Browse TP63

Summary
SymbolTP63
Nametumor protein p63
Aliases SHFM4; EEC3; p73L; OFC8; KET; p73H; p53CP; TP73L; TP53L; TP53CP; tumor protein p73-like; tumor protein p53-l ......
Chromosomal Location3q27-q29
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus
Domain PF00870 P53 DNA-binding domain
PF07710 P53 tetramerisation motif
PF07647 SAM domain (Sterile alpha motif)
Function

Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.

> Gene Ontology
 
Biological Process GO:0000075 cell cycle checkpoint
GO:0000077 DNA damage checkpoint
GO:0000082 G1/S transition of mitotic cell cycle
GO:0001302 replicative cell aging
GO:0001501 skeletal system development
GO:0001503 ossification
GO:0001649 osteoblast differentiation
GO:0001655 urogenital system development
GO:0001736 establishment of planar polarity
GO:0001738 morphogenesis of a polarized epithelium
GO:0001763 morphogenesis of a branching structure
GO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0001942 hair follicle development
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002064 epithelial cell development
GO:0002065 columnar/cuboidal epithelial cell differentiation
GO:0002067 glandular epithelial cell differentiation
GO:0003002 regionalization
GO:0006338 chromatin remodeling
GO:0006839 mitochondrial transport
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007006 mitochondrial membrane organization
GO:0007093 mitotic cell cycle checkpoint
GO:0007164 establishment of tissue polarity
GO:0007219 Notch signaling pathway
GO:0007283 spermatogenesis
GO:0007346 regulation of mitotic cell cycle
GO:0007389 pattern specification process
GO:0007498 mesoderm development
GO:0007499 ectoderm and mesoderm interaction
GO:0007548 sex differentiation
GO:0007568 aging
GO:0007569 cell aging
GO:0008544 epidermis development
GO:0008593 regulation of Notch signaling pathway
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008637 apoptotic mitochondrial changes
GO:0009314 response to radiation
GO:0009411 response to UV
GO:0009416 response to light stimulus
GO:0009913 epidermal cell differentiation
GO:0009954 proximal/distal pattern formation
GO:0010165 response to X-ray
GO:0010212 response to ionizing radiation
GO:0010259 multicellular organism aging
GO:0010332 response to gamma radiation
GO:0010463 mesenchymal cell proliferation
GO:0010464 regulation of mesenchymal cell proliferation
GO:0010481 epidermal cell division
GO:0010482 regulation of epidermal cell division
GO:0010821 regulation of mitochondrion organization
GO:0010822 positive regulation of mitochondrion organization
GO:0010837 regulation of keratinocyte proliferation
GO:0010838 positive regulation of keratinocyte proliferation
GO:0010948 negative regulation of cell cycle process
GO:0016331 morphogenesis of embryonic epithelium
GO:0022404 molting cycle process
GO:0022405 hair cycle process
GO:0022612 gland morphogenesis
GO:0030104 water homeostasis
GO:0030216 keratinocyte differentiation
GO:0030278 regulation of ossification
GO:0030326 embryonic limb morphogenesis
GO:0030330 DNA damage response, signal transduction by p53 class mediator
GO:0030540 female genitalia development
GO:0030850 prostate gland development
GO:0030856 regulation of epithelial cell differentiation
GO:0030857 negative regulation of epithelial cell differentiation
GO:0030859 polarized epithelial cell differentiation
GO:0031069 hair follicle morphogenesis
GO:0031570 DNA integrity checkpoint
GO:0031571 mitotic G1 DNA damage checkpoint
GO:0033561 regulation of water loss via skin
GO:0034644 cellular response to UV
GO:0035107 appendage morphogenesis
GO:0035108 limb morphogenesis
GO:0035112 genitalia morphogenesis
GO:0035113 embryonic appendage morphogenesis
GO:0035239 tube morphogenesis
GO:0035794 positive regulation of mitochondrial membrane permeability
GO:0035844 cloaca development
GO:0036342 post-anal tail morphogenesis
GO:0042303 molting cycle
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042476 odontogenesis
GO:0042633 hair cycle
GO:0042770 signal transduction in response to DNA damage
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042772 DNA damage response, signal transduction resulting in transcription
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043523 regulation of neuron apoptotic process
GO:0043588 skin development
GO:0043589 skin morphogenesis
GO:0043616 keratinocyte proliferation
GO:0044346 fibroblast apoptotic process
GO:0044770 cell cycle phase transition
GO:0044772 mitotic cell cycle phase transition
GO:0044773 mitotic DNA damage checkpoint
GO:0044774 mitotic DNA integrity checkpoint
GO:0044783 G1 DNA damage checkpoint
GO:0044819 mitotic G1/S transition checkpoint
GO:0044843 cell cycle G1/S phase transition
GO:0045604 regulation of epidermal cell differentiation
GO:0045605 negative regulation of epidermal cell differentiation
GO:0045616 regulation of keratinocyte differentiation
GO:0045617 negative regulation of keratinocyte differentiation
GO:0045667 regulation of osteoblast differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045682 regulation of epidermis development
