Summary | |
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Symbol | TOMM40L |
Name | translocase of outer mitochondrial membrane 40 homolog (yeast)-like |
Aliases | FLJ12770; TOMM40B; translocase of outer mitochondrial membrane 40 homolog-like (yeast); protein TOMM40-like; ...... |
Chromosomal Location | 1q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Mitochondrion outer membrane Multi-pass membrane protein |
Domain |
PF01459 Eukaryotic porin |
Function |
Potential channel-forming protein implicated in import of protein precursors into mitochondria. |
Biological Process |
GO:0006626 protein targeting to mitochondrion GO:0006839 mitochondrial transport GO:0017038 protein import GO:0030150 protein import into mitochondrial matrix GO:0044743 intracellular protein transmembrane import GO:0065002 intracellular protein transmembrane transport GO:0070585 protein localization to mitochondrion GO:0071806 protein transmembrane transport GO:0072655 establishment of protein localization to mitochondrion GO:1990542 mitochondrial transmembrane transport |
Molecular Function |
GO:0008320 protein transmembrane transporter activity GO:0008565 protein transporter activity GO:0015266 protein channel activity GO:0015267 channel activity GO:0015288 porin activity GO:0022803 passive transmembrane transporter activity GO:0022829 wide pore channel activity GO:0022884 macromolecule transmembrane transporter activity |
Cellular Component |
GO:0005741 mitochondrial outer membrane GO:0005742 mitochondrial outer membrane translocase complex GO:0019867 outer membrane GO:0031968 organelle outer membrane GO:0044455 mitochondrial membrane part GO:0046930 pore complex GO:0098798 mitochondrial protein complex GO:0098799 outer mitochondrial membrane protein complex |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | TOMM40L |
Name | translocase of outer mitochondrial membrane 40 homolog (yeast)-like |
Aliases | FLJ12770; TOMM40B; translocase of outer mitochondrial membrane 40 homolog-like (yeast); protein TOMM40-like; ...... |
Chromosomal Location | 1q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TOMM40L and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TOMM40L |
Name | translocase of outer mitochondrial membrane 40 homolog (yeast)-like |
Aliases | FLJ12770; TOMM40B; translocase of outer mitochondrial membrane 40 homolog-like (yeast); protein TOMM40-like; ...... |
Chromosomal Location | 1q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TOMM40L in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TOMM40L |
Name | translocase of outer mitochondrial membrane 40 homolog (yeast)-like |
Aliases | FLJ12770; TOMM40B; translocase of outer mitochondrial membrane 40 homolog-like (yeast); protein TOMM40-like; ...... |
Chromosomal Location | 1q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TOMM40L in various data sets.
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Points in the above scatter plot represent the mutation difference of TOMM40L in various data sets.
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Summary | |
---|---|
Symbol | TOMM40L |
Name | translocase of outer mitochondrial membrane 40 homolog (yeast)-like |
Aliases | FLJ12770; TOMM40B; translocase of outer mitochondrial membrane 40 homolog-like (yeast); protein TOMM40-like; ...... |
Chromosomal Location | 1q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TOMM40L. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TOMM40L |
Name | translocase of outer mitochondrial membrane 40 homolog (yeast)-like |
Aliases | FLJ12770; TOMM40B; translocase of outer mitochondrial membrane 40 homolog-like (yeast); protein TOMM40-like; ...... |
Chromosomal Location | 1q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TOMM40L. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TOMM40L. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TOMM40L |
Name | translocase of outer mitochondrial membrane 40 homolog (yeast)-like |
Aliases | FLJ12770; TOMM40B; translocase of outer mitochondrial membrane 40 homolog-like (yeast); protein TOMM40-like; ...... |
Chromosomal Location | 1q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TOMM40L. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | TOMM40L |
Name | translocase of outer mitochondrial membrane 40 homolog (yeast)-like |
Aliases | FLJ12770; TOMM40B; translocase of outer mitochondrial membrane 40 homolog-like (yeast); protein TOMM40-like; ...... |
Chromosomal Location | 1q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TOMM40L expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TOMM40L |
Name | translocase of outer mitochondrial membrane 40 homolog (yeast)-like |
Aliases | FLJ12770; TOMM40B; translocase of outer mitochondrial membrane 40 homolog-like (yeast); protein TOMM40-like; ...... |
Chromosomal Location | 1q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TOMM40L and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TOMM40L |
Name | translocase of outer mitochondrial membrane 40 homolog (yeast)-like |
Aliases | FLJ12770; TOMM40B; translocase of outer mitochondrial membrane 40 homolog-like (yeast); protein TOMM40-like; ...... |
Chromosomal Location | 1q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TOMM40L collected from DrugBank database. |
There is no record. |