Summary | |
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Symbol | TP53 |
Name | tumor protein p53 |
Aliases | p53; LFS1; Li-Fraumeni syndrome; BCC7; TRP53; antigen NY-CO-13; mutant tumor protein 53; p53 tumor suppresso ...... |
Chromosomal Location | 17p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. Nucleus. Nucleus, PML body. Endoplasmic reticulum. Mitochondrion matrix. Note=Interaction with BANP promotes nuclear localization. Recruited into PML bodies together with CHEK2. Translocates to mitochondria upon oxidative stress. Translocates to mitochondria in response to mitomycin C treatment (PubMed:27323408). ; SUBCELLULAR LOCATION: Isoform 1: Nucleus. Cytoplasm. Note=Predominantly nuclear but localizes to the cytoplasm when expressed with isoform 4.; SUBCELLULAR LOCATION: Isoform 2: Nucleus. Cytoplasm. Note=Localized mainly in the nucleus with minor staining in the cytoplasm.; SUBCELLULAR LOCATION: Isoform 3: Nucleus. Cytoplasm. Note=Localized in the nucleus in most cells but found in the cytoplasm in some cells.; SUBCELLULAR LOCATION: Isoform 4: Nucleus. Cytoplasm. Note=Predominantly nuclear but translocates to the cytoplasm following cell stress.; SUBCELLULAR LOCATION: Isoform 7: Nucleus. Cytoplasm. Note=Localized mainly in the nucleus with minor staining in the cytoplasm.; SUBCELLULAR LOCATION: Isoform 8: Nucleus. Cytoplasm. Note=Localized in both nucleus and cytoplasm in most cells. In some cells, forms foci in the nucleus that are different from nucleoli.; SUBCELLULAR LOCATION: Isoform 9: Cytoplasm. |
Domain |
PF00870 P53 DNA-binding domain PF08563 P53 transactivation motif PF07710 P53 tetramerisation motif |
Function |
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492). |
Biological Process |
GO:0000075 cell cycle checkpoint GO:0000077 DNA damage checkpoint GO:0000082 G1/S transition of mitotic cell cycle GO:0000733 DNA strand renaturation GO:0001558 regulation of cell growth GO:0001666 response to hypoxia GO:0001836 release of cytochrome c from mitochondria GO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:0006284 base-excision repair GO:0006289 nucleotide-excision repair GO:0006323 DNA packaging GO:0006333 chromatin assembly or disassembly GO:0006476 protein deacetylation GO:0006611 protein export from nucleus GO:0006839 mitochondrial transport GO:0006913 nucleocytoplasmic transport GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006979 response to oxidative stress GO:0006983 ER overload response GO:0006984 ER-nucleus signaling pathway GO:0007006 mitochondrial membrane organization GO:0007050 cell cycle arrest GO:0007093 mitotic cell cycle checkpoint GO:0007265 Ras protein signal transduction GO:0007346 regulation of mitotic cell cycle GO:0007568 aging GO:0007569 cell aging GO:0007622 rhythmic behavior GO:0007623 circadian rhythm GO:0008340 determination of adult lifespan GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008637 apoptotic mitochondrial changes GO:0009267 cellular response to starvation GO:0009314 response to radiation GO:0009411 response to UV GO:0009416 response to light stimulus GO:0009648 photoperiodism GO:0009649 entrainment of circadian clock GO:0009991 response to extracellular stimulus GO:0010165 response to X-ray GO:0010212 response to ionizing radiation GO:0010259 multicellular organism aging GO:0010332 response to gamma radiation GO:0010498 proteasomal protein catabolic process GO:0010821 regulation of mitochondrion organization GO:0010822 positive regulation of mitochondrion organization GO:0010948 negative regulation of cell cycle process GO:0016049 cell growth GO:0016570 histone modification GO:0016575 histone deacetylation GO:0016925 protein sumoylation GO:0018108 peptidyl-tyrosine phosphorylation GO:0018205 peptidyl-lysine modification GO:0018212 peptidyl-tyrosine modification GO:0030308 negative regulation of cell growth GO:0030330 DNA damage response, signal transduction by p53 class mediator GO:0031056 regulation of histone modification GO:0031058 positive regulation of histone modification GO:0031063 regulation of histone deacetylation GO:0031065 positive regulation of histone deacetylation GO:0031334 positive regulation of protein complex assembly GO:0031497 chromatin assembly GO:0031570 DNA integrity checkpoint GO:0031571 mitotic G1 DNA damage checkpoint GO:0031667 response to nutrient levels GO:0031668 cellular response to extracellular stimulus GO:0031669 cellular