Summary | |
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Symbol | TPBG |
Name | trophoblast glycoprotein |
Aliases | 5T4-AG; 5T4; 5T4AG; M6P1; WAIF1; 5T4 oncofetal antigen; 5T4 oncofetal trophoblast glycoprotein; 5T4 oncotrop ...... |
Chromosomal Location | 6q14-q15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type I membrane protein |
Domain |
PF13855 Leucine rich repeat PF01463 Leucine rich repeat C-terminal domain PF01462 Leucine rich repeat N-terminal domain |
Function |
May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. |
Biological Process |
GO:0007416 synapse assembly GO:0044089 positive regulation of cellular component biogenesis GO:0050803 regulation of synapse structure or activity GO:0050807 regulation of synapse organization GO:0050808 synapse organization GO:0051962 positive regulation of nervous system development GO:0051963 regulation of synapse assembly GO:0051965 positive regulation of synapse assembly |
Molecular Function | - |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | TPBG |
Name | trophoblast glycoprotein |
Aliases | 5T4-AG; 5T4; 5T4AG; M6P1; WAIF1; 5T4 oncofetal antigen; 5T4 oncofetal trophoblast glycoprotein; 5T4 oncotrop ...... |
Chromosomal Location | 6q14-q15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TPBG and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between TPBG and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | TPBG |
Name | trophoblast glycoprotein |
Aliases | 5T4-AG; 5T4; 5T4AG; M6P1; WAIF1; 5T4 oncofetal antigen; 5T4 oncofetal trophoblast glycoprotein; 5T4 oncotrop ...... |
Chromosomal Location | 6q14-q15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TPBG in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TPBG |
Name | trophoblast glycoprotein |
Aliases | 5T4-AG; 5T4; 5T4AG; M6P1; WAIF1; 5T4 oncofetal antigen; 5T4 oncofetal trophoblast glycoprotein; 5T4 oncotrop ...... |
Chromosomal Location | 6q14-q15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TPBG in various data sets.
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Points in the above scatter plot represent the mutation difference of TPBG in various data sets.
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Summary | |
---|---|
Symbol | TPBG |
Name | trophoblast glycoprotein |
Aliases | 5T4-AG; 5T4; 5T4AG; M6P1; WAIF1; 5T4 oncofetal antigen; 5T4 oncofetal trophoblast glycoprotein; 5T4 oncotrop ...... |
Chromosomal Location | 6q14-q15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TPBG. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TPBG |
Name | trophoblast glycoprotein |
Aliases | 5T4-AG; 5T4; 5T4AG; M6P1; WAIF1; 5T4 oncofetal antigen; 5T4 oncofetal trophoblast glycoprotein; 5T4 oncotrop ...... |
Chromosomal Location | 6q14-q15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TPBG. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TPBG. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TPBG |
Name | trophoblast glycoprotein |
Aliases | 5T4-AG; 5T4; 5T4AG; M6P1; WAIF1; 5T4 oncofetal antigen; 5T4 oncofetal trophoblast glycoprotein; 5T4 oncotrop ...... |
Chromosomal Location | 6q14-q15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TPBG. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | TPBG |
Name | trophoblast glycoprotein |
Aliases | 5T4-AG; 5T4; 5T4AG; M6P1; WAIF1; 5T4 oncofetal antigen; 5T4 oncofetal trophoblast glycoprotein; 5T4 oncotrop ...... |
Chromosomal Location | 6q14-q15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TPBG expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TPBG |
Name | trophoblast glycoprotein |
Aliases | 5T4-AG; 5T4; 5T4AG; M6P1; WAIF1; 5T4 oncofetal antigen; 5T4 oncofetal trophoblast glycoprotein; 5T4 oncotrop ...... |
Chromosomal Location | 6q14-q15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TPBG and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TPBG |
Name | trophoblast glycoprotein |
Aliases | 5T4-AG; 5T4; 5T4AG; M6P1; WAIF1; 5T4 oncofetal antigen; 5T4 oncofetal trophoblast glycoprotein; 5T4 oncotrop ...... |
Chromosomal Location | 6q14-q15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TPBG collected from DrugBank database. |
There is no record. |