Summary | |
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Symbol | TOMM7 |
Name | translocase of outer mitochondrial membrane 7 homolog (yeast) |
Aliases | TOM7; 6.2 kd protein; translocase of outer membrane 7 kDa subunit homolog; Mitochondrial import receptor sub ...... |
Chromosomal Location | 7p15.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Mitochondrion outer membrane Single-pass membrane protein |
Domain |
PF08038 TOM7 family |
Function |
Required for assembly and stability of the TOM complex. Positive regulator of PRKN translocation to damaged mitochondria. Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria. |
Biological Process |
GO:0000422 mitophagy GO:0000423 macromitophagy GO:0006626 protein targeting to mitochondrion GO:0006839 mitochondrial transport GO:0006914 autophagy GO:0007006 mitochondrial membrane organization GO:0007008 outer mitochondrial membrane organization GO:0010821 regulation of mitochondrion organization GO:0010822 positive regulation of mitochondrion organization GO:0016236 macroautophagy GO:0017038 protein import GO:0030150 protein import into mitochondrial matrix GO:0031647 regulation of protein stability GO:0032386 regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0033157 regulation of intracellular protein transport GO:0044743 intracellular protein transmembrane import GO:0045040 protein import into mitochondrial outer membrane GO:0051222 positive regulation of protein transport GO:0061726 mitochondrion disassembly GO:0065002 intracellular protein transmembrane transport GO:0070585 protein localization to mitochondrion GO:0071806 protein transmembrane transport GO:0072655 establishment of protein localization to mitochondrion GO:0072657 protein localization to membrane GO:0090150 establishment of protein localization to membrane GO:0090151 establishment of protein localization to mitochondrial membrane GO:0090316 positive regulation of intracellular protein transport GO:0098779 mitophagy in response to mitochondrial depolarization GO:0098780 response to mitochondrial depolarisation GO:1903008 organelle disassembly GO:1903214 regulation of protein targeting to mitochondrion GO:1903533 regulation of protein targeting GO:1903747 regulation of establishment of protein localization to mitochondrion GO:1903749 positive regulation of establishment of protein localization to mitochondrion GO:1903829 positive regulation of cellular protein localization GO:1903955 positive regulation of protein targeting to mitochondrion GO:1904951 positive regulation of establishment of protein localization GO:1990542 mitochondrial transmembrane transport |
Molecular Function |
GO:0008320 protein transmembrane transporter activity GO:0008565 protein transporter activity GO:0015266 protein channel activity GO:0015267 channel activity GO:0022803 passive transmembrane transporter activity GO:0022884 macromolecule transmembrane transporter activity |
Cellular Component |
GO:0005741 mitochondrial outer membrane GO:0005742 mitochondrial outer membrane translocase complex GO:0019867 outer membrane GO:0031300 intrinsic component of organelle membrane GO:0031301 integral component of organelle membrane GO:0031306 intrinsic component of mitochondrial outer membrane GO:0031307 integral component of mitochondrial outer membrane GO:0031968 organelle outer membrane GO:0032592 integral component of mitochondrial membrane GO:0044455 mitochondrial membrane part GO:0098573 intrinsic component of mitochondrial membrane GO:0098798 mitochondrial protein complex GO:0098799 outer mitochondrial membrane protein complex |
KEGG | - |
Reactome |
R-HSA-392499: Metabolism of proteins R-HSA-1268020: Mitochondrial protein import R-HSA-5205647: Mitophagy R-HSA-5205685: Pink/Parkin Mediated Mitophagy |
Summary | |
---|---|
Symbol | TOMM7 |
Name | translocase of outer mitochondrial membrane 7 homolog (yeast) |
Aliases | TOM7; 6.2 kd protein; translocase of outer membrane 7 kDa subunit homolog; Mitochondrial import receptor sub ...... |
Chromosomal Location | 7p15.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TOMM7 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TOMM7 |
Name | translocase of outer mitochondrial membrane 7 homolog (yeast) |
Aliases | TOM7; 6.2 kd protein; translocase of outer membrane 7 kDa subunit homolog; Mitochondrial import receptor sub ...... |
Chromosomal Location | 7p15.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TOMM7 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | TOMM7 |
Name | translocase of outer mitochondrial membrane 7 homolog (yeast) |
Aliases | TOM7; 6.2 kd protein; translocase of outer membrane 7 kDa subunit homolog; Mitochondrial import receptor sub ...... |
Chromosomal Location | 7p15.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TOMM7 in various data sets.
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There is no record. |
Summary | |
---|---|
Symbol | TOMM7 |
Name | translocase of outer mitochondrial membrane 7 homolog (yeast) |
Aliases | TOM7; 6.2 kd protein; translocase of outer membrane 7 kDa subunit homolog; Mitochondrial import receptor sub ...... |
Chromosomal Location | 7p15.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TOMM7. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TOMM7 |
Name | translocase of outer mitochondrial membrane 7 homolog (yeast) |
Aliases | TOM7; 6.2 kd protein; translocase of outer membrane 7 kDa subunit homolog; Mitochondrial import receptor sub ...... |
Chromosomal Location | 7p15.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TOMM7. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TOMM7. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | TOMM7 |
Name | translocase of outer mitochondrial membrane 7 homolog (yeast) |
Aliases | TOM7; 6.2 kd protein; translocase of outer membrane 7 kDa subunit homolog; Mitochondrial import receptor sub ...... |
Chromosomal Location | 7p15.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TOMM7. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TOMM7 |
Name | translocase of outer mitochondrial membrane 7 homolog (yeast) |
Aliases | TOM7; 6.2 kd protein; translocase of outer membrane 7 kDa subunit homolog; Mitochondrial import receptor sub ...... |
Chromosomal Location | 7p15.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TOMM7 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TOMM7 |
Name | translocase of outer mitochondrial membrane 7 homolog (yeast) |
Aliases | TOM7; 6.2 kd protein; translocase of outer membrane 7 kDa subunit homolog; Mitochondrial import receptor sub ...... |
Chromosomal Location | 7p15.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TOMM7 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TOMM7 |
Name | translocase of outer mitochondrial membrane 7 homolog (yeast) |
Aliases | TOM7; 6.2 kd protein; translocase of outer membrane 7 kDa subunit homolog; Mitochondrial import receptor sub ...... |
Chromosomal Location | 7p15.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TOMM7 collected from DrugBank database. |
There is no record. |