response to nutrient levels GO:0032386 regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0032459 regulation of protein oligomerization GO:0032461 positive regulation of protein oligomerization GO:0033157 regulation of intracellular protein transport GO:0034349 glial cell apoptotic process GO:0034599 cellular response to oxidative stress GO:0034644 cellular response to UV GO:0034976 response to endoplasmic reticulum stress GO:0035601 protein deacylation GO:0035690 cellular response to drug GO:0035794 positive regulation of mitochondrial membrane permeability GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0036293 response to decreased oxygen levels GO:0036294 cellular response to decreased oxygen levels GO:0042149 cellular response to glucose starvation GO:0042493 response to drug GO:0042594 response to starvation GO:0042752 regulation of circadian rhythm GO:0042770 signal transduction in response to DNA damage GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042772 DNA damage response, signal transduction resulting in transcription GO:0043153 entrainment of circadian clock by photoperiod GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043254 regulation of protein complex assembly GO:0043523 regulation of neuron apoptotic process GO:0043525 positive regulation of neuron apoptotic process GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress GO:0043620 regulation of DNA-templated transcription in response to stress GO:0044089 positive regulation of cellular component biogenesis GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044773 mitotic DNA damage checkpoint GO:0044774 mitotic DNA integrity checkpoint GO:0044783 G1 DNA damage checkpoint GO:0044819 mitotic G1/S transition checkpoint GO:0044839 cell cycle G2/M phase transition GO:0044843 cell cycle G1/S phase transition GO:0045786 negative regulation of cell cycle GO:0045787 positive regulation of cell cycle GO:0045926 negative regulation of growth GO:0045930 negative regulation of mitotic cell cycle GO:0046677 response to antibiotic GO:0046822 regulation of nucleocytoplasmic transport GO:0046824 positive regulation of nucleocytoplasmic transport GO:0046825 regulation of protein export from nucleus GO:0046827 positive regulation of protein export from nucleus GO:0046902 regulation of mitochondrial membrane permeability GO:0048144 fibroblast proliferation GO:0048145 regulation of fibroblast proliferation GO:0048147 negative regulation of fibroblast proliferation GO:0048511 rhythmic process GO:0048512 circadian behavior GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0051052 regulation of DNA metabolic process GO:0051053 negative regulation of DNA metabolic process GO:0051095 regulation of helicase activity GO:0051097 negative regulation of helicase activity GO:0051168 nuclear export GO:0051169 nuclear transport GO:0051204 protein insertion into mitochondrial membrane GO:0051205 protein insertion into membrane GO:0051222 positive regulation of protein transport GO:0051259 protein oligomerization GO:0051262 protein tetramerization GO:0051346 negative regulation of hydrolase activity GO:0051348 negative regulation of transferase activity GO:0051402 neuron apoptotic process GO:0051972 regulation of telomerase activity GO:0051974 negative regulation of telomerase activity GO:0070227 lymphocyte apoptotic process GO:0070228 regulation of lymphocyte apoptotic process GO:0070230 positive regulation of lymphocyte apoptotic process GO:0070231 T cell apoptotic process GO:0070232 regulation of T cell apoptotic process GO:0070234 positive regulation of T cell apoptotic process GO:0070242 thymocyte apoptotic process GO:0070243 regulation of thymocyte apoptotic process GO:0070245 positive regulation of thymocyte apoptotic process GO:0070482 response to oxygen levels GO:0070585 protein localization to mitochondrion GO:0070997 neuron death GO:0071103 DNA conformation change GO:0071156 regulation of cell cycle arrest GO:0071158 positive regulation of cell cycle arrest GO:0071214 cellular response to abiotic stimulus GO:0071216 cellular response to biotic stimulus GO:0071453 cellular response to oxygen levels GO:0071456 cellular response to hypoxia GO:0071478 cellular response to radiation GO:0071479 cellular response to ionizing radiation GO:0071482 cellular response to light stimulus GO:0071496 cellular response to external stimulus GO:0071887 leukocyte apoptotic process GO:0071897 DNA