Summary | |
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Symbol | TOP1MT |
Name | topoisomerase (DNA) I, mitochondrial |
Aliases | mitochondrial topoisomerase IB; DNA topoisomerase I, mitochondrial |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Mitochondrion |
Domain |
PF14370 C-terminal topoisomerase domain PF01028 Eukaryotic DNA topoisomerase I PF02919 Eukaryotic DNA topoisomerase I |
Function |
Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). |
Biological Process |
GO:0006260 DNA replication GO:0006265 DNA topological change GO:0071103 DNA conformation change |
Molecular Function |
GO:0003916 DNA topoisomerase activity GO:0003917 DNA topoisomerase type I activity GO:0016853 isomerase activity |
Cellular Component |
GO:0005759 mitochondrial matrix GO:0009295 nucleoid GO:0042645 mitochondrial nucleoid |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | TOP1MT |
Name | topoisomerase (DNA) I, mitochondrial |
Aliases | mitochondrial topoisomerase IB; DNA topoisomerase I, mitochondrial |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TOP1MT and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TOP1MT |
Name | topoisomerase (DNA) I, mitochondrial |
Aliases | mitochondrial topoisomerase IB; DNA topoisomerase I, mitochondrial |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TOP1MT in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | TOP1MT |
Name | topoisomerase (DNA) I, mitochondrial |
Aliases | mitochondrial topoisomerase IB; DNA topoisomerase I, mitochondrial |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TOP1MT in various data sets.
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Points in the above scatter plot represent the mutation difference of TOP1MT in various data sets.
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Summary | |
---|---|
Symbol | TOP1MT |
Name | topoisomerase (DNA) I, mitochondrial |
Aliases | mitochondrial topoisomerase IB; DNA topoisomerase I, mitochondrial |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TOP1MT. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TOP1MT |
Name | topoisomerase (DNA) I, mitochondrial |
Aliases | mitochondrial topoisomerase IB; DNA topoisomerase I, mitochondrial |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TOP1MT. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TOP1MT. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TOP1MT |
Name | topoisomerase (DNA) I, mitochondrial |
Aliases | mitochondrial topoisomerase IB; DNA topoisomerase I, mitochondrial |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TOP1MT. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TOP1MT |
Name | topoisomerase (DNA) I, mitochondrial |
Aliases | mitochondrial topoisomerase IB; DNA topoisomerase I, mitochondrial |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TOP1MT expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TOP1MT |
Name | topoisomerase (DNA) I, mitochondrial |
Aliases | mitochondrial topoisomerase IB; DNA topoisomerase I, mitochondrial |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TOP1MT and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TOP1MT |
Name | topoisomerase (DNA) I, mitochondrial |
Aliases | mitochondrial topoisomerase IB; DNA topoisomerase I, mitochondrial |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TOP1MT collected from DrugBank database. |
Details on drugs targeting TOP1MT.
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