Summary | |
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Symbol | TOP2A |
Name | topoisomerase (DNA) II alpha |
Aliases | TOP2; topoisomerase (DNA) II alpha 170kDa; TP2A; DNA gyrase; DNA topoisomerase (ATP-hydrolyzing); DNA topois ...... |
Chromosomal Location | 17q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Nucleus, nucleoplasm Note=Generally located in the nucleoplasm. |
Domain |
PF00204 DNA gyrase B PF00521 DNA gyrase/topoisomerase IV PF08070 DTHCT (NUC029) region PF02518 Histidine kinase- PF01751 Toprim domain PF16898 C-terminal associated domain of TOPRIM |
Function |
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (By similarity). |
Biological Process |
GO:0000075 cell cycle checkpoint GO:0000712 resolution of meiotic recombination intermediates GO:0000819 sister chromatid segregation GO:0002244 hematopoietic progenitor cell differentiation GO:0006260 DNA replication GO:0006261 DNA-dependent DNA replication GO:0006265 DNA topological change GO:0006266 DNA ligation GO:0006268 DNA unwinding involved in DNA replication GO:0006310 DNA recombination GO:0006312 mitotic recombination GO:0006323 DNA packaging GO:0006921 cellular component disassembly involved in execution phase of apoptosis GO:0007059 chromosome segregation GO:0007093 mitotic cell cycle checkpoint GO:0007126 meiotic nuclear division GO:0007127 meiosis I GO:0007131 reciprocal meiotic recombination GO:0007346 regulation of mitotic cell cycle GO:0007623 circadian rhythm GO:0016925 protein sumoylation GO:0018205 peptidyl-lysine modification GO:0019058 viral life cycle GO:0019079 viral genome replication GO:0030261 chromosome condensation GO:0030262 apoptotic nuclear changes GO:0030263 apoptotic chromosome condensation GO:0031570 DNA integrity checkpoint GO:0032392 DNA geometric change GO:0032508 DNA duplex unwinding GO:0035825 reciprocal DNA recombination GO:0039692 single stranded viral RNA replication via double stranded DNA intermediate GO:0039694 viral RNA genome replication GO:0039703 RNA replication GO:0040016 embryonic cleavage GO:0042752 regulation of circadian rhythm GO:0043900 regulation of multi-organism process GO:0043902 positive regulation of multi-organism process GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism GO:0044033 multi-organism metabolic process GO:0044774 mitotic DNA integrity checkpoint GO:0045069 regulation of viral genome replication GO:0045070 positive regulation of viral genome replication GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate GO:0045132 meiotic chromosome segregation GO:0045786 negative regulation of cell cycle GO:0045870 positive regulation of single stranded viral RNA replication via double stranded DNA intermediate GO:0045930 negative regulation of mitotic cell cycle GO:0048511 rhythmic process GO:0048524 positive regulation of viral process GO:0050792 regulation of viral process GO:0051052 regulation of DNA metabolic process GO:0051054 positive regulation of DNA metabolic process GO:0051304 chromosome separation GO:0051307 meiotic chromosome separation GO:0051321 meiotic cell cycle GO:0071103 DNA conformation change GO:0097194 execution phase of apoptosis GO:0098813 nuclear chromosome segregation GO:1903046 meiotic cell cycle process GO:1903900 regulation of viral life cycle GO:1903902 positive regulation of viral life cycle |
Molecular Function |
GO:0000287 magnesium ion binding GO:0003682 chromatin binding GO:0003916 DNA topoisomerase activity GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity GO:0005080 protein kinase C binding GO:0008022 protein C-terminus binding GO:0008094 DNA-dependent ATPase activity GO:0008144 drug binding GO:0008301 DNA binding, bending GO:0016853 isomerase activity GO:0016887 ATPase activity GO:0032182 ubiquitin-like protein binding GO:0042623 ATPase activity, coupled GO:0042826 histone deacetylase binding GO:0043130 ubiquitin binding GO:0046982 protein heterodimerization activity GO:0061505 DNA topoisomerase II activity |