biosynthetic process GO:0072331 signal transduction by p53 class mediator GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator GO:0072395 signal transduction involved in cell cycle checkpoint GO:0072401 signal transduction involved in DNA integrity checkpoint GO:0072413 signal transduction involved in mitotic cell cycle checkpoint GO:0072422 signal transduction involved in DNA damage checkpoint GO:0072431 signal transduction involved in mitotic G1 DNA damage checkpoint GO:0072593 reactive oxygen species metabolic process GO:0072655 establishment of protein localization to mitochondrion GO:0072657 protein localization to membrane GO:0090068 positive regulation of cell cycle process GO:0090150 establishment of protein localization to membrane GO:0090199 regulation of release of cytochrome c from mitochondria GO:0090200 positive regulation of release of cytochrome c from mitochondria GO:0090311 regulation of protein deacetylation GO:0090312 positive regulation of protein deacetylation GO:0090316 positive regulation of intracellular protein transport GO:0090398 cellular senescence GO:0090399 replicative senescence GO:0090400 stress-induced premature senescence GO:0090403 oxidative stress-induced premature senescence GO:0090559 regulation of membrane permeability GO:0097193 intrinsic apoptotic signaling pathway GO:0097194 execution phase of apoptosis GO:0097252 oligodendrocyte apoptotic process GO:0097345 mitochondrial outer membrane permeabilization GO:0098732 macromolecule deacylation GO:1900117 regulation of execution phase of apoptosis GO:1900119 positive regulation of execution phase of apoptosis GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO:1901214 regulation of neuron death GO:1901216 positive regulation of neuron death GO:1901796 regulation of signal transduction by p53 class mediator GO:1901987 regulation of cell cycle phase transition GO:1901988 negative regulation of cell cycle phase transition GO:1901990 regulation of mitotic cell cycle phase transition GO:1901991 negative regulation of mitotic cell cycle phase transition GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902275 regulation of chromatin organization GO:1902400 intracellular signal transduction involved in G1 DNA damage checkpoint GO:1902402 signal transduction involved in mitotic DNA damage checkpoint GO:1902403 signal transduction involved in mitotic DNA integrity checkpoint GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death GO:1902749 regulation of cell cycle G2/M phase transition GO:1902806 regulation of cell cycle G1/S phase transition GO:1902807 negative regulation of cell cycle G1/S phase transition GO:1903747 regulation of establishment of protein localization to mitochondrion GO:1903749 positive regulation of establishment of protein localization to mitochondrion GO:1903829 positive regulation of cellular protein localization GO:1904951 positive regulation of establishment of protein localization GO:1905269 positive regulation of chromatin organization GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress GO:2000045 regulation of G1/S transition of mitotic cell cycle GO:2000106 regulation of leukocyte apoptotic process GO:2000108 positive regulation of leukocyte apoptotic process GO:2000134 negative regulation of G1/S transition of mitotic cell cycle GO:2000278 regulation of DNA biosynthetic process GO:2000279 negative regulation of DNA biosynthetic process GO:2000377 regulation of reactive oxygen species metabolic process GO:2000379 positive regulation of reactive oxygen species metabolic process GO:2001233 regulation of apoptotic signaling pathway GO:2001235 positive regulation of apoptotic signaling pathway GO:2001242 regulation of intrinsic apoptotic signaling pathway GO:2001244 positive regulation of intrinsic apoptotic signaling pathway |
Molecular Function |
GO:0001046 core promoter sequence-specific DNA binding GO:0001047 core promoter binding GO:0001085 RNA polymerase II transcription factor binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0002020 protease binding GO:0002039 p53 binding GO:0003682 chromatin binding GO:0003684 damaged DNA binding GO:0005507 copper ion binding GO:0008134 transcription factor binding GO:0019902 phosphatase binding GO:0019903 protein phosphatase binding GO:0030971 receptor tyrosine kinase binding GO:0031625 ubiquitin protein ligase binding GO:0035035 histone acetyltransferase binding GO:0043621 protein self-association GO:0044389 ubiquitin-like protein ligase binding GO:0046982 protein heterodimerization activity GO:0047485 protein N-terminus binding GO:0051087 chaperone binding GO:0051721 protein phosphatase 2A binding GO:1990782 protein tyrosine kinase binding |
