Browse TOP1MT

Summary
SymbolTOP1MT
Nametopoisomerase (DNA) I, mitochondrial
Aliases mitochondrial topoisomerase IB; DNA topoisomerase I, mitochondrial
Chromosomal Location8q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Mitochondrion
Domain PF14370 C-terminal topoisomerase domain
PF01028 Eukaryotic DNA topoisomerase I
PF02919 Eukaryotic DNA topoisomerase I
Function

Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity).

> Gene Ontology
 
Biological Process GO:0006260 DNA replication
GO:0006265 DNA topological change
GO:0071103 DNA conformation change
Molecular Function GO:0003916 DNA topoisomerase activity
GO:0003917 DNA topoisomerase type I activity
GO:0016853 isomerase activity
Cellular Component GO:0005759 mitochondrial matrix
GO:0009295 nucleoid
GO:0042645 mitochondrial nucleoid
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolTOP1MT
Nametopoisomerase (DNA) I, mitochondrial
Aliases mitochondrial topoisomerase IB; DNA topoisomerase I, mitochondrial
Chromosomal Location8q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between TOP1MT and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolTOP1MT
Nametopoisomerase (DNA) I, mitochondrial
Aliases mitochondrial topoisomerase IB; DNA topoisomerase I, mitochondrial
Chromosomal Location8q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of TOP1MT in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolTOP1MT
Nametopoisomerase (DNA) I, mitochondrial
Aliases mitochondrial topoisomerase IB; DNA topoisomerase I, mitochondrial
Chromosomal Location8q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of TOP1MT in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.3740.261
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.0410.613
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.1060.948
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.040.893
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.0970.958
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.2110.929
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0090.984
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.4930.743
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.5810.724
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.0620.964
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.5320.781
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.2440.0201
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of TOP1MT in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.1011.10.0181
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.1011.10.0286
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211705.9-5.90.447
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131109.1-9.10.458
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91633.3258.30.673
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 594011.128.90.505
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 472542.9-17.91
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolTOP1MT
Nametopoisomerase (DNA) I, mitochondrial
Aliases mitochondrial topoisomerase IB; DNA topoisomerase I, mitochondrial
Chromosomal Location8q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TOP1MT. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolTOP1MT
Nametopoisomerase (DNA) I, mitochondrial
Aliases mitochondrial topoisomerase IB; DNA topoisomerase I, mitochondrial
Chromosomal Location8q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TOP1MT. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TOP1MT.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolTOP1MT
Nametopoisomerase (DNA) I, mitochondrial
Aliases mitochondrial topoisomerase IB; DNA topoisomerase I, mitochondrial
Chromosomal Location8q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TOP1MT. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolTOP1MT
Nametopoisomerase (DNA) I, mitochondrial
Aliases mitochondrial topoisomerase IB; DNA topoisomerase I, mitochondrial
Chromosomal Location8q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of TOP1MT expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolTOP1MT
Nametopoisomerase (DNA) I, mitochondrial
Aliases mitochondrial topoisomerase IB; DNA topoisomerase I, mitochondrial
Chromosomal Location8q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between TOP1MT and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolTOP1MT
Nametopoisomerase (DNA) I, mitochondrial
Aliases mitochondrial topoisomerase IB; DNA topoisomerase I, mitochondrial
Chromosomal Location8q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting TOP1MT collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting TOP1MT.
ID Name Drug Type Targets #Targets
DB00762IrinotecanSmall MoleculeTOP1, TOP1MT2
DB01030TopotecanSmall MoleculeTOP1, TOP1MT2