Cellular Component |
GO:0000793 condensed chromosome GO:0005813 centrosome GO:0005814 centriole GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing) GO:0019035 viral integration complex GO:0044450 microtubule organizing center part |
KEGG | - |
Reactome |
R-HSA-1640170: Cell Cycle R-HSA-69278: Cell Cycle, Mitotic R-HSA-1538133: G0 and Early G1 R-HSA-392499: Metabolism of proteins R-HSA-453279: Mitotic G1-G1/S phases R-HSA-597592: Post-translational protein modification R-HSA-3108232: SUMO E3 ligases SUMOylate target proteins R-HSA-2990846: SUMOylation R-HSA-4615885: SUMOylation of DNA replication proteins |
Summary | |
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Symbol | TOP2A |
Name | topoisomerase (DNA) II alpha |
Aliases | TOP2; topoisomerase (DNA) II alpha 170kDa; TP2A; DNA gyrase; DNA topoisomerase (ATP-hydrolyzing); DNA topois ...... |
Chromosomal Location | 17q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TOP2A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | TOP2A |
Name | topoisomerase (DNA) II alpha |
Aliases | TOP2; topoisomerase (DNA) II alpha 170kDa; TP2A; DNA gyrase; DNA topoisomerase (ATP-hydrolyzing); DNA topois ...... |
Chromosomal Location | 17q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TOP2A in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TOP2A |
Name | topoisomerase (DNA) II alpha |
Aliases | TOP2; topoisomerase (DNA) II alpha 170kDa; TP2A; DNA gyrase; DNA topoisomerase (ATP-hydrolyzing); DNA topois ...... |
Chromosomal Location | 17q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TOP2A in various data sets.
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Points in the above scatter plot represent the mutation difference of TOP2A in various data sets.
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Summary | |
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Symbol | TOP2A |
Name | topoisomerase (DNA) II alpha |
Aliases | TOP2; topoisomerase (DNA) II alpha 170kDa; TP2A; DNA gyrase; DNA topoisomerase (ATP-hydrolyzing); DNA topois ...... |
Chromosomal Location | 17q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TOP2A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | TOP2A |
Name | topoisomerase (DNA) II alpha |
Aliases | TOP2; topoisomerase (DNA) II alpha 170kDa; TP2A; DNA gyrase; DNA topoisomerase (ATP-hydrolyzing); DNA topois ...... |
Chromosomal Location | 17q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TOP2A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TOP2A. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TOP2A |
Name | topoisomerase (DNA) II alpha |
Aliases | TOP2; topoisomerase (DNA) II alpha 170kDa; TP2A; DNA gyrase; DNA topoisomerase (ATP-hydrolyzing); DNA topois ...... |
Chromosomal Location | 17q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TOP2A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | TOP2A |
Name | topoisomerase (DNA) II alpha |
Aliases | TOP2; topoisomerase (DNA) II alpha 170kDa; TP2A; DNA gyrase; DNA topoisomerase (ATP-hydrolyzing); DNA topois ...... |
Chromosomal Location | 17q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TOP2A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | TOP2A |
Name | topoisomerase (DNA) II alpha |
Aliases | TOP2; topoisomerase (DNA) II alpha 170kDa; TP2A; DNA gyrase; DNA topoisomerase (ATP-hydrolyzing); DNA topois ...... |
Chromosomal Location | 17q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TOP2A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | TOP2A |
Name | topoisomerase (DNA) II alpha |
Aliases | TOP2; topoisomerase (DNA) II alpha 170kDa; TP2A; DNA gyrase; DNA topoisomerase (ATP-hydrolyzing); DNA topois ...... |
Chromosomal Location | 17q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TOP2A collected from DrugBank database. |
Details on drugs targeting TOP2A.
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