GO:0045683 negative regulation of epidermis development
GO:0045747 positive regulation of Notch signaling pathway
GO:0045778 positive regulation of ossification
GO:0045786 negative regulation of cell cycle
GO:0045930 negative regulation of mitotic cell cycle
GO:0046660 female sex differentiation
GO:0046902 regulation of mitochondrial membrane permeability
GO:0048232 male gamete generation
GO:0048483 autonomic nervous system development
GO:0048485 sympathetic nervous system development
GO:0048546 digestive tract morphogenesis
GO:0048565 digestive tract development
GO:0048608 reproductive structure development
GO:0048645 animal organ formation
GO:0048730 epidermis morphogenesis
GO:0048732 gland development
GO:0048736 appendage development
GO:0048745 smooth muscle tissue development
GO:0048806 genitalia development
GO:0048807 female genitalia morphogenesis
GO:0048863 stem cell differentiation
GO:0048871 multicellular organismal homeostasis
GO:0050673 epithelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050878 regulation of body fluid levels
GO:0050891 multicellular organismal water homeostasis
GO:0051204 protein insertion into mitochondrial membrane
GO:0051205 protein insertion into membrane
GO:0051259 protein oligomerization
GO:0051260 protein homooligomerization
GO:0051262 protein tetramerization
GO:0051289 protein homotetramerization
GO:0051302 regulation of cell division
GO:0051402 neuron apoptotic process
GO:0052547 regulation of peptidase activity
GO:0052548 regulation of endopeptidase activity
GO:0055123 digestive system development
GO:0060157 urinary bladder development
GO:0060173 limb development
GO:0060197 cloacal septation
GO:0060512 prostate gland morphogenesis
GO:0060513 prostatic bud formation
GO:0060525 prostate glandular acinus development
GO:0060529 squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
GO:0060537 muscle tissue development
GO:0060571 morphogenesis of an epithelial fold
GO:0060572 morphogenesis of an epithelial bud
GO:0060601 lateral sprouting from an epithelium
GO:0060740 prostate gland epithelium morphogenesis
GO:0060742 epithelial cell differentiation involved in prostate gland development
GO:0061138 morphogenesis of a branching epithelium
GO:0061436 establishment of skin barrier
GO:0061458 reproductive system development
GO:0070585 protein localization to mitochondrion
GO:0070997 neuron death
GO:0071214 cellular response to abiotic stimulus
GO:0071478 cellular response to radiation
GO:0071482 cellular response to light stimulus
GO:0072001 renal system development
GO:0072331 signal transduction by p53 class mediator
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
GO:0072655 establishment of protein localization to mitochondrion
GO:0072657 protein localization to membrane
GO:0090150 establishment of protein localization to membrane
GO:0090559 regulation of membrane permeability
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097345 mitochondrial outer membrane permeabilization
GO:0098773 skin epidermis development
GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1901214 regulation of neuron death
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1901987 regulation of cell cycle phase transition
GO:1901988 negative regulation of cell cycle phase transition
GO:1901990 regulation of mitotic cell cycle phase transition
GO:1901991 negative regulation of mitotic cell cycle phase transition
GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death
GO:1902806 regulation of cell cycle G1/S phase transition
GO:1902807 negative regulation of cell cycle G1/S phase transition
GO:1903747 regulation of establishment of protein localization to mitochondrion
GO:1903749 positive regulation of establishment of protein localization to mitochondrion
GO:1903829 positive regulation of cellular protein localization
GO:1904951 positive regulation of establishment of protein localization
GO:2000045 regulation of G1/S transition of mitotic cell cycle
GO:2000116 regulation of cysteine-type endopeptidase activity
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
GO:2000269 regulation of fibroblast apoptotic process
GO:2000271 positive regulation of fibroblast apoptotic process
GO:2000380 regulation of mesoderm development
GO:2000381 negative regulation of mesoderm development
GO:2001233 regulation of apoptotic signaling pathway
GO:2001235 positive regulation of apoptotic signaling pathway
Molecular Function GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0002039 p53 binding
GO:0003682 chromatin binding
GO:0003684 damaged DNA binding
GO:0050699 WW domain binding
Cellular Component GO:0000785 chromatin
GO:0000790 nuclear chromatin
GO:0005667 transcription factor complex
GO:0005791 rough endoplasmic reticulum
GO:0030425 dendrite
GO:0044454 nuclear chromosome part
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-114452: Activation of BH3-only proteins
R-HSA-139915: Activation of PUMA and translocation to mitochondria
R-HSA-109581: Apoptosis
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-109606: Intrinsic Pathway for Apoptosis
R-HSA-5357801: Programmed Cell Death
