; tr ......
Chromosomal Location3p21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of TNNC1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolTNNC1
Nametroponin C type 1 (slow)
Aliases TNNC; troponin C, slow; CMD1Z; CMH13; cardiac troponin C; slow twitch skeletal/cardiac muscle troponin C; tr ......
Chromosomal Location3p21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of TNNC1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.4380.419
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.2910.741
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.9630.193
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.5970.436
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.550.649
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.6510.627
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-1.6340.0196
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0230.984
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-3.3480.00958
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.0040.998
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.010.995
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.3920.198
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of TNNC1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolTNNC1
Nametroponin C type 1 (slow)
Aliases TNNC; troponin C, slow; CMD1Z; CMH13; cardiac troponin C; slow twitch skeletal/cardiac muscle troponin C; tr ......
Chromosomal Location3p21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TNNC1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolTNNC1
Nametroponin C type 1 (slow)
Aliases TNNC; troponin C, slow; CMD1Z; CMH13; cardiac troponin C; slow twitch skeletal/cardiac muscle troponin C; tr ......
Chromosomal Location3p21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TNNC1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TNNC1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolTNNC1
Nametroponin C type 1 (slow)
Aliases TNNC; troponin C, slow; CMD1Z; CMH13; cardiac troponin C; slow twitch skeletal/cardiac muscle troponin C; tr ......
Chromosomal Location3p21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TNNC1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolTNNC1
Nametroponin C type 1 (slow)
Aliases TNNC; troponin C, slow; CMD1Z; CMH13; cardiac troponin C; slow twitch skeletal/cardiac muscle troponin C; tr ......
Chromosomal Location3p21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of TNNC1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolTNNC1
Nametroponin C type 1 (slow)
Aliases TNNC; troponin C, slow; CMD1Z; CMH13; cardiac troponin C; slow twitch skeletal/cardiac muscle troponin C; tr ......
Chromosomal Location3p21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between TNNC1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolTNNC1
Nametroponin C type 1 (slow)
Aliases TNNC; troponin C, slow; CMD1Z; CMH13; cardiac troponin C; slow twitch skeletal/cardiac muscle troponin C; tr ......
Chromosomal Location3p21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting TNNC1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting TNNC1.
ID Name Drug Type Targets #Targets
DB00831TrifluoperazineSmall MoleculeADRA1A, CALY, DRD2, S100A4, TNNC15
DB00922LevosimendanSmall MoleculeKCNJ11, KCNJ8, PDE3A, TNNC14
DB01023FelodipineSmall MoleculeCACNA1C, CACNA1D, CACNA1H, CACNA1S, CACNA2D1, CACNA2D2, CACNB2, NR ......12
DB01244BepridilSmall MoleculeATP1A1, CACNA1A, CACNA1H, CACNA2D2, KCNH2, KCNQ1, PDE1A, PDE1B, TN ......9
DB01373CalciumSmall MoleculeALPP, AOC1, ATP2C1, BMP4, CACNA1C, CAST, COMP, CP, MGP, PCDH19, PD ......19
DB01375Aluminium monostearateSmall MoleculeTNNC1, VDAC1, VDAC2, VDAC34
DB039445-[1-(3,4-Dimethoxy-Benzoyl)-1,2,3,4-Tetrahydro-Quinolin-6-Yl]-6-Methyl-3,6-Dihydro-[1,3,4]Thiadiazin-2-OneSmall MoleculeTNNC11
DB04513N-(6-Aminohexyl)-5-Chloro-1-NaphthalenesulfonamideSmall MoleculeTNNC1, TNNI32