Cellular Component |
GO:0000428 DNA-directed RNA polymerase complex GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0005657 replication fork GO:0005667 transcription factor complex GO:0005669 transcription factor TFIID complex GO:0005759 mitochondrial matrix GO:0016363 nuclear matrix GO:0016591 DNA-directed RNA polymerase II, holoenzyme GO:0016604 nuclear body GO:0016605 PML body GO:0030880 RNA polymerase complex GO:0034399 nuclear periphery GO:0044454 nuclear chromosome part GO:0044798 nuclear transcription factor complex GO:0055029 nuclear DNA-directed RNA polymerase complex GO:0061695 transferase complex, transferring phosphorus-containing groups GO:0090575 RNA polymerase II transcription factor complex |
KEGG |
hsa04010 MAPK signaling pathway hsa04071 Sphingolipid signaling pathway hsa04110 Cell cycle hsa04115 p53 signaling pathway hsa04151 PI3K-Akt signaling pathway hsa04210 Apoptosis hsa04310 Wnt signaling pathway hsa04722 Neurotrophin signaling pathway hsa04919 Thyroid hormone signaling pathway |
Reactome |
R-HSA-114452: Activation of BH3-only proteins R-HSA-111448: Activation of NOXA and translocation to mitochondria R-HSA-139915: Activation of PUMA and translocation to mitochondria R-HSA-1280218: Adaptive Immune System R-HSA-109581: Apoptosis R-HSA-390471: Association of TriC/CCT with target proteins during biosynthesis R-HSA-349425: Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-1640170: Cell Cycle R-HSA-69620: Cell Cycle Checkpoints R-HSA-69278: Cell Cycle, Mitotic R-HSA-2559583: Cellular Senescence R-HSA-2262752: Cellular responses to stress R-HSA-390466: Chaperonin-mediated protein folding R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-2172127: DAP12 interactions R-HSA-2424491: DAP12 signaling R-HSA-2559586: DNA Damage/Telomere Stress Induced Senescence R-HSA-5693606: DNA Double Strand Break Response R-HSA-5693532: DNA Double-Strand Break Repair R-HSA-73894: DNA Repair R-HSA-5688426: Deubiquitination R-HSA-186763: Downstream signal transduction R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR) R-HSA-983231: Factors involved in megakaryocyte development and platelet production R-HSA-2454202: Fc epsilon receptor (FCERI) signaling R-HSA-2559584: Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-69615: G1/S DNA Damage Checkpoints R-HSA-69481: G2/M Checkpoints R-HSA-69473: G2/M DNA damage checkpoint R-HSA-69275: G2/M Transition R-HSA-180292: GAB1 signalosome R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-109582: Hemostasis R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-6785807: Interleukin-4 and 13 signaling R-HSA-109606: Intrinsic Pathway for Apoptosis R-HSA-392499: Metabolism of proteins R-HSA-453274: Mitotic G2-G2/M phases R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-2559585: Oncogene Induced Senescence R-HSA-5689896: Ovarian tumor domain proteases R-HSA-2559580: Oxidative Stress Induced Senescence R-HSA-198203: PI3K/AKT activation R-HSA-6811555: PI5P Regulates TP53 Acetylation R-HSA-1257604: PIP3 activates AKT signaling R-HSA-597592: Post-translational protein modification R-HSA-1912422: Pre-NOTCH Expression and Processing R-HSA-1912408: Pre-NOTCH Transcription and Translation R-HSA-5357801: Programmed Cell Death R-HSA-391251: Protein folding R-HSA-5693565: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5633007: Regulation of TP53 Activity R-HSA-6804758: Regulation of TP53 Activity through Acetylation R-HSA-6804759: Regulation of TP53 Activity through Association with Co-factors R-HSA-6804760: Regulation of TP53 Activity through Methylation R-HSA-6804756: Regulation of TP53 Activity through Phosphorylation R-HSA-6804757: Regulation of TP53 Degradation R-HSA-6804754: Regulation of TP53 Expression R-HSA-6806003: Regulation of TP53 Expression and Degradation R-HSA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-3108232: SUMO E3 ligases SUMOylate target proteins R-HSA-2990846: SUMOylation R-HSA-3232118: SUMOylation of transcription factors R-HSA-162582: Signal Transduction R-HSA-177929: Signaling by EGFR R-HSA-449147: Signaling by Interleukins R-HSA-157118: Signaling by NOTCH R-HSA-186797: Signaling by PDGF