R-HSA-5633007: Regulation of TP53 Activity
R-HSA-6804759: Regulation of TP53 Activity through Association with Co-factors
R-HSA-5628897: TP53 Regulates Metabolic Genes
R-HSA-6803207: TP53 Regulates Transcription of Caspase Activators and Caspases
R-HSA-5633008: TP53 Regulates Transcription of Cell Death Genes
R-HSA-6803211: TP53 Regulates Transcription of Death Receptors and Ligands
R-HSA-6803204: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
R-HSA-6803205: TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
R-HSA-3700989: Transcriptional Regulation by TP53
Summary
SymbolTP63
Nametumor protein p63
Aliases SHFM4; EEC3; p73L; OFC8; KET; p73H; p53CP; TP73L; TP53L; TP53CP; tumor protein p73-like; tumor protein p53-l ......
Chromosomal Location3q27-q29
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between TP63 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between TP63 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
29866045Squamous Cell Lung CarcinomaInhibit immunityWe found that the TP63/SOX2/DMRT3 module was specific to LUSC, corresponding to squamous epithelial differentiation and/or survival.
Summary
SymbolTP63
Nametumor protein p63
Aliases SHFM4; EEC3; p73L; OFC8; KET; p73H; p53CP; TP73L; TP53L; TP53CP; tumor protein p73-like; tumor protein p53-l ......
Chromosomal Location3q27-q29
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of TP63 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolTP63
Nametumor protein p63
Aliases SHFM4; EEC3; p73L; OFC8; KET; p73H; p53CP; TP73L; TP53L; TP53CP; tumor protein p73-like; tumor protein p53-l ......
Chromosomal Location3q27-q29
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of TP63 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.4590.429
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.0370.968
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.8350.297
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.6610.295
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.5210.818
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.8490.739
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0450.951
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0560.958
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.0540.961
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.0150.971
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.1760.758
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.7340.0243
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of TP63 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277314.812.32.50.744
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275914.813.61.21
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211714.317.6-3.31
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131123.127.3-4.21
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.16.24.91
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 592011.18.91
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 382718.43.714.70.126
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221313.67.75.91
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1614250250.103
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolTP63
Nametumor protein p63
Aliases SHFM4; EEC3; p73L; OFC8; KET; p73H; p53CP; TP73L; TP53L; TP53CP; tumor protein p73-like; tumor protein p53-l ......
Chromosomal Location3q27-q29
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TP63. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolTP63
Nametumor protein p63
Aliases SHFM4; EEC3; p73L; OFC8; KET; p73H; p53CP; TP73L; TP53L; TP53CP; tumor protein p73-like; tumor protein p53-l ......
Chromosomal Location3q27-q29
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TP63. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TP63.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolTP63
Nametumor protein p63
Aliases SHFM4; EEC3; p73L; OFC8; KET; p73H; p53CP; TP73L; TP53L; TP53CP; tumor protein p73-like; tumor protein p53-l ......
Chromosomal Location3q27-q29
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TP63. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolTP63
Nametumor protein p63
Aliases SHFM4; EEC3; p73L; OFC8; KET; p73H; p53CP; TP73L; TP53L; TP53CP; tumor protein p73-like; tumor protein p53-l ......
Chromosomal Location3q27-q29
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of TP63 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolTP63
Nametumor protein p63
Aliases SHFM4; EEC3; p73L; OFC8; KET; p73H; p53CP; TP73L; TP53L; TP53CP; tumor protein p73-like; tumor protein p53-l ......
Chromosomal Location3q27-q29
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between TP63 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolTP63
Nametumor protein p63
Aliases SHFM4; EEC3; p73L; OFC8; KET; p73H; p53CP; TP73L; TP53L; TP53CP; tumor protein p73-like; tumor protein p53-l ......
Chromosomal Location3q27-q29
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting TP63 collected from DrugBank database.
> Drugs from DrugBank database
 

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