R-HSA-1433557: Signaling by SCF-KIT R-HSA-983705: Signaling by the B Cell Receptor (BCR) R-HSA-166520: Signalling by NGF R-HSA-69541: Stabilization of p53 R-HSA-5628897: TP53 Regulates Metabolic Genes R-HSA-6803207: TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6791312: TP53 Regulates Transcription of Cell Cycle Genes R-HSA-5633008: TP53 Regulates Transcription of Cell Death Genes R-HSA-6796648: TP53 Regulates Transcription of DNA Repair Genes R-HSA-6803211: TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803204: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6804116: TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804114: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804115: TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6803205: TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-8852276: The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-69895: Transcriptional activation of cell cycle inhibitor p21 R-HSA-3700989: Transcriptional Regulation by TP53 R-HSA-69560: Transcriptional activation of p53 responsive genes R-HSA-5689880: Ub-specific processing proteases R-HSA-69563: p53-Dependent G1 DNA Damage Response R-HSA-69580: p53-Dependent G1/S DNA damage checkpoint |
Summary | |
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Symbol | TP53 |
Name | tumor protein p53 |
Aliases | p53; LFS1; Li-Fraumeni syndrome; BCC7; TRP53; antigen NY-CO-13; mutant tumor protein 53; p53 tumor suppresso ...... |
Chromosomal Location | 17p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TP53 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between TP53 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | TP53 |
Name | tumor protein p53 |
Aliases | p53; LFS1; Li-Fraumeni syndrome; BCC7; TRP53; antigen NY-CO-13; mutant tumor protein 53; p53 tumor suppresso ...... |
Chromosomal Location | 17p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TP53 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TP53 |
Name | tumor protein p53 |
Aliases | p53; LFS1; Li-Fraumeni syndrome; BCC7; TRP53; antigen NY-CO-13; mutant tumor protein 53; p53 tumor suppresso ...... |
Chromosomal Location | 17p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TP53 in various data sets.
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Points in the above scatter plot represent the mutation difference of TP53 in various data sets.
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Summary | |
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Symbol | TP53 |
Name | tumor protein p53 |
Aliases | p53; LFS1; Li-Fraumeni syndrome; BCC7; TRP53; antigen NY-CO-13; mutant tumor protein 53; p53 tumor suppresso ...... |
Chromosomal Location | 17p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TP53. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TP53 |
Name | tumor protein p53 |
Aliases | p53; LFS1; Li-Fraumeni syndrome; BCC7; TRP53; antigen NY-CO-13; mutant tumor protein 53; p53 tumor suppresso ...... |
Chromosomal Location | 17p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TP53. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TP53. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TP53 |
Name | tumor protein p53 |
Aliases | p53; LFS1; Li-Fraumeni syndrome; BCC7; TRP53; antigen NY-CO-13; mutant tumor protein 53; p53 tumor suppresso ...... |
Chromosomal Location | 17p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TP53. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TP53 |
Name | tumor protein p53 |
Aliases | p53; LFS1; Li-Fraumeni syndrome; BCC7; TRP53; antigen NY-CO-13; mutant tumor protein 53; p53 tumor suppresso ...... |
Chromosomal Location | 17p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TP53 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | TP53 |
Name | tumor protein p53 |
Aliases | p53; LFS1; Li-Fraumeni syndrome; BCC7; TRP53; antigen NY-CO-13; mutant tumor protein 53; p53 tumor suppresso ...... |
Chromosomal Location | 17p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TP53 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | TP53 |
Name | tumor protein p53 |
Aliases | p53; LFS1; Li-Fraumeni syndrome; BCC7; TRP53; antigen NY-CO-13; mutant tumor protein 53; p53 tumor suppresso ...... |
Chromosomal Location | 17p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TP53 collected from DrugBank database. |
Details on drugs targeting TP53.
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